Cross-Protection of an Inactivated and a Live-Attenuated Lumpy Skin Disease Virus Vaccine against Sheeppox Virus Infections in Sheep
Sheeppox virus (SPPV) (genus Capripoxvirus, family Poxviridae) infections are a highly virulent and contagious disease of sheep with a high morbidity and mortality, especially in naïve populations and young animals. For the control of SPPV, homologous and heterologous live-attenuated vaccines are co...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-03-01
|
| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/11/4/763 |
| _version_ | 1797603292693397504 |
|---|---|
| author | Janika Wolff Martin Beer Bernd Hoffmann |
| author_facet | Janika Wolff Martin Beer Bernd Hoffmann |
| author_sort | Janika Wolff |
| collection | DOAJ |
| description | Sheeppox virus (SPPV) (genus Capripoxvirus, family Poxviridae) infections are a highly virulent and contagious disease of sheep with a high morbidity and mortality, especially in naïve populations and young animals. For the control of SPPV, homologous and heterologous live-attenuated vaccines are commercially available. In our study, we compared a commercially available live-attenuated lumpy skin disease virus (LSDV) vaccine strain (Lumpyvax) with our recently developed inactivated LSDV vaccine candidate regarding their protective efficacy against SPPV in sheep. Both vaccines were proven to be safe in sheep, and neither clinical signs nor viremia could be detected after vaccination and challenge infection. However, the local replication of the challenge virus in the nasal mucosa of previously vaccinated animals was observed. Because of the advantages of an inactivated vaccine and its heterologous protection efficacy against SPPV in sheep, our inactivated LSDV vaccine candidate is a promising additional tool for the prevention and control of SPPV outbreaks in the future. |
| first_indexed | 2024-03-11T04:27:14Z |
| format | Article |
| id | doaj.art-7f4a748900d047a4919727fb6f53e987 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-11T04:27:14Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-7f4a748900d047a4919727fb6f53e9872023-11-17T21:41:23ZengMDPI AGVaccines2076-393X2023-03-0111476310.3390/vaccines11040763Cross-Protection of an Inactivated and a Live-Attenuated Lumpy Skin Disease Virus Vaccine against Sheeppox Virus Infections in SheepJanika Wolff0Martin Beer1Bernd Hoffmann2Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Südufer 10, D-17493 Greifswald-Insel Riems, GermanyInstitute of Diagnostic Virology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Südufer 10, D-17493 Greifswald-Insel Riems, GermanyInstitute of Diagnostic Virology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Südufer 10, D-17493 Greifswald-Insel Riems, GermanySheeppox virus (SPPV) (genus Capripoxvirus, family Poxviridae) infections are a highly virulent and contagious disease of sheep with a high morbidity and mortality, especially in naïve populations and young animals. For the control of SPPV, homologous and heterologous live-attenuated vaccines are commercially available. In our study, we compared a commercially available live-attenuated lumpy skin disease virus (LSDV) vaccine strain (Lumpyvax) with our recently developed inactivated LSDV vaccine candidate regarding their protective efficacy against SPPV in sheep. Both vaccines were proven to be safe in sheep, and neither clinical signs nor viremia could be detected after vaccination and challenge infection. However, the local replication of the challenge virus in the nasal mucosa of previously vaccinated animals was observed. Because of the advantages of an inactivated vaccine and its heterologous protection efficacy against SPPV in sheep, our inactivated LSDV vaccine candidate is a promising additional tool for the prevention and control of SPPV outbreaks in the future.https://www.mdpi.com/2076-393X/11/4/763capripox virussheeppox virusSPPVlumpy skin disease virusLSDVinactivated vaccine |
| spellingShingle | Janika Wolff Martin Beer Bernd Hoffmann Cross-Protection of an Inactivated and a Live-Attenuated Lumpy Skin Disease Virus Vaccine against Sheeppox Virus Infections in Sheep Vaccines capripox virus sheeppox virus SPPV lumpy skin disease virus LSDV inactivated vaccine |
| title | Cross-Protection of an Inactivated and a Live-Attenuated Lumpy Skin Disease Virus Vaccine against Sheeppox Virus Infections in Sheep |
| title_full | Cross-Protection of an Inactivated and a Live-Attenuated Lumpy Skin Disease Virus Vaccine against Sheeppox Virus Infections in Sheep |
| title_fullStr | Cross-Protection of an Inactivated and a Live-Attenuated Lumpy Skin Disease Virus Vaccine against Sheeppox Virus Infections in Sheep |
| title_full_unstemmed | Cross-Protection of an Inactivated and a Live-Attenuated Lumpy Skin Disease Virus Vaccine against Sheeppox Virus Infections in Sheep |
| title_short | Cross-Protection of an Inactivated and a Live-Attenuated Lumpy Skin Disease Virus Vaccine against Sheeppox Virus Infections in Sheep |
| title_sort | cross protection of an inactivated and a live attenuated lumpy skin disease virus vaccine against sheeppox virus infections in sheep |
| topic | capripox virus sheeppox virus SPPV lumpy skin disease virus LSDV inactivated vaccine |
| url | https://www.mdpi.com/2076-393X/11/4/763 |
| work_keys_str_mv | AT janikawolff crossprotectionofaninactivatedandaliveattenuatedlumpyskindiseasevirusvaccineagainstsheeppoxvirusinfectionsinsheep AT martinbeer crossprotectionofaninactivatedandaliveattenuatedlumpyskindiseasevirusvaccineagainstsheeppoxvirusinfectionsinsheep AT berndhoffmann crossprotectionofaninactivatedandaliveattenuatedlumpyskindiseasevirusvaccineagainstsheeppoxvirusinfectionsinsheep |