Clinical Aspects of Microsatellite Instability Testing in Colorectal Cancer

Clinical Aspects of Microsatellite Instability Testing in Colorectal Cancer

Microsatellite instability (MSI) is a molecular hallmark for some colorectal cancers (CRCs) in which short tandem repeats are prone to mutations along with DNA sequences. It is due to DNA-mismatch-repair system deficiency because of a germline/somatic mutation in mismatch-repair (MMR) genes. The ger...

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Bibliographic Details
Main Authors: Mehrdad Zeinalian, Morteza Hashemzadeh-Chaleshtori, Rasoul Salehi, Mohammad Hassan Emami
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:Advanced Biomedical Research
Subjects:
Colorectal cancer
Lynch syndrome
microsatellite instability
microsatellite instability testing
mismatch-repair
Online Access:http://www.advbiores.net/article.asp?issn=2277-9175;year=2018;volume=7;issue=1;spage=28;epage=28;aulast=Zeinalian

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