Long-term Survival After Diverse Therapeutic Modalities in Malignant Phyllodes Tumors of the Breast
Background and Objects: Malignant phyllodes tumor of the breast (MPTB) is a rare tumor for which surgery or surgery combined with radiotherapy (RT) is the primary treatment method. However, recently, the therapeutic effect of RT on MPTB has been controversial. We aimed to explore the role of RT, che...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-08-01
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| Series: | Technology in Cancer Research & Treatment |
| Online Access: | https://doi.org/10.1177/15330338221121086 |
| _version_ | 1797689782013263872 |
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| author | Hongyi Zhang MD Shasha Tang MD Ewelina Biskup MD Yi Zhang MD Liyun Yong MD Lijun Chen MD Fengfeng Cai MD |
| author_facet | Hongyi Zhang MD Shasha Tang MD Ewelina Biskup MD Yi Zhang MD Liyun Yong MD Lijun Chen MD Fengfeng Cai MD |
| author_sort | Hongyi Zhang MD |
| collection | DOAJ |
| description | Background and Objects: Malignant phyllodes tumor of the breast (MPTB) is a rare tumor for which surgery or surgery combined with radiotherapy (RT) is the primary treatment method. However, recently, the therapeutic effect of RT on MPTB has been controversial. We aimed to explore the role of RT, chemotherapy (CT), and surgical modalities in patients with MPTB. Methods: The Surveillance, Epidemiology, and End Results (SEER) database was used to select patients with MPTB who met the criteria between 2010 and 2018. Kaplan–Meier curves and Cox proportional risk regression models were used to analyze the effects of RT on MPTB patients. Based on this, we compared the effects of breast-conserving surgery (BSC) and mastectomy on the postoperative survival of MPTB. Results: A total of 298 patients with MPTB were included in this study. RT was received by 22.1% (n = 66) of the patients while 77.9% (n = 232) did not receive RT. CT was received by 4.7% (n = 14) patients while 95.3% (n = 284) did not receive CT. According to Kaplan–Meier curves, RT and CT combined resulted in a decrease in breast cancer-specific survival (BCSS) and overall survival (OS) compared to patients who did not receive RT. Mastectomy improved the OS and BCSS of the patients more than BCS). The findings of univariate and multivariate Cox regression analyses suggested that “distant metastasis”, “tumor grade” and “number of positive lymph node biopsies” affected OS of breast cancer, while “distant metastasis”, “tumor grade”, “surgery combined with radiotherapy/surgery”, and “radiotherapy/chemotherapy or not”, had a significant effect on BCSS. Conclusion: RT and CT did not significantly improve the long-term survival of MPTB patients. Mastectomy improved OS and BCSS of the patient more than BCS. RT in an early stage improved early prognosis moderately in MPTB patients with tumor diameter less than 50 mm. |
| first_indexed | 2024-03-12T01:51:20Z |
| format | Article |
| id | doaj.art-7f4c17951a7143d48ce1de2524553042 |
| institution | Directory Open Access Journal |
| issn | 1533-0338 |
| language | English |
| last_indexed | 2024-03-12T01:51:20Z |
| publishDate | 2022-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Technology in Cancer Research & Treatment |
| spelling | doaj.art-7f4c17951a7143d48ce1de25245530422023-09-08T13:34:46ZengSAGE PublishingTechnology in Cancer Research & Treatment1533-03382022-08-012110.1177/15330338221121086Long-term Survival After Diverse Therapeutic Modalities in Malignant Phyllodes Tumors of the BreastHongyi Zhang MD0Shasha Tang MD1Ewelina Biskup MD2Yi Zhang MD3Liyun Yong MD4Lijun Chen MD5Fengfeng Cai MD6 Department of Breast Surgery, School of Medicine, Yangpu Hospital, , Shanghai, China Department of Breast Surgery, School of Medicine, Yangpu Hospital, , Shanghai, China , Shanghai, PR China Department of Breast Surgery, School of Medicine, Yangpu Hospital, , Shanghai, China Department of Breast Surgery, School of Medicine, Yangpu Hospital, , Shanghai, China Department of Oncology, , Fudan University, Shanghai, China Department of Breast Surgery, School of Medicine, Yangpu Hospital, , Shanghai, ChinaBackground and Objects: Malignant phyllodes tumor of the breast (MPTB) is a rare tumor for which surgery or surgery combined with radiotherapy (RT) is the primary treatment method. However, recently, the therapeutic effect of RT on MPTB has been controversial. We aimed to explore the role of RT, chemotherapy (CT), and surgical modalities in patients with MPTB. Methods: The Surveillance, Epidemiology, and End Results (SEER) database was used to select patients with MPTB who met the criteria between 2010 and 2018. Kaplan–Meier curves and Cox proportional risk regression models were used to analyze the effects of RT on MPTB patients. Based on this, we compared the effects of breast-conserving surgery (BSC) and mastectomy on the postoperative survival of MPTB. Results: A total of 298 patients with MPTB were included in this study. RT was received by 22.1% (n = 66) of the patients while 77.9% (n = 232) did not receive RT. CT was received by 4.7% (n = 14) patients while 95.3% (n = 284) did not receive CT. According to Kaplan–Meier curves, RT and CT combined resulted in a decrease in breast cancer-specific survival (BCSS) and overall survival (OS) compared to patients who did not receive RT. Mastectomy improved the OS and BCSS of the patients more than BCS). The findings of univariate and multivariate Cox regression analyses suggested that “distant metastasis”, “tumor grade” and “number of positive lymph node biopsies” affected OS of breast cancer, while “distant metastasis”, “tumor grade”, “surgery combined with radiotherapy/surgery”, and “radiotherapy/chemotherapy or not”, had a significant effect on BCSS. Conclusion: RT and CT did not significantly improve the long-term survival of MPTB patients. Mastectomy improved OS and BCSS of the patient more than BCS. RT in an early stage improved early prognosis moderately in MPTB patients with tumor diameter less than 50 mm.https://doi.org/10.1177/15330338221121086 |
| spellingShingle | Hongyi Zhang MD Shasha Tang MD Ewelina Biskup MD Yi Zhang MD Liyun Yong MD Lijun Chen MD Fengfeng Cai MD Long-term Survival After Diverse Therapeutic Modalities in Malignant Phyllodes Tumors of the Breast Technology in Cancer Research & Treatment |
| title | Long-term Survival After Diverse Therapeutic Modalities in Malignant Phyllodes Tumors of the Breast |
| title_full | Long-term Survival After Diverse Therapeutic Modalities in Malignant Phyllodes Tumors of the Breast |
| title_fullStr | Long-term Survival After Diverse Therapeutic Modalities in Malignant Phyllodes Tumors of the Breast |
| title_full_unstemmed | Long-term Survival After Diverse Therapeutic Modalities in Malignant Phyllodes Tumors of the Breast |
| title_short | Long-term Survival After Diverse Therapeutic Modalities in Malignant Phyllodes Tumors of the Breast |
| title_sort | long term survival after diverse therapeutic modalities in malignant phyllodes tumors of the breast |
| url | https://doi.org/10.1177/15330338221121086 |
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