A global repository of novel antimicrobial emergence events [version 2; peer review: 1 approved, 2 approved with reservations]
Despite considerable global surveillance of antimicrobial resistance (AMR), data on the global emergence of new resistance genotypes in bacteria has not been systematically compiled. We conducted a study of English-language scientific literature (2006-2017) and ProMED-mail disease surveillance repor...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2021-06-01
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| Series: | F1000Research |
| Online Access: | https://f1000research.com/articles/9-1320/v2 |
| _version_ | 1818844078130855936 |
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| author | Emma Mendelsohn Noam Ross Allison M. White Karissa Whiting Cale Basaraba Brooke Watson Madubuonwu Erica Johnson Mushtaq Dualeh Zach Matson Sonia Dattaray Nchedochukwu Ezeokoli Melanie Kirshenbaum Lieberman Jacob Kotcher Samantha Maher Carlos Zambrana-Torrelio Peter Daszak |
| author_facet | Emma Mendelsohn Noam Ross Allison M. White Karissa Whiting Cale Basaraba Brooke Watson Madubuonwu Erica Johnson Mushtaq Dualeh Zach Matson Sonia Dattaray Nchedochukwu Ezeokoli Melanie Kirshenbaum Lieberman Jacob Kotcher Samantha Maher Carlos Zambrana-Torrelio Peter Daszak |
| author_sort | Emma Mendelsohn |
| collection | DOAJ |
| description | Despite considerable global surveillance of antimicrobial resistance (AMR), data on the global emergence of new resistance genotypes in bacteria has not been systematically compiled. We conducted a study of English-language scientific literature (2006-2017) and ProMED-mail disease surveillance reports (1994-2017) to identify global events of novel AMR emergence (first clinical reports of unique drug-bacteria resistance combinations). We screened 24,966 abstracts and reports, ultimately identifying 1,757 novel AMR emergence events from 268 peer-reviewed studies and 26 disease surveillance reports (294 total). Events were reported in 66 countries, with most events in the United States (152), China (128), and India (127). The most common bacteria demonstrating new resistance were Klebsiella pneumoniae (344) and Escherichia coli (218). Resistance was most common against antibiotic drugs imipenem (89 events), ciprofloxacin (84) and ceftazidime (83). We provide an open-access database of emergence events with standardized fields for bacterial species, drugs, location, and date. We discuss the impact of reporting and surveillance bias on database coverage, and we suggest guidelines for data analysis. This database may be broadly useful for understanding rates and patterns of AMR evolution, identifying global drivers and correlates, and targeting surveillance and interventions. |
| first_indexed | 2024-12-19T05:08:02Z |
| format | Article |
| id | doaj.art-7f4c3ff909c9422cbd06ea3491475b4f |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-19T05:08:02Z |
| publishDate | 2021-06-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-7f4c3ff909c9422cbd06ea3491475b4f2022-12-21T20:34:53ZengF1000 Research LtdF1000Research2046-14022021-06-01910.12688/f1000research.26870.257747A global repository of novel antimicrobial emergence events [version 2; peer review: 1 approved, 2 approved with reservations]Emma Mendelsohn0Noam Ross1Allison M. White2Karissa Whiting3Cale Basaraba4Brooke Watson Madubuonwu5Erica Johnson6Mushtaq Dualeh7Zach Matson8Sonia Dattaray9Nchedochukwu Ezeokoli10Melanie Kirshenbaum Lieberman11Jacob Kotcher12Samantha Maher13Carlos Zambrana-Torrelio14Peter Daszak15EcoHealth Alliance, New York, NY, 10018, USAEcoHealth Alliance, New York, NY, 10018, USAEcoHealth Alliance, New York, NY, 10018, USAEcoHealth Alliance, New York, NY, 10018, USAEcoHealth Alliance, New York, NY, 10018, USAEcoHealth Alliance, New York, NY, 10018, USAEcoHealth Alliance, New York, NY, 10018, USAEcoHealth Alliance, New York, NY, 10018, USAEcoHealth Alliance, New York, NY, 10018, USAEcoHealth Alliance, New York, NY, 10018, USAEcoHealth Alliance, New York, NY, 10018, USAEcoHealth Alliance, New York, NY, 10018, USAEcoHealth Alliance, New York, NY, 10018, USAEcoHealth Alliance, New York, NY, 10018, USAEcoHealth Alliance, New York, NY, 10018, USAEcoHealth Alliance, New York, NY, 10018, USADespite considerable global surveillance of antimicrobial resistance (AMR), data on the global emergence of new resistance genotypes in bacteria has not been systematically compiled. We conducted a study of English-language scientific literature (2006-2017) and ProMED-mail disease surveillance reports (1994-2017) to identify global events of novel AMR emergence (first clinical reports of unique drug-bacteria resistance combinations). We screened 24,966 abstracts and reports, ultimately identifying 1,757 novel AMR emergence events from 268 peer-reviewed studies and 26 disease surveillance reports (294 total). Events were reported in 66 countries, with most events in the United States (152), China (128), and India (127). The most common bacteria demonstrating new resistance were Klebsiella pneumoniae (344) and Escherichia coli (218). Resistance was most common against antibiotic drugs imipenem (89 events), ciprofloxacin (84) and ceftazidime (83). We provide an open-access database of emergence events with standardized fields for bacterial species, drugs, location, and date. We discuss the impact of reporting and surveillance bias on database coverage, and we suggest guidelines for data analysis. This database may be broadly useful for understanding rates and patterns of AMR evolution, identifying global drivers and correlates, and targeting surveillance and interventions.https://f1000research.com/articles/9-1320/v2 |
| spellingShingle | Emma Mendelsohn Noam Ross Allison M. White Karissa Whiting Cale Basaraba Brooke Watson Madubuonwu Erica Johnson Mushtaq Dualeh Zach Matson Sonia Dattaray Nchedochukwu Ezeokoli Melanie Kirshenbaum Lieberman Jacob Kotcher Samantha Maher Carlos Zambrana-Torrelio Peter Daszak A global repository of novel antimicrobial emergence events [version 2; peer review: 1 approved, 2 approved with reservations] F1000Research |
| title | A global repository of novel antimicrobial emergence events [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_full | A global repository of novel antimicrobial emergence events [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_fullStr | A global repository of novel antimicrobial emergence events [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_full_unstemmed | A global repository of novel antimicrobial emergence events [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_short | A global repository of novel antimicrobial emergence events [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_sort | global repository of novel antimicrobial emergence events version 2 peer review 1 approved 2 approved with reservations |
| url | https://f1000research.com/articles/9-1320/v2 |
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