Metabolomic and lipidomic studies on the intervention of taurochenodeoxycholic acid in mice with hyperlipidemia
Bile acids are the main component of animal bile and are directly involved in the metabolic process of lipids in vivo. Taurochenodeoxycholic acid (TCDCA) is the primary biologically active substance in bile acids and has biological functions such as antioxidant, antipyretic, anti-inflammatory, and a...
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1255931/full |
| _version_ | 1797614216623947776 |
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| author | Na Cui Wensen Zhang Fazhi Su Zhihong Zhang Biao Li Donghui Peng Yanping Sun Yuanning Zeng Bingyou Yang Haixue Kuang Qiuhong Wang |
| author_facet | Na Cui Wensen Zhang Fazhi Su Zhihong Zhang Biao Li Donghui Peng Yanping Sun Yuanning Zeng Bingyou Yang Haixue Kuang Qiuhong Wang |
| author_sort | Na Cui |
| collection | DOAJ |
| description | Bile acids are the main component of animal bile and are directly involved in the metabolic process of lipids in vivo. Taurochenodeoxycholic acid (TCDCA) is the primary biologically active substance in bile acids and has biological functions such as antioxidant, antipyretic, anti-inflammatory, and analgesic activities and improves immunity. In the present study, we assessed the impact of TCDCA on hyperlipidemia development in mouse models. Mice were fed a high-fat diet (HFD) to induce hyperlipidemia and orally administered different doses of TCDCA orally for 30 days. Then, indicators such as triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in mice were detected. Using HE and ORO staining techniques, the morphology of the mice’s liver tissue was detected. Based on metabolomic and lipidomic analyses, we determined the mechanism of TCDCA in treating hyperlipidemia. The results showed that TCDCA had a significant ameliorating effect on dietary hyperlipidemia. In addition, it exerted therapeutic effects through glycerophospholipid metabolism. |
| first_indexed | 2024-03-11T07:05:41Z |
| format | Article |
| id | doaj.art-7f4c8b98cf9b4a64baa9ea399482c5cb |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-11T07:05:41Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-7f4c8b98cf9b4a64baa9ea399482c5cb2023-11-17T08:56:04ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-11-011410.3389/fphar.2023.12559311255931Metabolomic and lipidomic studies on the intervention of taurochenodeoxycholic acid in mice with hyperlipidemiaNa Cui0Wensen Zhang1Fazhi Su2Zhihong Zhang3Biao Li4Donghui Peng5Yanping Sun6Yuanning Zeng7Bingyou Yang8Haixue Kuang9Qiuhong Wang10Key Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin, ChinaKey Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin, ChinaKey Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin, ChinaKey Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin, ChinaKey Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin, ChinaKey Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin, ChinaKey Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin, ChinaSchool of Chinese Materia Medica, Guangdong Engineering Technology Research Center for Standardized Processing of Chinese Materia Medica Guangdong Pharmaceutical University, Guangdong, ChinaKey Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin, ChinaKey Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin, ChinaSchool of Chinese Materia Medica, Guangdong Engineering Technology Research Center for Standardized Processing of Chinese Materia Medica Guangdong Pharmaceutical University, Guangdong, ChinaBile acids are the main component of animal bile and are directly involved in the metabolic process of lipids in vivo. Taurochenodeoxycholic acid (TCDCA) is the primary biologically active substance in bile acids and has biological functions such as antioxidant, antipyretic, anti-inflammatory, and analgesic activities and improves immunity. In the present study, we assessed the impact of TCDCA on hyperlipidemia development in mouse models. Mice were fed a high-fat diet (HFD) to induce hyperlipidemia and orally administered different doses of TCDCA orally for 30 days. Then, indicators such as triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in mice were detected. Using HE and ORO staining techniques, the morphology of the mice’s liver tissue was detected. Based on metabolomic and lipidomic analyses, we determined the mechanism of TCDCA in treating hyperlipidemia. The results showed that TCDCA had a significant ameliorating effect on dietary hyperlipidemia. In addition, it exerted therapeutic effects through glycerophospholipid metabolism.https://www.frontiersin.org/articles/10.3389/fphar.2023.1255931/fulltaurochenodeoxycholic acidhyperlipidemiametabolomicslipidomicsglycerophospholipid metabolism |
| spellingShingle | Na Cui Wensen Zhang Fazhi Su Zhihong Zhang Biao Li Donghui Peng Yanping Sun Yuanning Zeng Bingyou Yang Haixue Kuang Qiuhong Wang Metabolomic and lipidomic studies on the intervention of taurochenodeoxycholic acid in mice with hyperlipidemia Frontiers in Pharmacology taurochenodeoxycholic acid hyperlipidemia metabolomics lipidomics glycerophospholipid metabolism |
| title | Metabolomic and lipidomic studies on the intervention of taurochenodeoxycholic acid in mice with hyperlipidemia |
| title_full | Metabolomic and lipidomic studies on the intervention of taurochenodeoxycholic acid in mice with hyperlipidemia |
| title_fullStr | Metabolomic and lipidomic studies on the intervention of taurochenodeoxycholic acid in mice with hyperlipidemia |
| title_full_unstemmed | Metabolomic and lipidomic studies on the intervention of taurochenodeoxycholic acid in mice with hyperlipidemia |
| title_short | Metabolomic and lipidomic studies on the intervention of taurochenodeoxycholic acid in mice with hyperlipidemia |
| title_sort | metabolomic and lipidomic studies on the intervention of taurochenodeoxycholic acid in mice with hyperlipidemia |
| topic | taurochenodeoxycholic acid hyperlipidemia metabolomics lipidomics glycerophospholipid metabolism |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1255931/full |
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