Bioactive Olivacine Derivatives—Potential Application in Cancer Therapy
Olivacine and its derivatives are characterized by multidirectional biological activity. Noteworthy is their antiproliferative effect related to various mechanisms, such as inhibition of growth factors, enzymes, kinases and others. The activity of these compounds was tested on cell lines of various...
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MDPI AG
2021-06-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/10/6/564 |
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| author | Beata Tylińska Benita Wiatrak |
| author_facet | Beata Tylińska Benita Wiatrak |
| author_sort | Beata Tylińska |
| collection | DOAJ |
| description | Olivacine and its derivatives are characterized by multidirectional biological activity. Noteworthy is their antiproliferative effect related to various mechanisms, such as inhibition of growth factors, enzymes, kinases and others. The activity of these compounds was tested on cell lines of various tumors. In most publications, the most active olivacine derivatives exceeded the effects of doxorubicin (a commonly used anticancer drug), so in the future, they may become the main new anticancer drugs. In this publication, we present the groups of the most active olivacine derivatives obtained. In this work, the in vitro and in vivo activity of olivacine and its most active derivatives are presented. We describe olivacine derivatives that have been in clinical trials. We conducted a structure–activity relationship (SAR) analysis that may be used to obtain new olivacine derivatives with better properties than the available anticancer drugs. |
| first_indexed | 2024-03-10T10:12:43Z |
| format | Article |
| id | doaj.art-7f4ed05834af4fe787ca1b92615f6eac |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-10T10:12:43Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-7f4ed05834af4fe787ca1b92615f6eac2023-11-22T01:04:10ZengMDPI AGBiology2079-77372021-06-0110656410.3390/biology10060564Bioactive Olivacine Derivatives—Potential Application in Cancer TherapyBeata Tylińska0Benita Wiatrak1Department of Organic Chemistry, Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wroclaw, PolandDepartment of Pharmacology, Faculty of Medicine, Wroclaw Medical University, 50-345 Wroclaw, PolandOlivacine and its derivatives are characterized by multidirectional biological activity. Noteworthy is their antiproliferative effect related to various mechanisms, such as inhibition of growth factors, enzymes, kinases and others. The activity of these compounds was tested on cell lines of various tumors. In most publications, the most active olivacine derivatives exceeded the effects of doxorubicin (a commonly used anticancer drug), so in the future, they may become the main new anticancer drugs. In this publication, we present the groups of the most active olivacine derivatives obtained. In this work, the in vitro and in vivo activity of olivacine and its most active derivatives are presented. We describe olivacine derivatives that have been in clinical trials. We conducted a structure–activity relationship (SAR) analysis that may be used to obtain new olivacine derivatives with better properties than the available anticancer drugs.https://www.mdpi.com/2079-7737/10/6/564olivacinepyridocarbazolecytostaticS16020antitumorin vitro |
| spellingShingle | Beata Tylińska Benita Wiatrak Bioactive Olivacine Derivatives—Potential Application in Cancer Therapy Biology olivacine pyridocarbazole cytostatic S16020 antitumor in vitro |
| title | Bioactive Olivacine Derivatives—Potential Application in Cancer Therapy |
| title_full | Bioactive Olivacine Derivatives—Potential Application in Cancer Therapy |
| title_fullStr | Bioactive Olivacine Derivatives—Potential Application in Cancer Therapy |
| title_full_unstemmed | Bioactive Olivacine Derivatives—Potential Application in Cancer Therapy |
| title_short | Bioactive Olivacine Derivatives—Potential Application in Cancer Therapy |
| title_sort | bioactive olivacine derivatives potential application in cancer therapy |
| topic | olivacine pyridocarbazole cytostatic S16020 antitumor in vitro |
| url | https://www.mdpi.com/2079-7737/10/6/564 |
| work_keys_str_mv | AT beatatylinska bioactiveolivacinederivativespotentialapplicationincancertherapy AT benitawiatrak bioactiveolivacinederivativespotentialapplicationincancertherapy |