HMPV in Immunocompromised Patients: Frequency and Severity in Pediatric Oncology Patients
Cancer is the first cause of death by disease in childhood globally. The most frequent types of cancers in children and adolescents are leukemias, followed by brain and central nervous system tumors and lymphomas. The recovery rate of cancer in children is around 80% in developed countries and up to...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-01-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/9/1/51 |
| _version_ | 1811303510666379264 |
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| author | Cesar Martinez-Rodriguez Ma. del Rocio Banos-Lara |
| author_facet | Cesar Martinez-Rodriguez Ma. del Rocio Banos-Lara |
| author_sort | Cesar Martinez-Rodriguez |
| collection | DOAJ |
| description | Cancer is the first cause of death by disease in childhood globally. The most frequent types of cancers in children and adolescents are leukemias, followed by brain and central nervous system tumors and lymphomas. The recovery rate of cancer in children is around 80% in developed countries and up to 30% in developing countries. Some of the main causes of complications in children and adolescents with cancer are respiratory viral infections, mainly in bone marrow-transplanted patients. Respiratory viruses have been detected in the bronchoalveolar lavage or nasal wash specimens from cancer patients with or without respiratory illness symptoms. Human metapneumovirus (HMPV) is within the ten most common viruses that are encountered in samples from pediatric patients with underlying oncology conditions. In most of cases, HMPV is found as the only viral agent, but co-infection with other viruses or with bacterial agents has also been reported. The discrepancies between the most prevalent viral agents may be due to the different populations studied or the range of viral agents tested. Some of the cases of infection with HMPV in cancer patients have been fatal, especially in those who have received a hematopoietic stem cell transplant. This review seeks to show a general view of the participation of HMPV in respiratory illness as a complication of cancer in childhood and adolescence. |
| first_indexed | 2024-04-13T07:49:11Z |
| format | Article |
| id | doaj.art-7f513534346048e0b2fc7a9d1274463a |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-04-13T07:49:11Z |
| publishDate | 2020-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-7f513534346048e0b2fc7a9d1274463a2022-12-22T02:55:36ZengMDPI AGPathogens2076-08172020-01-01915110.3390/pathogens9010051pathogens9010051HMPV in Immunocompromised Patients: Frequency and Severity in Pediatric Oncology PatientsCesar Martinez-Rodriguez0Ma. del Rocio Banos-Lara1School of Medicine. Instituto Universitario de Ciencias Médicas y Humanísticas de Nayarit; Tepic 63190, MexicoCentro de Investigación Oncológica Una Nueva Esperanza-Universidad Popular Autónoma del Estado de Puebla; Universidad Popular Autónoma del Estado de Puebla, 21 sur #1103, Barrio de Santiago, Puebla 72410, MexicoCancer is the first cause of death by disease in childhood globally. The most frequent types of cancers in children and adolescents are leukemias, followed by brain and central nervous system tumors and lymphomas. The recovery rate of cancer in children is around 80% in developed countries and up to 30% in developing countries. Some of the main causes of complications in children and adolescents with cancer are respiratory viral infections, mainly in bone marrow-transplanted patients. Respiratory viruses have been detected in the bronchoalveolar lavage or nasal wash specimens from cancer patients with or without respiratory illness symptoms. Human metapneumovirus (HMPV) is within the ten most common viruses that are encountered in samples from pediatric patients with underlying oncology conditions. In most of cases, HMPV is found as the only viral agent, but co-infection with other viruses or with bacterial agents has also been reported. The discrepancies between the most prevalent viral agents may be due to the different populations studied or the range of viral agents tested. Some of the cases of infection with HMPV in cancer patients have been fatal, especially in those who have received a hematopoietic stem cell transplant. This review seeks to show a general view of the participation of HMPV in respiratory illness as a complication of cancer in childhood and adolescence.https://www.mdpi.com/2076-0817/9/1/51pediatric cancer infectionshmpvfatal cases in hsct patients |
| spellingShingle | Cesar Martinez-Rodriguez Ma. del Rocio Banos-Lara HMPV in Immunocompromised Patients: Frequency and Severity in Pediatric Oncology Patients Pathogens pediatric cancer infections hmpv fatal cases in hsct patients |
| title | HMPV in Immunocompromised Patients: Frequency and Severity in Pediatric Oncology Patients |
| title_full | HMPV in Immunocompromised Patients: Frequency and Severity in Pediatric Oncology Patients |
| title_fullStr | HMPV in Immunocompromised Patients: Frequency and Severity in Pediatric Oncology Patients |
| title_full_unstemmed | HMPV in Immunocompromised Patients: Frequency and Severity in Pediatric Oncology Patients |
| title_short | HMPV in Immunocompromised Patients: Frequency and Severity in Pediatric Oncology Patients |
| title_sort | hmpv in immunocompromised patients frequency and severity in pediatric oncology patients |
| topic | pediatric cancer infections hmpv fatal cases in hsct patients |
| url | https://www.mdpi.com/2076-0817/9/1/51 |
| work_keys_str_mv | AT cesarmartinezrodriguez hmpvinimmunocompromisedpatientsfrequencyandseverityinpediatriconcologypatients AT madelrociobanoslara hmpvinimmunocompromisedpatientsfrequencyandseverityinpediatriconcologypatients |