TOX3 Gene polymorphisms and breast cancer; effects and implications of the variations: review article
Breast carcinoma is the most common cause of cancer mortality among women globally. Primary and secondary prevention through avoiding known risk factors, screening for early detection of tumors with different methods as well as timely treatment, can be effective in reduction of the burden of this de...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | fas |
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Tehran University of Medical Sciences
2017-08-01
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| Series: | Tehran University Medical Journal |
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| Online Access: | http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-5592&slc_lang=en&sid=1 |
| _version_ | 1811261046933946368 |
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| author | Amir Tajbakhsh Fahimeh Afzal Javan Mostafa Fazeli Mahdi Rivandi Mohammad Mahdi Kushyar Mohammadreza Nassiri Alireza Pasdar |
| author_facet | Amir Tajbakhsh Fahimeh Afzal Javan Mostafa Fazeli Mahdi Rivandi Mohammad Mahdi Kushyar Mohammadreza Nassiri Alireza Pasdar |
| author_sort | Amir Tajbakhsh |
| collection | DOAJ |
| description | Breast carcinoma is the most common cause of cancer mortality among women globally. Primary and secondary prevention through avoiding known risk factors, screening for early detection of tumors with different methods as well as timely treatment, can be effective in reduction of the burden of this devastating disease. This can in turn prevent death and also increase survival in patients with breast cancer. Both environmental and genetic factors are involved in the pathogenesis of breast cancer. Multiple genetic factors can influence the risk and development of breast cancer. Identification of genetic variants including single nucleotide polymorphisms (SNPs), which are associated with the risk of breast cancer development, are mostly done through genetic association studies. It is demonstrated that SNP allele frequencies vary amongst different populations. It has been shown that genetic risk factors like variations in TOX high mobility group box family member 3 (TOX3), which affect the liability for neoplasm, play an important role in the development of breast cancer. Although TOX3 is expressed mainly in the brain, its expression in other tissues especially breast has also been reported. TOX3 maps to chromosome 16q12 and encodes the nuclear high-mobility group (HMG)-box. It has calcium (Ca2+)-dependent transcriptional activities and is a co-factor of cAMP response element (CRE)-binding protein (CREB) and CREB-binding protein (CBP). TOX3, activated with Ca2+, is related with activation of the promoter of some other genes including BCL2 and C3 complement and also CITED1 gene expression. It also induces activation of the c-fos promoter and therefore its expression. Genome-wide association studies (GWAS) in different populations including European, Asian and African-American have demonstrated that a SNP near its 5ʹ end and the promoter of TOX3 gene appears to be significantly associated with breast cancer susceptibility. Furthermore, breast cancer–associated SNPs lead to enhanced FOXA1 bindings and in turn, a reduction in TOX3 gene expression. This review has highlighted the importance of TOX3 function, SNPs and its association with breast cancer risk and also its potential effects on breast cancer treatment; TOX3 plays dual and somehow conflicting roles in cancer initiation and progression which remains to be further investigated. |
| first_indexed | 2024-04-12T18:57:44Z |
| format | Article |
| id | doaj.art-7f521566f0fc45cc8613c89c2af35f1c |
| institution | Directory Open Access Journal |
| issn | 1683-1764 1735-7322 |
| language | fas |
| last_indexed | 2024-04-12T18:57:44Z |
| publishDate | 2017-08-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Tehran University Medical Journal |
| spelling | doaj.art-7f521566f0fc45cc8613c89c2af35f1c2022-12-22T03:20:17ZfasTehran University of Medical SciencesTehran University Medical Journal1683-17641735-73222017-08-01755323331TOX3 Gene polymorphisms and breast cancer; effects and implications of the variations: review articleAmir Tajbakhsh0Fahimeh Afzal Javan1Mostafa Fazeli2Mahdi Rivandi3Mohammad Mahdi Kushyar4Mohammadreza Nassiri5Alireza Pasdar6 Department of Modern Sciences & Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Student Research Committee, Department of Modern Sciences & Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Modern Sciences & Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Student Research Committee, Department of Modern Sciences & Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Modern Sciences & Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Student Research Committee, Department of Modern Sciences & Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Modern Sciences & Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Student Research Committee, Department of Modern Sciences & Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Hematology-Oncology, Emam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. Biotechnology Institute, Ferdowsi University of Mashhad, Mashhad, Iran. Medical Genetics Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Division of Applied Medicine, Faculty of Medicine, University of Aberdeen, Foresterhill, Aberdeen, UK. Breast carcinoma is the most common cause of cancer mortality among women globally. Primary and secondary prevention through avoiding known risk factors, screening for early detection of tumors with different methods as well as timely treatment, can be effective in reduction of the burden of this devastating disease. This can in turn prevent death and also increase survival in patients with breast cancer. Both environmental and genetic factors are involved in the pathogenesis of breast cancer. Multiple genetic factors can influence the risk and development of breast cancer. Identification of genetic variants including single nucleotide polymorphisms (SNPs), which are associated with the risk of breast cancer development, are mostly done through genetic association studies. It is demonstrated that SNP allele frequencies vary amongst different populations. It has been shown that genetic risk factors like variations in TOX high mobility group box family member 3 (TOX3), which affect the liability for neoplasm, play an important role in the development of breast cancer. Although TOX3 is expressed mainly in the brain, its expression in other tissues especially breast has also been reported. TOX3 maps to chromosome 16q12 and encodes the nuclear high-mobility group (HMG)-box. It has calcium (Ca2+)-dependent transcriptional activities and is a co-factor of cAMP response element (CRE)-binding protein (CREB) and CREB-binding protein (CBP). TOX3, activated with Ca2+, is related with activation of the promoter of some other genes including BCL2 and C3 complement and also CITED1 gene expression. It also induces activation of the c-fos promoter and therefore its expression. Genome-wide association studies (GWAS) in different populations including European, Asian and African-American have demonstrated that a SNP near its 5ʹ end and the promoter of TOX3 gene appears to be significantly associated with breast cancer susceptibility. Furthermore, breast cancer–associated SNPs lead to enhanced FOXA1 bindings and in turn, a reduction in TOX3 gene expression. This review has highlighted the importance of TOX3 function, SNPs and its association with breast cancer risk and also its potential effects on breast cancer treatment; TOX3 plays dual and somehow conflicting roles in cancer initiation and progression which remains to be further investigated.http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-5592&slc_lang=en&sid=1breast neoplasms genetic predisposition to disease risk factors single nucleotide polymorphisms TOX3 |
| spellingShingle | Amir Tajbakhsh Fahimeh Afzal Javan Mostafa Fazeli Mahdi Rivandi Mohammad Mahdi Kushyar Mohammadreza Nassiri Alireza Pasdar TOX3 Gene polymorphisms and breast cancer; effects and implications of the variations: review article Tehran University Medical Journal breast neoplasms genetic predisposition to disease risk factors single nucleotide polymorphisms TOX3 |
| title | TOX3 Gene polymorphisms and breast cancer; effects and implications of the variations: review article |
| title_full | TOX3 Gene polymorphisms and breast cancer; effects and implications of the variations: review article |
| title_fullStr | TOX3 Gene polymorphisms and breast cancer; effects and implications of the variations: review article |
| title_full_unstemmed | TOX3 Gene polymorphisms and breast cancer; effects and implications of the variations: review article |
| title_short | TOX3 Gene polymorphisms and breast cancer; effects and implications of the variations: review article |
| title_sort | tox3 gene polymorphisms and breast cancer effects and implications of the variations review article |
| topic | breast neoplasms genetic predisposition to disease risk factors single nucleotide polymorphisms TOX3 |
| url | http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-5592&slc_lang=en&sid=1 |
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