Prevalence and severity of ocular surface Neoplasia in African nations and need for early interventions
Ocular surface squamous neoplasia (OSSN) is a common ocular surface tumor with an increased incidence in African countries (3.4 and 3.0 cases/year/100,000). Despite its potential for vision loss and death, OSSN remains largely neglected by both eye and HIV care programs in Africa. The purpose of thi...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Knowledge E
2016-01-01
|
| Series: | Journal of Ophthalmic & Vision Research |
| Subjects: | |
| Online Access: | http://www.jovr.org/article.asp?issn=2008-322X;year=2016;volume=11;issue=4;spage=415;epage=421;aulast=Reynolds |
| _version_ | 1811194040551473152 |
|---|---|
| author | Jacob W Reynolds Margaret L Pfeiffer Omar Ozgur Bita Esmaeli |
| author_facet | Jacob W Reynolds Margaret L Pfeiffer Omar Ozgur Bita Esmaeli |
| author_sort | Jacob W Reynolds |
| collection | DOAJ |
| description | Ocular surface squamous neoplasia (OSSN) is a common ocular surface tumor with an increased incidence in African countries (3.4 and 3.0 cases/year/100,000). Despite its potential for vision loss and death, OSSN remains largely neglected by both eye and HIV care programs in Africa. The purpose of this review is to identify the barriers to timely diagnosis and early interventions for OSSN in Africa. PubMed searches were conducted targeting previous use of topical chemotherapy (interferon alpha 2b, Mitomycin-C, 5-Fluorouracil) and Human papillomavirus (HPV) vaccination in Africa. We found that OSSN is a significant vision and life-threatening health problem in Africa leading to significant loss of vision, as well as facial disfigurement and social stigma. We did not find any reports on the use of topical interferon, Mitomycin-C or HPV vaccination for OSSN in Africa. One report on the use of topical 5-FU for OSSN in Africa was found. Common barriers to early detection and management of OSSN in Africa include lack of sufficient laboratory infrastructure, lack of trained healthcare personnel, lack of compliance with follow-up visits, cost of topical chemotherapies, and cultural preferences for traditional medicines. In conclusion, OSSN is a significant vision and life-threatening health problem in Africa. There is not much literature on prevention or treatment options for early stages of OSSN in Africa. The use of topical chemotherapy as early interventions and judicious use of smart phone Apps to help with remote diagnosis of early OSSN should be further explored. |
| first_indexed | 2024-04-12T00:19:07Z |
| format | Article |
| id | doaj.art-7f5380ab79cd4b9f85336005e9f2dacc |
| institution | Directory Open Access Journal |
| issn | 2008-322X |
| language | English |
| last_indexed | 2024-04-12T00:19:07Z |
| publishDate | 2016-01-01 |
| publisher | Knowledge E |
| record_format | Article |
| series | Journal of Ophthalmic & Vision Research |
| spelling | doaj.art-7f5380ab79cd4b9f85336005e9f2dacc2022-12-22T03:55:45ZengKnowledge EJournal of Ophthalmic & Vision Research2008-322X2016-01-0111441542110.4103/2008-322X.194139Prevalence and severity of ocular surface Neoplasia in African nations and need for early interventionsJacob W ReynoldsMargaret L PfeifferOmar OzgurBita EsmaeliOcular surface squamous neoplasia (OSSN) is a common ocular surface tumor with an increased incidence in African countries (3.4 and 3.0 cases/year/100,000). Despite its potential for vision loss and death, OSSN remains largely neglected by both eye and HIV care programs in Africa. The purpose of this review is to identify the barriers to timely diagnosis and early interventions for OSSN in Africa. PubMed searches were conducted targeting previous use of topical chemotherapy (interferon alpha 2b, Mitomycin-C, 5-Fluorouracil) and Human papillomavirus (HPV) vaccination in Africa. We found that OSSN is a significant vision and life-threatening health problem in Africa leading to significant loss of vision, as well as facial disfigurement and social stigma. We did not find any reports on the use of topical interferon, Mitomycin-C or HPV vaccination for OSSN in Africa. One report on the use of topical 5-FU for OSSN in Africa was found. Common barriers to early detection and management of OSSN in Africa include lack of sufficient laboratory infrastructure, lack of trained healthcare personnel, lack of compliance with follow-up visits, cost of topical chemotherapies, and cultural preferences for traditional medicines. In conclusion, OSSN is a significant vision and life-threatening health problem in Africa. There is not much literature on prevention or treatment options for early stages of OSSN in Africa. The use of topical chemotherapy as early interventions and judicious use of smart phone Apps to help with remote diagnosis of early OSSN should be further explored.http://www.jovr.org/article.asp?issn=2008-322X;year=2016;volume=11;issue=4;spage=415;epage=421;aulast=ReynoldsAfrica; HIV; Ocular Surface Squamous Neoplasia; Topical Chemotherapy |
| spellingShingle | Jacob W Reynolds Margaret L Pfeiffer Omar Ozgur Bita Esmaeli Prevalence and severity of ocular surface Neoplasia in African nations and need for early interventions Journal of Ophthalmic & Vision Research Africa; HIV; Ocular Surface Squamous Neoplasia; Topical Chemotherapy |
| title | Prevalence and severity of ocular surface Neoplasia in African nations and need for early interventions |
| title_full | Prevalence and severity of ocular surface Neoplasia in African nations and need for early interventions |
| title_fullStr | Prevalence and severity of ocular surface Neoplasia in African nations and need for early interventions |
| title_full_unstemmed | Prevalence and severity of ocular surface Neoplasia in African nations and need for early interventions |
| title_short | Prevalence and severity of ocular surface Neoplasia in African nations and need for early interventions |
| title_sort | prevalence and severity of ocular surface neoplasia in african nations and need for early interventions |
| topic | Africa; HIV; Ocular Surface Squamous Neoplasia; Topical Chemotherapy |
| url | http://www.jovr.org/article.asp?issn=2008-322X;year=2016;volume=11;issue=4;spage=415;epage=421;aulast=Reynolds |
| work_keys_str_mv | AT jacobwreynolds prevalenceandseverityofocularsurfaceneoplasiainafricannationsandneedforearlyinterventions AT margaretlpfeiffer prevalenceandseverityofocularsurfaceneoplasiainafricannationsandneedforearlyinterventions AT omarozgur prevalenceandseverityofocularsurfaceneoplasiainafricannationsandneedforearlyinterventions AT bitaesmaeli prevalenceandseverityofocularsurfaceneoplasiainafricannationsandneedforearlyinterventions |