Extracellular Vesicles: New Players in the Mechanisms of Sepsis- and COVID-19-Related Thromboinflammation
Sepsis and COVID-19 patients often manifest an imbalance in inflammation and coagulation, a complex pathological mechanism also named thromboinflammation, which strongly affects patient prognosis. Extracellular vesicles (EVs) are nanoparticles released by cells into extracellular space that have a r...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/3/1920 |
| _version_ | 1797624478018043904 |
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| author | Martina Schiavello Barbara Vizio Ornella Bosco Emanuele Pivetta Filippo Mariano Giuseppe Montrucchio Enrico Lupia |
| author_facet | Martina Schiavello Barbara Vizio Ornella Bosco Emanuele Pivetta Filippo Mariano Giuseppe Montrucchio Enrico Lupia |
| author_sort | Martina Schiavello |
| collection | DOAJ |
| description | Sepsis and COVID-19 patients often manifest an imbalance in inflammation and coagulation, a complex pathological mechanism also named thromboinflammation, which strongly affects patient prognosis. Extracellular vesicles (EVs) are nanoparticles released by cells into extracellular space that have a relevant role in cell-to-cell communication. Recently, EVs have been shown to act as important players in a variety of pathologies, including cancer and cardiovascular disease. The biological properties of EVs in the mechanisms of thromboinflammation during sepsis and COVID-19 are still only partially known. Herein, we summarize the current experimental evidence on the role of EVs in thromboinflammation, both in bacterial sepsis and in COVID-19. A better understanding of EV involvement in these processes could be useful in describing novel diagnostic and therapeutic applications of EVs in these diseases. |
| first_indexed | 2024-03-11T09:42:54Z |
| format | Article |
| id | doaj.art-7f55b7a13d704b6ab3e31b04d76dd8c4 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T09:42:54Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-7f55b7a13d704b6ab3e31b04d76dd8c42023-11-16T16:49:41ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-01-01243192010.3390/ijms24031920Extracellular Vesicles: New Players in the Mechanisms of Sepsis- and COVID-19-Related ThromboinflammationMartina Schiavello0Barbara Vizio1Ornella Bosco2Emanuele Pivetta3Filippo Mariano4Giuseppe Montrucchio5Enrico Lupia6Department of Medical Science, University of Turin, 10126 Turin, ItalyDepartment of Medical Science, University of Turin, 10126 Turin, ItalyDepartment of Medical Science, University of Turin, 10126 Turin, ItalyDepartment of Medical Science, University of Turin, 10126 Turin, ItalyDepartment of Medical Science, University of Turin, 10126 Turin, ItalyDepartment of Medical Science, University of Turin, 10126 Turin, ItalyDepartment of Medical Science, University of Turin, 10126 Turin, ItalySepsis and COVID-19 patients often manifest an imbalance in inflammation and coagulation, a complex pathological mechanism also named thromboinflammation, which strongly affects patient prognosis. Extracellular vesicles (EVs) are nanoparticles released by cells into extracellular space that have a relevant role in cell-to-cell communication. Recently, EVs have been shown to act as important players in a variety of pathologies, including cancer and cardiovascular disease. The biological properties of EVs in the mechanisms of thromboinflammation during sepsis and COVID-19 are still only partially known. Herein, we summarize the current experimental evidence on the role of EVs in thromboinflammation, both in bacterial sepsis and in COVID-19. A better understanding of EV involvement in these processes could be useful in describing novel diagnostic and therapeutic applications of EVs in these diseases.https://www.mdpi.com/1422-0067/24/3/1920extracellular vesiclessepsisCOVID-19thromboinflammation |
| spellingShingle | Martina Schiavello Barbara Vizio Ornella Bosco Emanuele Pivetta Filippo Mariano Giuseppe Montrucchio Enrico Lupia Extracellular Vesicles: New Players in the Mechanisms of Sepsis- and COVID-19-Related Thromboinflammation International Journal of Molecular Sciences extracellular vesicles sepsis COVID-19 thromboinflammation |
| title | Extracellular Vesicles: New Players in the Mechanisms of Sepsis- and COVID-19-Related Thromboinflammation |
| title_full | Extracellular Vesicles: New Players in the Mechanisms of Sepsis- and COVID-19-Related Thromboinflammation |
| title_fullStr | Extracellular Vesicles: New Players in the Mechanisms of Sepsis- and COVID-19-Related Thromboinflammation |
| title_full_unstemmed | Extracellular Vesicles: New Players in the Mechanisms of Sepsis- and COVID-19-Related Thromboinflammation |
| title_short | Extracellular Vesicles: New Players in the Mechanisms of Sepsis- and COVID-19-Related Thromboinflammation |
| title_sort | extracellular vesicles new players in the mechanisms of sepsis and covid 19 related thromboinflammation |
| topic | extracellular vesicles sepsis COVID-19 thromboinflammation |
| url | https://www.mdpi.com/1422-0067/24/3/1920 |
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