Oncogenic Activation of Nrf2, Though as a Master Antioxidant Transcription Factor, Liberated by Specific Knockout of the Full-Length Nrf1α that Acts as a Dominant Tumor Repressor

Oncogenic Activation of Nrf2, Though as a Master Antioxidant Transcription Factor, Liberated by Specific Knockout of the Full-Length Nrf1α that Acts as a Dominant Tumor Repressor

Liver-specific knockout of Nrf1 in the mouse leads to spontaneous development of non- alcoholic steatohepatitis with dyslipidemia, and then its deterioration results in hepatoma, but the underlying mechanism remains elusive to date. A similar pathological model is reconstructed here by using human N...

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Bibliographic Details
Main Authors: Lu Qiu, Meng Wang, Shaofan Hu, Xufang Ru, Yonggang Ren, Zhengwen Zhang, Siwang Yu, Yiguo Zhang
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Cancers
Subjects:
Nrf1α
Nrf2
Keap1
PTEN
COX1
COX2
AP-1
miR-22
proteasome
tumor repressor
tumor promoter
regulatory networks
non-alcoholic steatohepatitis
hepatoma
oxidative stress
Online Access:https://www.mdpi.com/2072-6694/10/12/520

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