Efficacy of an eye drop mixture for pupillary dilatation: A randomized comparative study
Purpose: Pupillary dilatation with three types of eye drops is used regularly in the clinic; however, a mixture of these drops in a single bottle may be more beneficial in reducing workloads and resources. This study compared the efficacy in pupillary dilatation between two protocols of dilating dro...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-04-01
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| Series: | Journal of Optometry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1888429616300231 |
| _version_ | 1819160962144403456 |
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| author | Patama Bhurayanontachai Suwapat Saengkaew Penjamaporn Apiromruck |
| author_facet | Patama Bhurayanontachai Suwapat Saengkaew Penjamaporn Apiromruck |
| author_sort | Patama Bhurayanontachai |
| collection | DOAJ |
| description | Purpose: Pupillary dilatation with three types of eye drops is used regularly in the clinic; however, a mixture of these drops in a single bottle may be more beneficial in reducing workloads and resources. This study compared the efficacy in pupillary dilatation between two protocols of dilating drop instillation.
Methods: This prospective, randomized, comparative study included 30 eligible Thai patients. The patients randomly received preoperative pupillary dilatations by either the conventional protocol (1% tropicamide (T), 10% phenylephrine (P) and 0.1% diclofenac (D) in three separate bottles) or the fixed combination (TPD) protocol which had the three types of eye drops mixed in a single bottle in a ratio of 4:3:3. The chi-square test and independent t-test were used to analyze the data.
Results: The conventional protocol group and TPD protocol group each had 15 patients. Sixty minutes after the initial instillation, all patients in the TPD protocol and 13 patients (86.7%) in conventional protocol achieved at least 6 mm in the shortest diameter. The mydriatic rate between protocols showed no difference. In patients who received the TPD protocol, the systemic effects on the mean arterial blood pressure and pulse rate decreased over time.
Conclusion: The mixture of tropicamide, phenylephrine and diclofenac had a comparable efficacy for a pupillary dilatation to the conventional dilating drops in separate bottles. The systemic complications on blood pressure and arterial pulse of the TPD mixture were less than the conventional protocol.
Trial registration: TCTR20130325001. |
| first_indexed | 2024-12-22T17:04:46Z |
| format | Article |
| id | doaj.art-7f5a45e754fe42b28120f53b3ea15d9d |
| institution | Directory Open Access Journal |
| issn | 1888-4296 |
| language | English |
| last_indexed | 2024-12-22T17:04:46Z |
| publishDate | 2017-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Optometry |
| spelling | doaj.art-7f5a45e754fe42b28120f53b3ea15d9d2022-12-21T18:19:13ZengElsevierJournal of Optometry1888-42962017-04-0110211111610.1016/j.optom.2016.04.007Efficacy of an eye drop mixture for pupillary dilatation: A randomized comparative studyPatama Bhurayanontachai0Suwapat Saengkaew1Penjamaporn Apiromruck2Department of Ophthalmology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, ThailandSongklanagarind Hospital, Hat Yai, Songkhla 90110, ThailandSongklanagarind Hospital, Hat Yai, Songkhla 90110, ThailandPurpose: Pupillary dilatation with three types of eye drops is used regularly in the clinic; however, a mixture of these drops in a single bottle may be more beneficial in reducing workloads and resources. This study compared the efficacy in pupillary dilatation between two protocols of dilating drop instillation. Methods: This prospective, randomized, comparative study included 30 eligible Thai patients. The patients randomly received preoperative pupillary dilatations by either the conventional protocol (1% tropicamide (T), 10% phenylephrine (P) and 0.1% diclofenac (D) in three separate bottles) or the fixed combination (TPD) protocol which had the three types of eye drops mixed in a single bottle in a ratio of 4:3:3. The chi-square test and independent t-test were used to analyze the data. Results: The conventional protocol group and TPD protocol group each had 15 patients. Sixty minutes after the initial instillation, all patients in the TPD protocol and 13 patients (86.7%) in conventional protocol achieved at least 6 mm in the shortest diameter. The mydriatic rate between protocols showed no difference. In patients who received the TPD protocol, the systemic effects on the mean arterial blood pressure and pulse rate decreased over time. Conclusion: The mixture of tropicamide, phenylephrine and diclofenac had a comparable efficacy for a pupillary dilatation to the conventional dilating drops in separate bottles. The systemic complications on blood pressure and arterial pulse of the TPD mixture were less than the conventional protocol. Trial registration: TCTR20130325001.http://www.sciencedirect.com/science/article/pii/S1888429616300231DiclofenacMydriaticPhenylephrinePupillary dilatationTropicamide |
| spellingShingle | Patama Bhurayanontachai Suwapat Saengkaew Penjamaporn Apiromruck Efficacy of an eye drop mixture for pupillary dilatation: A randomized comparative study Journal of Optometry Diclofenac Mydriatic Phenylephrine Pupillary dilatation Tropicamide |
| title | Efficacy of an eye drop mixture for pupillary dilatation: A randomized comparative study |
| title_full | Efficacy of an eye drop mixture for pupillary dilatation: A randomized comparative study |
| title_fullStr | Efficacy of an eye drop mixture for pupillary dilatation: A randomized comparative study |
| title_full_unstemmed | Efficacy of an eye drop mixture for pupillary dilatation: A randomized comparative study |
| title_short | Efficacy of an eye drop mixture for pupillary dilatation: A randomized comparative study |
| title_sort | efficacy of an eye drop mixture for pupillary dilatation a randomized comparative study |
| topic | Diclofenac Mydriatic Phenylephrine Pupillary dilatation Tropicamide |
| url | http://www.sciencedirect.com/science/article/pii/S1888429616300231 |
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