The effects of synbiotic supplementation on blood pressure and other maternal outcomes in pregnant mothers with mild preeclampsia: a triple-blinded randomized controlled trial
Abstract Introduction Preeclampsia affects a significant percentage of pregnancies which is a leading cause of premature birth. Probiotics have the potential to affect inflammatory factors, and oxidative stress, which are linked to the development of preeclampsia. The study aimed to compare the effe...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Women's Health |
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| Online Access: | https://doi.org/10.1186/s12905-024-02922-6 |
| _version_ | 1797273395268681728 |
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| author | Rouhina Movaghar Shamci Abbasalizadeh Shabnam Vazifekhah Azizeh Farshbaf-Khalili Mahnaz Shahnazi |
| author_facet | Rouhina Movaghar Shamci Abbasalizadeh Shabnam Vazifekhah Azizeh Farshbaf-Khalili Mahnaz Shahnazi |
| author_sort | Rouhina Movaghar |
| collection | DOAJ |
| description | Abstract Introduction Preeclampsia affects a significant percentage of pregnancies which is a leading cause of premature birth. Probiotics have the potential to affect inflammatory factors, and oxidative stress, which are linked to the development of preeclampsia. The study aimed to compare the effect of synbiotic and placebo on blood pressure and pregnancy duration as primary outcomes, and other pregnancy outcomes. Methods This study comprised 128 pregnant women with mild preeclampsia and gestational ages exceeding 24 weeks who were referred to the high-risk pregnancy clinic. It was a randomized, controlled, phase III, triple-blinded clinical experiment. The intervention and control groups were distributed to the participants at random. Intervention group received one oral synbiotic capsule, and control group received placebo daily until delivery. Based on gestational age at the time of diagnosis, preeclampsia was stratificated as early (< 34 weeks) or late (≥ 34 weeks). Data obtained from questionnaires, and biochemical serum factors were analyzed using SPSS software version 23 software. Results With the exception of the history of taking vitamin D3, there were no statistically significant variations in socio-demographic variables between the research groups. After the intervention, the means of systolic blood pressure (adjusted mean difference: -13.54, 95% CI: -5.01 to -22.07), and diastolic blood pressure (adjusted mean difference: -10.30, 95% CI: -4.70 to -15.90) were significantly lower in the synbiotic-supplemented group than in the placebo group. Compared to the placebo group, the incidence of severe PE (p < 0.001), proteinuria (p = 0.044), and mean serum creatinine level (p = 0.005) significantly declined in the synbiotic-supplemented group after the intervention. However, our analysis found no significant association for other outcomes. Conclusion Based on our results, synbiotic had beneficial effects on some pregnancy outcomes. Further studies with larger samples are needed to verify the advantages of synbiotic supplementation for high-risk pregnancies, particularly with regards to higher doses, and longer intervention periods. Trial registration IRCT20110606006709N20. |
| first_indexed | 2024-03-07T14:43:46Z |
| format | Article |
| id | doaj.art-7f5e00acfc324855929f2b930aa8e28d |
| institution | Directory Open Access Journal |
| issn | 1472-6874 |
| language | English |
| last_indexed | 2024-03-07T14:43:46Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Women's Health |
| spelling | doaj.art-7f5e00acfc324855929f2b930aa8e28d2024-03-05T20:08:45ZengBMCBMC Women's Health1472-68742024-01-0124111210.1186/s12905-024-02922-6The effects of synbiotic supplementation on blood pressure and other maternal outcomes in pregnant mothers with mild preeclampsia: a triple-blinded randomized controlled trialRouhina Movaghar0Shamci Abbasalizadeh1Shabnam Vazifekhah2Azizeh Farshbaf-Khalili3Mahnaz Shahnazi4Department of Midwifery, Faculty of Midwifery, Mahabad Branch Azad UniversityTabriz University of Medical Sciences, Women’s Health Research CenterUremia University of Medical SciencesPhysical Medicine and Rehabilitation Research Centre, Aging Research Institute, Tabriz University of Medical SciencesFaculty of Nursing and Midwifery, Tabriz University of Medical SciencesAbstract Introduction Preeclampsia affects a significant percentage of pregnancies which is a leading cause of premature birth. Probiotics have the potential to affect inflammatory factors, and oxidative stress, which are linked to the development of preeclampsia. The study aimed to compare the effect of synbiotic and placebo on blood pressure and pregnancy duration as primary outcomes, and other pregnancy outcomes. Methods This study comprised 128 pregnant women with mild preeclampsia and gestational ages exceeding 24 weeks who were referred to the high-risk pregnancy clinic. It was a randomized, controlled, phase III, triple-blinded clinical experiment. The intervention and control groups were distributed to the participants at random. Intervention group received one oral synbiotic capsule, and control group received placebo daily until delivery. Based on gestational age at the time of diagnosis, preeclampsia was stratificated as early (< 34 weeks) or late (≥ 34 weeks). Data obtained from questionnaires, and biochemical serum factors were analyzed using SPSS software version 23 software. Results With the exception of the history of taking vitamin D3, there were no statistically significant variations in socio-demographic variables between the research groups. After the intervention, the means of systolic blood pressure (adjusted mean difference: -13.54, 95% CI: -5.01 to -22.07), and diastolic blood pressure (adjusted mean difference: -10.30, 95% CI: -4.70 to -15.90) were significantly lower in the synbiotic-supplemented group than in the placebo group. Compared to the placebo group, the incidence of severe PE (p < 0.001), proteinuria (p = 0.044), and mean serum creatinine level (p = 0.005) significantly declined in the synbiotic-supplemented group after the intervention. However, our analysis found no significant association for other outcomes. Conclusion Based on our results, synbiotic had beneficial effects on some pregnancy outcomes. Further studies with larger samples are needed to verify the advantages of synbiotic supplementation for high-risk pregnancies, particularly with regards to higher doses, and longer intervention periods. Trial registration IRCT20110606006709N20.https://doi.org/10.1186/s12905-024-02922-6ProbioticSynbioticPre-eclampsiaPregnancy ToxemiasPregnancy hypertensionPregnancy outcomes |
| spellingShingle | Rouhina Movaghar Shamci Abbasalizadeh Shabnam Vazifekhah Azizeh Farshbaf-Khalili Mahnaz Shahnazi The effects of synbiotic supplementation on blood pressure and other maternal outcomes in pregnant mothers with mild preeclampsia: a triple-blinded randomized controlled trial BMC Women's Health Probiotic Synbiotic Pre-eclampsia Pregnancy Toxemias Pregnancy hypertension Pregnancy outcomes |
| title | The effects of synbiotic supplementation on blood pressure and other maternal outcomes in pregnant mothers with mild preeclampsia: a triple-blinded randomized controlled trial |
| title_full | The effects of synbiotic supplementation on blood pressure and other maternal outcomes in pregnant mothers with mild preeclampsia: a triple-blinded randomized controlled trial |
| title_fullStr | The effects of synbiotic supplementation on blood pressure and other maternal outcomes in pregnant mothers with mild preeclampsia: a triple-blinded randomized controlled trial |
| title_full_unstemmed | The effects of synbiotic supplementation on blood pressure and other maternal outcomes in pregnant mothers with mild preeclampsia: a triple-blinded randomized controlled trial |
| title_short | The effects of synbiotic supplementation on blood pressure and other maternal outcomes in pregnant mothers with mild preeclampsia: a triple-blinded randomized controlled trial |
| title_sort | effects of synbiotic supplementation on blood pressure and other maternal outcomes in pregnant mothers with mild preeclampsia a triple blinded randomized controlled trial |
| topic | Probiotic Synbiotic Pre-eclampsia Pregnancy Toxemias Pregnancy hypertension Pregnancy outcomes |
| url | https://doi.org/10.1186/s12905-024-02922-6 |
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