External-Beam Radiotherapy Alone Management of Primary CNS Lymphoplasmacytic Lymphoma: A Vietnamese Case Report and Literature Review
Dang Nguyen Van,1,2 Nghia Duong Van,1 Quang Le Van,1 Tung Ngo Thanh,2 To Ta Van3 1Department of Oncology, Hanoi Medical University, Hanoi, Vietnam; 2Department of Head and Neck Radiation Oncology, Vietnam National Cancer Hospital, Hanoi, Vietnam; 3Center of Pathology and Molecular Biology, Vietnam N...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-08-01
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| Series: | Journal of Blood Medicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/external-beam-radiotherapy-alone-management-of-primary-cns-lymphoplasm-peer-reviewed-fulltext-article-JBM |
| _version_ | 1819066444600573952 |
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| author | Nguyen Van D Duong Van N Le Van Q Ngo Thanh T Ta Van T |
| author_facet | Nguyen Van D Duong Van N Le Van Q Ngo Thanh T Ta Van T |
| author_sort | Nguyen Van D |
| collection | DOAJ |
| description | Dang Nguyen Van,1,2 Nghia Duong Van,1 Quang Le Van,1 Tung Ngo Thanh,2 To Ta Van3 1Department of Oncology, Hanoi Medical University, Hanoi, Vietnam; 2Department of Head and Neck Radiation Oncology, Vietnam National Cancer Hospital, Hanoi, Vietnam; 3Center of Pathology and Molecular Biology, Vietnam National Cancer Hospital, Hanoi, VietnamCorrespondence: Dang Nguyen VanDepartment of Oncology, Hanoi Medical University, 01 Ton That Tung Street, Dong Da District, Hanoi, 10000, VietnamTel +84 94 2727 899Email nguyenvandang@hmu.edu.vn; drdangnguyen@gmail.comBackground: Primary central nervous system (CNS) lymphoma is an uncommon non-Hodgkin disease limited to the CNS, and most cases are diffuse large B-cell lymphomas. Other pathologies, including lymphoplasmacytic lymphoma (LPL), are exceedingly rare and poorly understood. The clinical presentation of primary CNS LPL is diverse. It depends on the original site and the tumor’s extension. There is currently no consensus on a treatment strategy for this uncommon manifestation. To our knowledge, no previously published case was successfully treated with radiation therapy alone.Case Presentation: We present here a case of primary CNS LPL. A 46-year-old, previously healthy woman was presented with a worsening headache and lower extremity numbness. Multifocal enhanced masses were detected in an MRI with biopsy results consistent with LPL. A complete staging workup was performed with no evidence of systemic disease. The patient received external-beam radiotherapy alone and had a complete remission. After 2 years of follow-up, she remains disease-free.Conclusion: Radiation alone is a promising treatment option for primary CNS lymphoplasmacytic lymphoma.Keywords: lymphoplasmacytic lymphoma, primary CNS lymphoma, radiation therapy |
| first_indexed | 2024-12-21T16:02:28Z |
| format | Article |
| id | doaj.art-7f5e9b470c62480db73d34188a0dd9e6 |
| institution | Directory Open Access Journal |
| issn | 1179-2736 |
| language | English |
| last_indexed | 2024-12-21T16:02:28Z |
| publishDate | 2021-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Blood Medicine |
| spelling | doaj.art-7f5e9b470c62480db73d34188a0dd9e62022-12-21T18:57:58ZengDove Medical PressJournal of Blood Medicine1179-27362021-08-01Volume 1276977468086External-Beam Radiotherapy Alone Management of Primary CNS Lymphoplasmacytic Lymphoma: A Vietnamese Case Report and Literature ReviewNguyen Van DDuong Van NLe Van QNgo Thanh TTa Van TDang Nguyen Van,1,2 Nghia Duong Van,1 Quang Le Van,1 Tung Ngo Thanh,2 To Ta Van3 1Department of Oncology, Hanoi Medical University, Hanoi, Vietnam; 2Department of Head and Neck Radiation Oncology, Vietnam National Cancer Hospital, Hanoi, Vietnam; 3Center of Pathology and Molecular Biology, Vietnam National Cancer Hospital, Hanoi, VietnamCorrespondence: Dang Nguyen VanDepartment of Oncology, Hanoi Medical University, 01 Ton That Tung Street, Dong Da District, Hanoi, 10000, VietnamTel +84 94 2727 899Email nguyenvandang@hmu.edu.vn; drdangnguyen@gmail.comBackground: Primary central nervous system (CNS) lymphoma is an uncommon non-Hodgkin disease limited to the CNS, and most cases are diffuse large B-cell lymphomas. Other pathologies, including lymphoplasmacytic lymphoma (LPL), are exceedingly rare and poorly understood. The clinical presentation of primary CNS LPL is diverse. It depends on the original site and the tumor’s extension. There is currently no consensus on a treatment strategy for this uncommon manifestation. To our knowledge, no previously published case was successfully treated with radiation therapy alone.Case Presentation: We present here a case of primary CNS LPL. A 46-year-old, previously healthy woman was presented with a worsening headache and lower extremity numbness. Multifocal enhanced masses were detected in an MRI with biopsy results consistent with LPL. A complete staging workup was performed with no evidence of systemic disease. The patient received external-beam radiotherapy alone and had a complete remission. After 2 years of follow-up, she remains disease-free.Conclusion: Radiation alone is a promising treatment option for primary CNS lymphoplasmacytic lymphoma.Keywords: lymphoplasmacytic lymphoma, primary CNS lymphoma, radiation therapyhttps://www.dovepress.com/external-beam-radiotherapy-alone-management-of-primary-cns-lymphoplasm-peer-reviewed-fulltext-article-JBMlymphoplasmacytic lymphomaprimary cns lymphomaradiation therapy. |
| spellingShingle | Nguyen Van D Duong Van N Le Van Q Ngo Thanh T Ta Van T External-Beam Radiotherapy Alone Management of Primary CNS Lymphoplasmacytic Lymphoma: A Vietnamese Case Report and Literature Review Journal of Blood Medicine lymphoplasmacytic lymphoma primary cns lymphoma radiation therapy. |
| title | External-Beam Radiotherapy Alone Management of Primary CNS Lymphoplasmacytic Lymphoma: A Vietnamese Case Report and Literature Review |
| title_full | External-Beam Radiotherapy Alone Management of Primary CNS Lymphoplasmacytic Lymphoma: A Vietnamese Case Report and Literature Review |
| title_fullStr | External-Beam Radiotherapy Alone Management of Primary CNS Lymphoplasmacytic Lymphoma: A Vietnamese Case Report and Literature Review |
| title_full_unstemmed | External-Beam Radiotherapy Alone Management of Primary CNS Lymphoplasmacytic Lymphoma: A Vietnamese Case Report and Literature Review |
| title_short | External-Beam Radiotherapy Alone Management of Primary CNS Lymphoplasmacytic Lymphoma: A Vietnamese Case Report and Literature Review |
| title_sort | external beam radiotherapy alone management of primary cns lymphoplasmacytic lymphoma a vietnamese case report and literature review |
| topic | lymphoplasmacytic lymphoma primary cns lymphoma radiation therapy. |
| url | https://www.dovepress.com/external-beam-radiotherapy-alone-management-of-primary-cns-lymphoplasm-peer-reviewed-fulltext-article-JBM |
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