Tumor subtype-specific associations of hormone-related reproductive factors on breast cancer survival.
It is inconclusive whether reproductive factors, which are known as risk factors of breast cancer, also influence survival. We investigated overall and subtype-specific associations between reproductive factors and breast cancer survival.Among 3,430 incident breast cancer patients who enrolled in th...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4397050?pdf=render |
| _version_ | 1818408991817990144 |
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| author | Nan Song Ji-Yeob Choi Hyuna Sung Sujee Jeon Seokang Chung Minkyo Song Sue K Park Wonshik Han Jong Won Lee Mi Kyung Kim Keun-Young Yoo Sei-Hyun Ahn Dong-Young Noh Daehee Kang |
| author_facet | Nan Song Ji-Yeob Choi Hyuna Sung Sujee Jeon Seokang Chung Minkyo Song Sue K Park Wonshik Han Jong Won Lee Mi Kyung Kim Keun-Young Yoo Sei-Hyun Ahn Dong-Young Noh Daehee Kang |
| author_sort | Nan Song |
| collection | DOAJ |
| description | It is inconclusive whether reproductive factors, which are known as risk factors of breast cancer, also influence survival. We investigated overall and subtype-specific associations between reproductive factors and breast cancer survival.Among 3,430 incident breast cancer patients who enrolled in the Seoul Breast Cancer Study, 269 patients (7.8%) died and 528 patients (15.4%) recurred. The overall and subtype-specific associations of reproductive factors including age at menarche and menopause, duration of estrogen exposure, menstrual cycle, parity, age at first full-term pregnancy, number of children, age at last birth, time since the last birth, and duration of breastfeeding, on overall and disease-free survival (OS and DFS) were estimated by hazard ratios (HRs) and 95% confidence intervals (95% CIs) using a multivariate Cox proportional hazard model.An older age at menarche (HR for OS=1.10, 95% CI=1.03-1.19), a greater number of children (≥ 4 vs. 2, HR for DFS=1.58, 95% CI=1.11-2.26), and a shorter time since last birth (<5 vs. ≥ 20 years, HR for DFS=1.67, 95% CI=1.07-2.62) were associated with worse survival while longer duration of estrogen exposure with better survival (HR for DFS=0.97, 95% CI=0.96-0.99). In the stratified analyses by subtypes, those associations were more pronounced among women with hormone receptor and human epidermal growth factor 2 positive (HR+ HER2+) tumors.It is suggested that reproductive factors, specifically age at menarche, number of children, time since last birth, and duration of estrogen exposure, could influence breast tumor progression, especially in the HR+ HER2+ subtype. |
| first_indexed | 2024-12-14T09:52:32Z |
| format | Article |
| id | doaj.art-7f5eafde786e47a9880d93164dc5a0ef |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T09:52:32Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-7f5eafde786e47a9880d93164dc5a0ef2022-12-21T23:07:29ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01104e012399410.1371/journal.pone.0123994Tumor subtype-specific associations of hormone-related reproductive factors on breast cancer survival.Nan SongJi-Yeob ChoiHyuna SungSujee JeonSeokang ChungMinkyo SongSue K ParkWonshik HanJong Won LeeMi Kyung KimKeun-Young YooSei-Hyun AhnDong-Young NohDaehee KangIt is inconclusive whether reproductive factors, which are known as risk factors of breast cancer, also influence survival. We investigated overall and subtype-specific associations between reproductive factors and breast cancer survival.Among 3,430 incident breast cancer patients who enrolled in the Seoul Breast Cancer Study, 269 patients (7.8%) died and 528 patients (15.4%) recurred. The overall and subtype-specific associations of reproductive factors including age at menarche and menopause, duration of estrogen exposure, menstrual cycle, parity, age at first full-term pregnancy, number of children, age at last birth, time since the last birth, and duration of breastfeeding, on overall and disease-free survival (OS and DFS) were estimated by hazard ratios (HRs) and 95% confidence intervals (95% CIs) using a multivariate Cox proportional hazard model.An older age at menarche (HR for OS=1.10, 95% CI=1.03-1.19), a greater number of children (≥ 4 vs. 2, HR for DFS=1.58, 95% CI=1.11-2.26), and a shorter time since last birth (<5 vs. ≥ 20 years, HR for DFS=1.67, 95% CI=1.07-2.62) were associated with worse survival while longer duration of estrogen exposure with better survival (HR for DFS=0.97, 95% CI=0.96-0.99). In the stratified analyses by subtypes, those associations were more pronounced among women with hormone receptor and human epidermal growth factor 2 positive (HR+ HER2+) tumors.It is suggested that reproductive factors, specifically age at menarche, number of children, time since last birth, and duration of estrogen exposure, could influence breast tumor progression, especially in the HR+ HER2+ subtype.http://europepmc.org/articles/PMC4397050?pdf=render |
| spellingShingle | Nan Song Ji-Yeob Choi Hyuna Sung Sujee Jeon Seokang Chung Minkyo Song Sue K Park Wonshik Han Jong Won Lee Mi Kyung Kim Keun-Young Yoo Sei-Hyun Ahn Dong-Young Noh Daehee Kang Tumor subtype-specific associations of hormone-related reproductive factors on breast cancer survival. PLoS ONE |
| title | Tumor subtype-specific associations of hormone-related reproductive factors on breast cancer survival. |
| title_full | Tumor subtype-specific associations of hormone-related reproductive factors on breast cancer survival. |
| title_fullStr | Tumor subtype-specific associations of hormone-related reproductive factors on breast cancer survival. |
| title_full_unstemmed | Tumor subtype-specific associations of hormone-related reproductive factors on breast cancer survival. |
| title_short | Tumor subtype-specific associations of hormone-related reproductive factors on breast cancer survival. |
| title_sort | tumor subtype specific associations of hormone related reproductive factors on breast cancer survival |
| url | http://europepmc.org/articles/PMC4397050?pdf=render |
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