Factors Predicting Acute Brain Injury in Cases of Carbon Monoxide Poisoning: A Prospective Registry-Based Study
Carbon monoxide (CO) is one of the most common poisoning substances worldwide. Since acute brain injury (ABI) is an important determinant of the neurological outcome in CO poisoning, screening for patients at a high risk of developing ABI is essential for the proper treatment. This study identified...
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MDPI AG
2021-05-01
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| Series: | Toxics |
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| Online Access: | https://www.mdpi.com/2305-6304/9/6/120 |
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| author | Hoon Lim Young Hwan Lee Sangun Nah Sungwoo Choi Young Soon Cho Gi Woon Kim Ji Eun Moon Sangsoo Han |
| author_facet | Hoon Lim Young Hwan Lee Sangun Nah Sungwoo Choi Young Soon Cho Gi Woon Kim Ji Eun Moon Sangsoo Han |
| author_sort | Hoon Lim |
| collection | DOAJ |
| description | Carbon monoxide (CO) is one of the most common poisoning substances worldwide. Since acute brain injury (ABI) is an important determinant of the neurological outcome in CO poisoning, screening for patients at a high risk of developing ABI is essential for the proper treatment. This study identified predictors of ABI in patients with CO poisoning. This prospective registry-based study was conducted in patients who visited a tertiary care hospital for CO poisoning from August 2016 to June 2020. ABI was defined as the presence of acute hypoxic lesions on diffusion-weighted magnetic resonance imaging. Multiple logistic regression analysis was performed to identify the predictors of ABI. Of 231 patients, 64 (27.7%) showed ABI. Multiple logistic regression analysis showed that a Glasgow Coma Scale (GCS) score <9 at presentation (odds ratio [OR] 3.28, 95% confidence interval (CI) 1.08–10.01), creatinine level >1.2 mg/dL (OR 3.04, 95% CI 1.16–8.01), and C-reactive protein (CRP) level >9.2 mg/L (OR 4.38, 95% CI 1.41–13.65) predicted ABI in cases of acute CO poisoning. In CO poisoning, the GCS score at presentation, and serum creatinine and CRP levels, were useful predictors of ABI, and may help clinicians identify high-risk patients for whom treatment should be prioritized. |
| first_indexed | 2024-03-10T10:59:33Z |
| format | Article |
| id | doaj.art-7f6393c6a6b94a0cbc053eef65d5d40b |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-10T10:59:33Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-7f6393c6a6b94a0cbc053eef65d5d40b2023-11-21T21:36:25ZengMDPI AGToxics2305-63042021-05-019612010.3390/toxics9060120Factors Predicting Acute Brain Injury in Cases of Carbon Monoxide Poisoning: A Prospective Registry-Based StudyHoon Lim0Young Hwan Lee1Sangun Nah2Sungwoo Choi3Young Soon Cho4Gi Woon Kim5Ji Eun Moon6Sangsoo Han7Department of Emergency Medicine, Soonchunhyang University Bucheon Hospital, Bucheon 14584, KoreaDepartment of Emergency Medicine, Soonchunhyang University Bucheon Hospital, Bucheon 14584, KoreaDepartment of Emergency Medicine, Soonchunhyang University Bucheon Hospital, Bucheon 14584, KoreaDepartment of Emergency Medicine, Soonchunhyang University Bucheon Hospital, Bucheon 14584, KoreaDepartment of Emergency Medicine, Soonchunhyang University Bucheon Hospital, Bucheon 14584, KoreaDepartment of Emergency Medicine, Soonchunhyang University Bucheon Hospital, Bucheon 14584, KoreaDepartment of Biostatistics, Clinical Trial Center, Soonchunhyang University Bucheon Hospital, Bucheon 14584, KoreaDepartment of Emergency Medicine, Soonchunhyang University Bucheon Hospital, Bucheon 14584, KoreaCarbon monoxide (CO) is one of the most common poisoning substances worldwide. Since acute brain injury (ABI) is an important determinant of the neurological outcome in CO poisoning, screening for patients at a high risk of developing ABI is essential for the proper treatment. This study identified predictors of ABI in patients with CO poisoning. This prospective registry-based study was conducted in patients who visited a tertiary care hospital for CO poisoning from August 2016 to June 2020. ABI was defined as the presence of acute hypoxic lesions on diffusion-weighted magnetic resonance imaging. Multiple logistic regression analysis was performed to identify the predictors of ABI. Of 231 patients, 64 (27.7%) showed ABI. Multiple logistic regression analysis showed that a Glasgow Coma Scale (GCS) score <9 at presentation (odds ratio [OR] 3.28, 95% confidence interval (CI) 1.08–10.01), creatinine level >1.2 mg/dL (OR 3.04, 95% CI 1.16–8.01), and C-reactive protein (CRP) level >9.2 mg/L (OR 4.38, 95% CI 1.41–13.65) predicted ABI in cases of acute CO poisoning. In CO poisoning, the GCS score at presentation, and serum creatinine and CRP levels, were useful predictors of ABI, and may help clinicians identify high-risk patients for whom treatment should be prioritized.https://www.mdpi.com/2305-6304/9/6/120acute brain injurycarbon monoxide poisoningmagnetic resonance imaging |
| spellingShingle | Hoon Lim Young Hwan Lee Sangun Nah Sungwoo Choi Young Soon Cho Gi Woon Kim Ji Eun Moon Sangsoo Han Factors Predicting Acute Brain Injury in Cases of Carbon Monoxide Poisoning: A Prospective Registry-Based Study Toxics acute brain injury carbon monoxide poisoning magnetic resonance imaging |
| title | Factors Predicting Acute Brain Injury in Cases of Carbon Monoxide Poisoning: A Prospective Registry-Based Study |
| title_full | Factors Predicting Acute Brain Injury in Cases of Carbon Monoxide Poisoning: A Prospective Registry-Based Study |
| title_fullStr | Factors Predicting Acute Brain Injury in Cases of Carbon Monoxide Poisoning: A Prospective Registry-Based Study |
| title_full_unstemmed | Factors Predicting Acute Brain Injury in Cases of Carbon Monoxide Poisoning: A Prospective Registry-Based Study |
| title_short | Factors Predicting Acute Brain Injury in Cases of Carbon Monoxide Poisoning: A Prospective Registry-Based Study |
| title_sort | factors predicting acute brain injury in cases of carbon monoxide poisoning a prospective registry based study |
| topic | acute brain injury carbon monoxide poisoning magnetic resonance imaging |
| url | https://www.mdpi.com/2305-6304/9/6/120 |
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