Association of Sperm Methylation at LINE-1, Four Candidate Genes, and Nicotine/Alcohol Exposure With the Risk of Infertility

Association of Sperm Methylation at LINE-1, Four Candidate Genes, and Nicotine/Alcohol Exposure With the Risk of Infertility

In this study, we examined whether smoking and drinking affect sperm quality and the DNA methylation of the repetitive element LINE-1, MEST, P16, H19, and GNAS in sperm. Semen samples were obtained from 143 male residents in a minority-inhabited district of Guizhou province in southwest China. Quant...

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Bibliographic Details
Main Authors: Wenjing Zhang, Min Li, Feng Sun, Xuting Xu, Zhaofeng Zhang, Junwei Liu, Xiaowei Sun, Aiping Zhang, Yupei Shen, Jianhua Xu, Maohua Miao, Bin Wu, Yao Yuan, Xianliang Huang, Huijuan Shi, Jing Du
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Genetics
Subjects:
DNA methylation
nicotine/alcohol exposure
male infertility
imprint gene
sperm
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.01001/full

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