Microsurgical resection of glioblastoma guided with intraoperative fluorescein: a retrospective evaluation
Objectives. To evaluate the influence of the use of sodium fluorescein (FLS-Na) in surgery of glioblastoma (GB) on the degree of tumor resection and survival in patients treated at the National Institute of Neoplastic Diseases. Materials and methods. A total of 238 cases of GB treated between 2008 a...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | Spanish |
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Instituto Nacional de Salud
2015-09-01
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| Series: | Revista Peruana de Medicina Experimental y Salud Pública |
| Subjects: | |
| Online Access: | https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/1676 |
| _version_ | 1819162854758023168 |
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| author | Pamela García-Corrochano Carlos A. Castañeda Enrique Orrego Pedro Deza Hugo Heinicke Sandro Casavilca Miluska Castillo karen Cortez Carolina Belmar Ketty Dolores Claudio Flores Luis Ojeda |
| author_facet | Pamela García-Corrochano Carlos A. Castañeda Enrique Orrego Pedro Deza Hugo Heinicke Sandro Casavilca Miluska Castillo karen Cortez Carolina Belmar Ketty Dolores Claudio Flores Luis Ojeda |
| author_sort | Pamela García-Corrochano |
| collection | DOAJ |
| description | Objectives. To evaluate the influence of the use of sodium fluorescein (FLS-Na) in surgery of glioblastoma (GB) on the degree of tumor resection and survival in patients treated at the National Institute of Neoplastic Diseases. Materials and methods. A total of 238 cases of GB treated between 2008 and 2013 were reviewed and 150 cases of GB who underwent surgical resection with clinicopathological information and adequate follow-up were selected. Results. The mean age was 51 years, 58.7% of the cases presented a Karnofsky score of at least 90. FLS-Na was administered in 80 cases (53.3%) and a subtotal and total resection was obtained in 69 (46%) and 81 (54%) cases, respectively. The group that received FLS-Na obtained higher rates of total resection than the group operated with white light alone (77.5 vs 27.1%, p0.001). The median overall survival (OS) was higher in the group subject to total compared to subtotal resection (17 vs 7 months, p0.001). The median OS in those who received FLS-Na was higher than in those who did not (15.0 vs 8 months, p=0.003). Other factors affecting OS were age (p=0.002), the Karnofsky score (p=0.052) and radiation therapy (p=0.016) and chemotherapy (p=0.011). Conclusions. The microsurgical technique with administration of FLS-Na was associated with an increase in the rate of total resection and survival. |
| first_indexed | 2024-12-22T17:34:51Z |
| format | Article |
| id | doaj.art-7f67325028164c2a92ef6641065f2e0a |
| institution | Directory Open Access Journal |
| issn | 1726-4634 1726-4642 |
| language | Spanish |
| last_indexed | 2024-12-22T17:34:51Z |
| publishDate | 2015-09-01 |
| publisher | Instituto Nacional de Salud |
| record_format | Article |
| series | Revista Peruana de Medicina Experimental y Salud Pública |
| spelling | doaj.art-7f67325028164c2a92ef6641065f2e0a2022-12-21T18:18:31ZspaInstituto Nacional de SaludRevista Peruana de Medicina Experimental y Salud Pública1726-46341726-46422015-09-0132347147810.17843/rpmesp.2015.323.16761640Microsurgical resection of glioblastoma guided with intraoperative fluorescein: a retrospective evaluationPamela García-Corrochano0Carlos A. Castañeda1Enrique Orrego2Pedro Deza3Hugo Heinicke4Sandro Casavilca5Miluska Castillo6karen Cortez7Carolina Belmar8Ketty Dolores9Claudio Flores10Luis Ojeda11Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú.Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú.Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú.Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú.Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú.Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú.Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú.Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú.Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú.Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú.Oncosalud, AUNA. Lima, PerúInstituto Nacional de Enfermedades Neoplásicas. Lima, Perú.Objectives. To evaluate the influence of the use of sodium fluorescein (FLS-Na) in surgery of glioblastoma (GB) on the degree of tumor resection and survival in patients treated at the National Institute of Neoplastic Diseases. Materials and methods. A total of 238 cases of GB treated between 2008 and 2013 were reviewed and 150 cases of GB who underwent surgical resection with clinicopathological information and adequate follow-up were selected. Results. The mean age was 51 years, 58.7% of the cases presented a Karnofsky score of at least 90. FLS-Na was administered in 80 cases (53.3%) and a subtotal and total resection was obtained in 69 (46%) and 81 (54%) cases, respectively. The group that received FLS-Na obtained higher rates of total resection than the group operated with white light alone (77.5 vs 27.1%, p0.001). The median overall survival (OS) was higher in the group subject to total compared to subtotal resection (17 vs 7 months, p0.001). The median OS in those who received FLS-Na was higher than in those who did not (15.0 vs 8 months, p=0.003). Other factors affecting OS were age (p=0.002), the Karnofsky score (p=0.052) and radiation therapy (p=0.016) and chemotherapy (p=0.011). Conclusions. The microsurgical technique with administration of FLS-Na was associated with an increase in the rate of total resection and survival.https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/1676glioblastomafluoresceínamicrocirugiaanálisis de supervivencia |
| spellingShingle | Pamela García-Corrochano Carlos A. Castañeda Enrique Orrego Pedro Deza Hugo Heinicke Sandro Casavilca Miluska Castillo karen Cortez Carolina Belmar Ketty Dolores Claudio Flores Luis Ojeda Microsurgical resection of glioblastoma guided with intraoperative fluorescein: a retrospective evaluation Revista Peruana de Medicina Experimental y Salud Pública glioblastoma fluoresceína microcirugia análisis de supervivencia |
| title | Microsurgical resection of glioblastoma guided with intraoperative fluorescein: a retrospective evaluation |
| title_full | Microsurgical resection of glioblastoma guided with intraoperative fluorescein: a retrospective evaluation |
| title_fullStr | Microsurgical resection of glioblastoma guided with intraoperative fluorescein: a retrospective evaluation |
| title_full_unstemmed | Microsurgical resection of glioblastoma guided with intraoperative fluorescein: a retrospective evaluation |
| title_short | Microsurgical resection of glioblastoma guided with intraoperative fluorescein: a retrospective evaluation |
| title_sort | microsurgical resection of glioblastoma guided with intraoperative fluorescein a retrospective evaluation |
| topic | glioblastoma fluoresceína microcirugia análisis de supervivencia |
| url | https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/1676 |
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