Metabolic Profiling Reveals Aggravated Non-Alcoholic Steatohepatitis in High-Fat High-Cholesterol Diet-Fed Apolipoprotein E-Deficient Mice Lacking Ron Receptor Signaling

Metabolic Profiling Reveals Aggravated Non-Alcoholic Steatohepatitis in High-Fat High-Cholesterol Diet-Fed Apolipoprotein E-Deficient Mice Lacking Ron Receptor Signaling

Non-alcoholic steatohepatitis (NASH) represents the progressive sub-disease of non-alcoholic fatty liver disease that causes chronic liver injury initiated and sustained by steatosis and necroinflammation. The Ron receptor is a tyrosine kinase of the Met proto-oncogene family that potentially has a...

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Bibliographic Details
Main Authors: Joselyn N. Allen, Adwitia Dey, Jingwei Cai, Jingtao Zhang, Yuan Tian, Mary Kennett, Yanling Ma, T. Jake Liang, Andrew D. Patterson, Pamela A. Hankey-Giblin
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Metabolites
Subjects:
Ron receptor tyrosine kinase
macrophage stimulating protein (MSP)
non-alcoholic steatohepatitis
lipid metabolism
mass spectrometry
nuclear magnetic resonance
Online Access:https://www.mdpi.com/2218-1989/10/8/326

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