COVID-19 in patients with transfusion dependent thalassemia in Indonesia: characteristics of the disease and patients, and comparison between epidemiological data for COVID-19 and thalassemia in Indonesia and South-East Asia
Background: People living with transfusion dependent thalassemia have high risk of getting infected by COVID-19. This can be caused by both several factors. Chronic complications of thalassemia also render them more vulnerable to infectious diseases, including COVID-19. However, anecdotal data show...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-01-01
|
| Series: | Hematology Reports |
| Subjects: | |
| Online Access: | https://www.pagepress.org/journals/index.php/hr/article/view/9379 |
| _version_ | 1828046940973039616 |
|---|---|
| author | Tubagus Djumhana Atmakusuma |
| author_facet | Tubagus Djumhana Atmakusuma |
| author_sort | Tubagus Djumhana Atmakusuma |
| collection | DOAJ |
| description | Background: People living with transfusion dependent thalassemia have high risk of getting infected by COVID-19. This can be caused by both several factors. Chronic complications of thalassemia also render them more vulnerable to infectious diseases, including COVID-19. However, anecdotal data shows that Thalassemia patients less incidence of COVID-19 compared to the general population.
Patients and methods: This research used a cross sectional design. The study was conducted at the Division of Haematology and Medical Oncology of the Cipto Mangunkusumo Hospital in Jakarta from May 2020 – August 2021. Total sampling method was used involving all Thalassemia Major patients who had been infected with COVID-19 obtained directly from medical record and through the thalassemia patients-parents foundation
Results: From 10,397 patients with thalassemia, 72 (0.69%) people were infected by COVID-19 and 7 (9.7%) were deceased. Meanwhile, the incidence of COVID-19 in general population of Indonesia was 0.87%, more than in the thalassemia population. This means that thalassemia might provide protection against COVID-19 due to several mechanism.
Conclusion: Indonesia and other countries with high prevalence of thalassemia have lower COVID-19 incidence than countries with low prevalence of thalassemia. Thalassemia might have protective effect against COVID-19. Well designed studies are needed to provide better evidence on the protective effect of thalassemia on COVID-19. |
| first_indexed | 2024-04-10T18:33:14Z |
| format | Article |
| id | doaj.art-7f69696723b04fcd96d535f53fff0bf8 |
| institution | Directory Open Access Journal |
| issn | 2038-8322 2038-8330 |
| language | English |
| last_indexed | 2024-04-10T18:33:14Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Hematology Reports |
| spelling | doaj.art-7f69696723b04fcd96d535f53fff0bf82023-02-02T02:37:43ZengMDPI AGHematology Reports2038-83222038-83302022-01-0113410.4081/hr.2021.9379COVID-19 in patients with transfusion dependent thalassemia in Indonesia: characteristics of the disease and patients, and comparison between epidemiological data for COVID-19 and thalassemia in Indonesia and South-East AsiaTubagus Djumhana Atmakusuma0Rumah Sakit Umum Pusat Nasional Dr. Cipto MangunkusumoBackground: People living with transfusion dependent thalassemia have high risk of getting infected by COVID-19. This can be caused by both several factors. Chronic complications of thalassemia also render them more vulnerable to infectious diseases, including COVID-19. However, anecdotal data shows that Thalassemia patients less incidence of COVID-19 compared to the general population. Patients and methods: This research used a cross sectional design. The study was conducted at the Division of Haematology and Medical Oncology of the Cipto Mangunkusumo Hospital in Jakarta from May 2020 – August 2021. Total sampling method was used involving all Thalassemia Major patients who had been infected with COVID-19 obtained directly from medical record and through the thalassemia patients-parents foundation Results: From 10,397 patients with thalassemia, 72 (0.69%) people were infected by COVID-19 and 7 (9.7%) were deceased. Meanwhile, the incidence of COVID-19 in general population of Indonesia was 0.87%, more than in the thalassemia population. This means that thalassemia might provide protection against COVID-19 due to several mechanism. Conclusion: Indonesia and other countries with high prevalence of thalassemia have lower COVID-19 incidence than countries with low prevalence of thalassemia. Thalassemia might have protective effect against COVID-19. Well designed studies are needed to provide better evidence on the protective effect of thalassemia on COVID-19.https://www.pagepress.org/journals/index.php/hr/article/view/9379COVID-19blood transfusiontransfusion-dependent thalassemiaHbEbeta-thalassemia |
| spellingShingle | Tubagus Djumhana Atmakusuma COVID-19 in patients with transfusion dependent thalassemia in Indonesia: characteristics of the disease and patients, and comparison between epidemiological data for COVID-19 and thalassemia in Indonesia and South-East Asia Hematology Reports COVID-19 blood transfusion transfusion-dependent thalassemia HbE beta-thalassemia |
| title | COVID-19 in patients with transfusion dependent thalassemia in Indonesia: characteristics of the disease and patients, and comparison between epidemiological data for COVID-19 and thalassemia in Indonesia and South-East Asia |
| title_full | COVID-19 in patients with transfusion dependent thalassemia in Indonesia: characteristics of the disease and patients, and comparison between epidemiological data for COVID-19 and thalassemia in Indonesia and South-East Asia |
| title_fullStr | COVID-19 in patients with transfusion dependent thalassemia in Indonesia: characteristics of the disease and patients, and comparison between epidemiological data for COVID-19 and thalassemia in Indonesia and South-East Asia |
| title_full_unstemmed | COVID-19 in patients with transfusion dependent thalassemia in Indonesia: characteristics of the disease and patients, and comparison between epidemiological data for COVID-19 and thalassemia in Indonesia and South-East Asia |
| title_short | COVID-19 in patients with transfusion dependent thalassemia in Indonesia: characteristics of the disease and patients, and comparison between epidemiological data for COVID-19 and thalassemia in Indonesia and South-East Asia |
| title_sort | covid 19 in patients with transfusion dependent thalassemia in indonesia characteristics of the disease and patients and comparison between epidemiological data for covid 19 and thalassemia in indonesia and south east asia |
| topic | COVID-19 blood transfusion transfusion-dependent thalassemia HbE beta-thalassemia |
| url | https://www.pagepress.org/journals/index.php/hr/article/view/9379 |
| work_keys_str_mv | AT tubagusdjumhanaatmakusuma covid19inpatientswithtransfusiondependentthalassemiainindonesiacharacteristicsofthediseaseandpatientsandcomparisonbetweenepidemiologicaldataforcovid19andthalassemiainindonesiaandsoutheastasia |