T Follicular Helper Cells As a New Target for Immunosuppressive Therapies
Over the past decade, antibody-mediated (humoral) rejection has been recognized as a common cause of graft dysfunction after organ transplantation and an important determinant for graft loss. In humoral alloimmunity, T follicular helper (Tfh) cells play a crucial role, because they help naïve B cell...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-11-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2017.01510/full |
| _version_ | 1819117020611870720 |
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| author | Lin Yan Lin Yan Kitty de Leur Kitty de Leur Rudi W. Hendriks Luc J. W. van der Laan Yunying Shi Lanlan Wang Carla C. Baan |
| author_facet | Lin Yan Lin Yan Kitty de Leur Kitty de Leur Rudi W. Hendriks Luc J. W. van der Laan Yunying Shi Lanlan Wang Carla C. Baan |
| author_sort | Lin Yan |
| collection | DOAJ |
| description | Over the past decade, antibody-mediated (humoral) rejection has been recognized as a common cause of graft dysfunction after organ transplantation and an important determinant for graft loss. In humoral alloimmunity, T follicular helper (Tfh) cells play a crucial role, because they help naïve B cells to differentiate into memory B cells and alloantibody-producing plasma cells within germinal centers. In this way, they contribute to the induction of donor-specific antibodies, which are responsible for the humoral immune response to the allograft. In this article, we provide an overview of the current knowledge on the effects of immunosuppressive therapies on Tfh cell development and function, and discuss possible new approaches to influence the activity of Tfh cells. In addition, we discuss the potential use of Tfh cells as a pharmacodynamic biomarker to improve alloimmune-risk stratification and tailoring of immunosuppression to individualize therapy after transplantation. |
| first_indexed | 2024-12-22T05:26:21Z |
| format | Article |
| id | doaj.art-7f6a1a9ed6854f7eb64622ed12e92c24 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-22T05:26:21Z |
| publishDate | 2017-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-7f6a1a9ed6854f7eb64622ed12e92c242022-12-21T18:37:35ZengFrontiers Media S.A.Frontiers in Immunology1664-32242017-11-01810.3389/fimmu.2017.01510304571T Follicular Helper Cells As a New Target for Immunosuppressive TherapiesLin Yan0Lin Yan1Kitty de Leur2Kitty de Leur3Rudi W. Hendriks4Luc J. W. van der Laan5Yunying Shi6Lanlan Wang7Carla C. Baan8Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Internal Medicine, Division of Nephrology and Transplantation, Erasmus MC, University Medical Center, Rotterdam, NetherlandsDepartment of Internal Medicine, Division of Nephrology and Transplantation, Erasmus MC, University Medical Center, Rotterdam, NetherlandsDepartment of Surgery, Erasmus MC, University Medical Center, Rotterdam, NetherlandsDepartment of Pulmonary Medicine, Erasmus MC, University Medical Center, Rotterdam, NetherlandsDepartment of Surgery, Erasmus MC, University Medical Center, Rotterdam, NetherlandsDepartment of Nephrology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Internal Medicine, Division of Nephrology and Transplantation, Erasmus MC, University Medical Center, Rotterdam, NetherlandsOver the past decade, antibody-mediated (humoral) rejection has been recognized as a common cause of graft dysfunction after organ transplantation and an important determinant for graft loss. In humoral alloimmunity, T follicular helper (Tfh) cells play a crucial role, because they help naïve B cells to differentiate into memory B cells and alloantibody-producing plasma cells within germinal centers. In this way, they contribute to the induction of donor-specific antibodies, which are responsible for the humoral immune response to the allograft. In this article, we provide an overview of the current knowledge on the effects of immunosuppressive therapies on Tfh cell development and function, and discuss possible new approaches to influence the activity of Tfh cells. In addition, we discuss the potential use of Tfh cells as a pharmacodynamic biomarker to improve alloimmune-risk stratification and tailoring of immunosuppression to individualize therapy after transplantation.http://journal.frontiersin.org/article/10.3389/fimmu.2017.01510/fullT follicular helper cellsimmunosuppressionhumoral immunitytransplantationallograft rejectiondonor-specific antibodies |
| spellingShingle | Lin Yan Lin Yan Kitty de Leur Kitty de Leur Rudi W. Hendriks Luc J. W. van der Laan Yunying Shi Lanlan Wang Carla C. Baan T Follicular Helper Cells As a New Target for Immunosuppressive Therapies Frontiers in Immunology T follicular helper cells immunosuppression humoral immunity transplantation allograft rejection donor-specific antibodies |
| title | T Follicular Helper Cells As a New Target for Immunosuppressive Therapies |
| title_full | T Follicular Helper Cells As a New Target for Immunosuppressive Therapies |
| title_fullStr | T Follicular Helper Cells As a New Target for Immunosuppressive Therapies |
| title_full_unstemmed | T Follicular Helper Cells As a New Target for Immunosuppressive Therapies |
| title_short | T Follicular Helper Cells As a New Target for Immunosuppressive Therapies |
| title_sort | t follicular helper cells as a new target for immunosuppressive therapies |
| topic | T follicular helper cells immunosuppression humoral immunity transplantation allograft rejection donor-specific antibodies |
| url | http://journal.frontiersin.org/article/10.3389/fimmu.2017.01510/full |
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