Sirtuin 1 in Host Defense during Infection
Sirtuins (SIRTs) are members of the class III histone deacetylase family and epigenetically control multiple target genes to modulate diverse biological responses in cells. Among the SIRTs, SIRT1 is the most well-studied, with a role in the modulation of immune and inflammatory responses following i...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/18/2921 |
| _version_ | 1797490044023341056 |
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| author | Jin Kyung Kim Prashanta Silwal Eun-Kyeong Jo |
| author_facet | Jin Kyung Kim Prashanta Silwal Eun-Kyeong Jo |
| author_sort | Jin Kyung Kim |
| collection | DOAJ |
| description | Sirtuins (SIRTs) are members of the class III histone deacetylase family and epigenetically control multiple target genes to modulate diverse biological responses in cells. Among the SIRTs, SIRT1 is the most well-studied, with a role in the modulation of immune and inflammatory responses following infection. The functions of SIRT1 include orchestrating immune, inflammatory, metabolic, and autophagic responses, all of which are required in establishing and controlling host defenses during infection. In this review, we summarize recent information on the roles of SIRT1 and its regulatory mechanisms during bacterial, viral, and parasitic infections. We also discuss several SIRT1 modulators, as potential antimicrobial treatments. Understanding the function of SIRT1 in balancing immune homeostasis will contribute to the development of new therapeutics for the treatment of infection and inflammatory disease. |
| first_indexed | 2024-03-10T00:25:47Z |
| format | Article |
| id | doaj.art-7f6b985696aa42809405ff56694be0c2 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T00:25:47Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-7f6b985696aa42809405ff56694be0c22023-11-23T15:34:29ZengMDPI AGCells2073-44092022-09-011118292110.3390/cells11182921Sirtuin 1 in Host Defense during InfectionJin Kyung Kim0Prashanta Silwal1Eun-Kyeong Jo2Department of Microbiology, Keimyung University School of Medicine, Daegu 42601, KoreaDepartment of Microbiology, Chungnam National University School of Medicine, Daejeon 35015, KoreaDepartment of Microbiology, Chungnam National University School of Medicine, Daejeon 35015, KoreaSirtuins (SIRTs) are members of the class III histone deacetylase family and epigenetically control multiple target genes to modulate diverse biological responses in cells. Among the SIRTs, SIRT1 is the most well-studied, with a role in the modulation of immune and inflammatory responses following infection. The functions of SIRT1 include orchestrating immune, inflammatory, metabolic, and autophagic responses, all of which are required in establishing and controlling host defenses during infection. In this review, we summarize recent information on the roles of SIRT1 and its regulatory mechanisms during bacterial, viral, and parasitic infections. We also discuss several SIRT1 modulators, as potential antimicrobial treatments. Understanding the function of SIRT1 in balancing immune homeostasis will contribute to the development of new therapeutics for the treatment of infection and inflammatory disease.https://www.mdpi.com/2073-4409/11/18/2921sirtuin 1infectionAMPKbacteriavirusparasite |
| spellingShingle | Jin Kyung Kim Prashanta Silwal Eun-Kyeong Jo Sirtuin 1 in Host Defense during Infection Cells sirtuin 1 infection AMPK bacteria virus parasite |
| title | Sirtuin 1 in Host Defense during Infection |
| title_full | Sirtuin 1 in Host Defense during Infection |
| title_fullStr | Sirtuin 1 in Host Defense during Infection |
| title_full_unstemmed | Sirtuin 1 in Host Defense during Infection |
| title_short | Sirtuin 1 in Host Defense during Infection |
| title_sort | sirtuin 1 in host defense during infection |
| topic | sirtuin 1 infection AMPK bacteria virus parasite |
| url | https://www.mdpi.com/2073-4409/11/18/2921 |
| work_keys_str_mv | AT jinkyungkim sirtuin1inhostdefenseduringinfection AT prashantasilwal sirtuin1inhostdefenseduringinfection AT eunkyeongjo sirtuin1inhostdefenseduringinfection |