Latent Tuberculosis Infection in Potential Renal Transplant Recipients and Live Donors in a Tertiary Level Transplant Center in Nepal
Background: Active tuberculosis in transplant recipients can result from latent infection with Mycobacterium Tuberculosis in the transplant recipients, donor tissue, or de novo post-transplant infection. This study aimed to determine the prevalence of latent tuberculosis infection in potential renal...
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| Format: | Article |
| Language: | English |
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Nobel Medical College Teaching Hospital
2022-12-01
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| Series: | Journal of Nobel Medical College |
| Subjects: | |
| Online Access: | https://www.nepjol.info/index.php/JoNMC/article/view/50452 |
| _version_ | 1797971975565475840 |
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| author | Suresh Maharjan Bikash Khatri Deepa Chemjong Bijay Khatri Dibya Singh Shah |
| author_facet | Suresh Maharjan Bikash Khatri Deepa Chemjong Bijay Khatri Dibya Singh Shah |
| author_sort | Suresh Maharjan |
| collection | DOAJ |
| description | Background: Active tuberculosis in transplant recipients can result from latent infection with Mycobacterium Tuberculosis in the transplant recipients, donor tissue, or de novo post-transplant infection. This study aimed to determine the prevalence of latent tuberculosis infection in potential renal transplant recipients and live donors at a tertiary-level transplant center.
Materials and Methods: This observational study was conducted from July to October 2020 among 72 potential kidney transplant recipients and their potential donors from the Department of Nephrology, Tribhuvan University Teaching Hospital. The biochemical parameters and health behaviors were measured to find the association with latent tuberculosis infection.
Results: The prevalence of latent tuberculosis infection according to Mycobacterium tuberculosis-specific interferon-gamma release assays was 20.8% in potential recipients and 16.6% in potential donors, whereas the prevalence with tuberculin skin test was 9.7% in potential recipients and 33.3% in potential donors. Low levels of hemoglobin, calcium, albumin, vitamin D and history of smoking were associated with the development of latent tuberculosis infection among potential recipients. Alcohol drinking was significantly associated with the development of latent tuberculosis infection among donors.
Conclusion: Potential renal transplant recipients and donors have a significant burden of latent tuberculosis in the pre-transplantation phase. Diagnosis and treatment of latent tuberculosis before transplantation can prevent ominous complications. |
| first_indexed | 2024-04-11T03:41:08Z |
| format | Article |
| id | doaj.art-7f6bcc99f34f4791a7b9c9edafcde01a |
| institution | Directory Open Access Journal |
| issn | 2091-2331 2091-234X |
| language | English |
| last_indexed | 2024-04-11T03:41:08Z |
| publishDate | 2022-12-01 |
| publisher | Nobel Medical College Teaching Hospital |
| record_format | Article |
| series | Journal of Nobel Medical College |
| spelling | doaj.art-7f6bcc99f34f4791a7b9c9edafcde01a2023-01-02T03:41:53ZengNobel Medical College Teaching HospitalJournal of Nobel Medical College2091-23312091-234X2022-12-01112424710.3126/jonmc.v11i2.5045277518Latent Tuberculosis Infection in Potential Renal Transplant Recipients and Live Donors in a Tertiary Level Transplant Center in NepalSuresh Maharjan0https://orcid.org/0000-0002-6318-6354Bikash Khatri1Deepa Chemjong2Bijay Khatri3Dibya Singh Shah4Department of Nephrology, Shahid Dharma bhakta National Transplant Centre, Bhaktapur, NepalDepartment of Nephrology, National Academy of Medical Sciences, Bir Hospital, Kathmandu, NepalDepartment of Medicine, Patan Academy of Health Science, Lalitpur, NepalAcademic and Research Department, Hospital for Children, Eye, ENT, and Rehabilitation Services, Bhaktapur, NepalDepartment of Nephrology, Institute of Medicine, Tribhuvan University Teaching Hospital, Kathmandu, NepalBackground: Active tuberculosis in transplant recipients can result from latent infection with Mycobacterium Tuberculosis in the transplant recipients, donor tissue, or de novo post-transplant infection. This study aimed to determine the prevalence of latent tuberculosis infection in potential renal transplant recipients and live donors at a tertiary-level transplant center. Materials and Methods: This observational study was conducted from July to October 2020 among 72 potential kidney transplant recipients and their potential donors from the Department of Nephrology, Tribhuvan University Teaching Hospital. The biochemical parameters and health behaviors were measured to find the association with latent tuberculosis infection. Results: The prevalence of latent tuberculosis infection according to Mycobacterium tuberculosis-specific interferon-gamma release assays was 20.8% in potential recipients and 16.6% in potential donors, whereas the prevalence with tuberculin skin test was 9.7% in potential recipients and 33.3% in potential donors. Low levels of hemoglobin, calcium, albumin, vitamin D and history of smoking were associated with the development of latent tuberculosis infection among potential recipients. Alcohol drinking was significantly associated with the development of latent tuberculosis infection among donors. Conclusion: Potential renal transplant recipients and donors have a significant burden of latent tuberculosis in the pre-transplantation phase. Diagnosis and treatment of latent tuberculosis before transplantation can prevent ominous complications.https://www.nepjol.info/index.php/JoNMC/article/view/50452kidney transplantationlatent infectionmycobacterium tuberculosis |
| spellingShingle | Suresh Maharjan Bikash Khatri Deepa Chemjong Bijay Khatri Dibya Singh Shah Latent Tuberculosis Infection in Potential Renal Transplant Recipients and Live Donors in a Tertiary Level Transplant Center in Nepal Journal of Nobel Medical College kidney transplantation latent infection mycobacterium tuberculosis |
| title | Latent Tuberculosis Infection in Potential Renal Transplant Recipients and Live Donors in a Tertiary Level Transplant Center in Nepal |
| title_full | Latent Tuberculosis Infection in Potential Renal Transplant Recipients and Live Donors in a Tertiary Level Transplant Center in Nepal |
| title_fullStr | Latent Tuberculosis Infection in Potential Renal Transplant Recipients and Live Donors in a Tertiary Level Transplant Center in Nepal |
| title_full_unstemmed | Latent Tuberculosis Infection in Potential Renal Transplant Recipients and Live Donors in a Tertiary Level Transplant Center in Nepal |
| title_short | Latent Tuberculosis Infection in Potential Renal Transplant Recipients and Live Donors in a Tertiary Level Transplant Center in Nepal |
| title_sort | latent tuberculosis infection in potential renal transplant recipients and live donors in a tertiary level transplant center in nepal |
| topic | kidney transplantation latent infection mycobacterium tuberculosis |
| url | https://www.nepjol.info/index.php/JoNMC/article/view/50452 |
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