Antifungal activity of Co(II) and Cu(II) complexes containing 1,3-bis(benzotriazol-1-yl)-propan-2-ol on the growth and virulence traits of fluconazole-resistant Candida species: synthesis, DFT calculations, and biological activity

Antifungal activity of Co(II) and Cu(II) complexes containing 1,3-bis(benzotriazol-1-yl)-propan-2-ol on the growth and virulence traits of fluconazole-resistant Candida species: synthesis, DFT calculations, and biological activity

Abstract Relevant virulence traits in Candida spp. are associated with dimorphic change and biofilm formation, which became an important target to reduce antifungal resistance. In this work, Co(II) complexes containing a benzotriazole derivative ligand showed a promising capacity of reducing these v...

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Bibliographic Details
Main Authors: Ricardo A. Murcia-Galán, Sandra M. Durán, Sandra M. Leal-Pinto, Martha V. Roa-Cordero, Jose D. Vargas, Laura V. Herrera, Alvaro Muñoz-Castro, Desmond MacLeod-Carey, Tonny W. Naranjo, Peter L. Rodríguez-Kessler, John J. Hurtado
Format: Article
Language:English
Published: BMC 2023-10-01
Series:BMC Chemistry
Subjects:
Benzotriazole ligand
Cobalt(II) and copper(II) complexes
Antifungal activity
Antibiofilm agents
Candida species
Virulence traits
Online Access:https://doi.org/10.1186/s13065-023-01037-7

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