Prediction of Tumor Recurrence in Patients with Non-Gastric Gastrointestinal Stromal Tumors Following Resection according to the Modified National Institutes of Health Criteria
Background/AimsFew studies have investigated the prognosis of non-gastric gastrointestinal stromal tumors (GISTs) under the modified National Institutes of Health (NIH) consensus criteria in Korea. This study aims to clarify the clinical usefulness of the modified NIH criteria for risk stratificatio...
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| Format: | Article |
| Language: | English |
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Korean Association for the Study of Intestinal Diseases
2014-07-01
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| Series: | Intestinal Research |
| Subjects: | |
| Online Access: | http://www.irjournal.org/upload/pdf/ir-12-229.pdf |
| _version_ | 1818317369480577024 |
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| author | Seung Hyeon Jang Ji Eun Kwon Jee Hyun Kim June Young Lee Sang Gyun Kim Joo Sung Kim Hyun Chae Jung Jong Pil Im |
| author_facet | Seung Hyeon Jang Ji Eun Kwon Jee Hyun Kim June Young Lee Sang Gyun Kim Joo Sung Kim Hyun Chae Jung Jong Pil Im |
| author_sort | Seung Hyeon Jang |
| collection | DOAJ |
| description | Background/AimsFew studies have investigated the prognosis of non-gastric gastrointestinal stromal tumors (GISTs) under the modified National Institutes of Health (NIH) consensus criteria in Korea. This study aims to clarify the clinical usefulness of the modified NIH criteria for risk stratification.MethodsFrom January 2000 through October 2012, 88 patients who underwent curative resection for primary GISTs were included in this study. The enrolled patients were stratified to predict recurrence by the original NIH criteria and modified NIH criteria.ResultsIn all, 88 patients had non-gastric GISTs, including 82 and 6 patients with GISTs of the small intestine and colorectum, respectively. The mean age was 57.3±13.0 years, and the median follow-up duration was 3.40 years (range, 0.02-12.76 years). All patients who were placed in the intermediate-risk category according to the original NIH criteria were reclassified into the high-risk category according to the modified NIH criteria. Therefore, the proportion of cases in the intermediate-risk category declined to 0.0% from 25.0% (22/88), and the proportion of cases in the high-risk category increased to 43.2% (38/88) from 18.2% (16/88) under the modified NIH criteria. Among the 22 reclassified patients, 6 (27.3%) suffered a recurrence during the observational period, and the recurrence rate of high-risk category patients was 36.8% (14/38).ConclusionsPatients in the high-risk category according to the modified NIH criteria had a high GIST recurrence rate. Therefore, the modified NIH criteria are clinically useful in selecting patients who need imatinib adjuvant chemotherapy after curative surgical resection. |
| first_indexed | 2024-12-13T09:36:14Z |
| format | Article |
| id | doaj.art-7f6ea3b463384bd8b88f33395cd430f0 |
| institution | Directory Open Access Journal |
| issn | 1598-9100 2288-1956 |
| language | English |
| last_indexed | 2024-12-13T09:36:14Z |
| publishDate | 2014-07-01 |
| publisher | Korean Association for the Study of Intestinal Diseases |
| record_format | Article |
| series | Intestinal Research |
| spelling | doaj.art-7f6ea3b463384bd8b88f33395cd430f02022-12-21T23:52:21ZengKorean Association for the Study of Intestinal DiseasesIntestinal Research1598-91002288-19562014-07-0112322923510.5217/ir.2014.12.3.22925Prediction of Tumor Recurrence in Patients with Non-Gastric Gastrointestinal Stromal Tumors Following Resection according to the Modified National Institutes of Health CriteriaSeung Hyeon Jang0Ji Eun Kwon1Jee Hyun Kim2June Young Lee3Sang Gyun Kim4Joo Sung Kim5Hyun Chae Jung6Jong Pil Im7Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.Background/AimsFew studies have investigated the prognosis of non-gastric gastrointestinal stromal tumors (GISTs) under the modified National Institutes of Health (NIH) consensus criteria in Korea. This study aims to clarify the clinical usefulness of the modified NIH criteria for risk stratification.MethodsFrom January 2000 through October 2012, 88 patients who underwent curative resection for primary GISTs were included in this study. The enrolled patients were stratified to predict recurrence by the original NIH criteria and modified NIH criteria.ResultsIn all, 88 patients had non-gastric GISTs, including 82 and 6 patients with GISTs of the small intestine and colorectum, respectively. The mean age was 57.3±13.0 years, and the median follow-up duration was 3.40 years (range, 0.02-12.76 years). All patients who were placed in the intermediate-risk category according to the original NIH criteria were reclassified into the high-risk category according to the modified NIH criteria. Therefore, the proportion of cases in the intermediate-risk category declined to 0.0% from 25.0% (22/88), and the proportion of cases in the high-risk category increased to 43.2% (38/88) from 18.2% (16/88) under the modified NIH criteria. Among the 22 reclassified patients, 6 (27.3%) suffered a recurrence during the observational period, and the recurrence rate of high-risk category patients was 36.8% (14/38).ConclusionsPatients in the high-risk category according to the modified NIH criteria had a high GIST recurrence rate. Therefore, the modified NIH criteria are clinically useful in selecting patients who need imatinib adjuvant chemotherapy after curative surgical resection.http://www.irjournal.org/upload/pdf/ir-12-229.pdfGastrointestinal stromal tumorsPrognosisRecurrenceNational Institutes of Health (U.S.) |
| spellingShingle | Seung Hyeon Jang Ji Eun Kwon Jee Hyun Kim June Young Lee Sang Gyun Kim Joo Sung Kim Hyun Chae Jung Jong Pil Im Prediction of Tumor Recurrence in Patients with Non-Gastric Gastrointestinal Stromal Tumors Following Resection according to the Modified National Institutes of Health Criteria Intestinal Research Gastrointestinal stromal tumors Prognosis Recurrence National Institutes of Health (U.S.) |
| title | Prediction of Tumor Recurrence in Patients with Non-Gastric Gastrointestinal Stromal Tumors Following Resection according to the Modified National Institutes of Health Criteria |
| title_full | Prediction of Tumor Recurrence in Patients with Non-Gastric Gastrointestinal Stromal Tumors Following Resection according to the Modified National Institutes of Health Criteria |
| title_fullStr | Prediction of Tumor Recurrence in Patients with Non-Gastric Gastrointestinal Stromal Tumors Following Resection according to the Modified National Institutes of Health Criteria |
| title_full_unstemmed | Prediction of Tumor Recurrence in Patients with Non-Gastric Gastrointestinal Stromal Tumors Following Resection according to the Modified National Institutes of Health Criteria |
| title_short | Prediction of Tumor Recurrence in Patients with Non-Gastric Gastrointestinal Stromal Tumors Following Resection according to the Modified National Institutes of Health Criteria |
| title_sort | prediction of tumor recurrence in patients with non gastric gastrointestinal stromal tumors following resection according to the modified national institutes of health criteria |
| topic | Gastrointestinal stromal tumors Prognosis Recurrence National Institutes of Health (U.S.) |
| url | http://www.irjournal.org/upload/pdf/ir-12-229.pdf |
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