Sortilin participates in light-dependent photoreceptor degeneration in vivo.

Sortilin participates in light-dependent photoreceptor degeneration in vivo.

Both proNGF and the neurotrophin receptor p75 (p75(NTR)) are known to regulate photoreceptor cell death caused by exposure of albino mice to intense illumination. ProNGF-induced apoptosis requires the participation of sortilin as a necessary p75(NTR) co-receptor, suggesting that sortilin may partici...

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Bibliographic Details
Main Authors: Ana M Santos, Noelia López-Sánchez, David Martín-Oliva, Pedro de la Villa, Miguel A Cuadros, José M Frade
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3338683?pdf=render

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