Association of constipation with increased risk of hypertension and cardiovascular events in elderly Australian patients
Abstract The association between constipation and cardiovascular risk is unclear. This population-level matched cohort study compared the association of constipation with hypertension and incident cardiovascular events in 541,172 hospitalized patients aged ≥ 60 years. For each constipation admission...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-07-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-38068-y |
| _version_ | 1797784703103664128 |
|---|---|
| author | Courtney P. Judkins Yutang Wang Maria Jelinic Alex Bobik Antony Vinh Christopher G. Sobey Grant R. Drummond |
| author_facet | Courtney P. Judkins Yutang Wang Maria Jelinic Alex Bobik Antony Vinh Christopher G. Sobey Grant R. Drummond |
| author_sort | Courtney P. Judkins |
| collection | DOAJ |
| description | Abstract The association between constipation and cardiovascular risk is unclear. This population-level matched cohort study compared the association of constipation with hypertension and incident cardiovascular events in 541,172 hospitalized patients aged ≥ 60 years. For each constipation admission, one exact age-matched non-constipated admission was randomly selected from all hospitalizations within 2 weeks to form the comparison cohort. The association of constipation with hypertension and cardiovascular events (myocardial infarction, angina, stroke and transient ischemic attack) were analysed using a series of binary logistic regressions adjusting for age, sex, cardiovascular risk factors, gastrointestinal disorders and sociological factors. Patients with constipation had a higher multivariate-adjusted risk for hypertension (odds ratio [OR], 1.96; 95% confidence interval [CI] 1.94–1.99; P < 0.001). Compared to patients with neither constipation nor hypertension, there was a higher multivariate-adjusted risk for cardiovascular events in patients with constipation alone (OR, 1.58; 95% CI 1.55–1.61; P < 0.001) or hypertension alone (OR, 6.12; 95% CI 5.99–6.26; P < 0.001). In patients with both constipation and hypertension, the risk for all cardiovascular events appeared to be additive (OR, 6.53; 95% CI 6.40–6.66; P < 0.001). In conclusion, among hospital patients aged 60 years or older, constipation is linked to an increased risk of hypertension and cardiovascular events. These findings suggest that interventions to address constipation may reduce cardiovascular risk in elderly patients. |
| first_indexed | 2024-03-13T00:43:40Z |
| format | Article |
| id | doaj.art-7f71f54c97194ba08c727ed9d22adb67 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-13T00:43:40Z |
| publishDate | 2023-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-7f71f54c97194ba08c727ed9d22adb672023-07-09T11:11:07ZengNature PortfolioScientific Reports2045-23222023-07-011311910.1038/s41598-023-38068-yAssociation of constipation with increased risk of hypertension and cardiovascular events in elderly Australian patientsCourtney P. Judkins0Yutang Wang1Maria Jelinic2Alex Bobik3Antony Vinh4Christopher G. Sobey5Grant R. Drummond6Centre for Cardiovascular Biology and Disease Research and Department of Microbiology, Anatomy, Physiology & Pharmacology, School of Agriculture, Biomedicine & Environment, La Trobe UniversityDiscipline of Life Science, Institute of Innovation, Science and Sustainability, Federation University AustraliaCentre for Cardiovascular Biology and Disease Research and Department of Microbiology, Anatomy, Physiology & Pharmacology, School of Agriculture, Biomedicine & Environment, La Trobe UniversityCentre for Cardiovascular Biology and Disease Research and Department of Microbiology, Anatomy, Physiology & Pharmacology, School of Agriculture, Biomedicine & Environment, La Trobe UniversityCentre for Cardiovascular Biology and Disease Research and Department of Microbiology, Anatomy, Physiology & Pharmacology, School of Agriculture, Biomedicine & Environment, La Trobe UniversityCentre for Cardiovascular Biology and Disease Research and Department of Microbiology, Anatomy, Physiology & Pharmacology, School of Agriculture, Biomedicine & Environment, La Trobe UniversityCentre for Cardiovascular Biology and Disease Research and Department of Microbiology, Anatomy, Physiology & Pharmacology, School of Agriculture, Biomedicine & Environment, La Trobe UniversityAbstract The association between constipation and cardiovascular risk is unclear. This population-level matched cohort study compared the association of constipation with hypertension and incident cardiovascular events in 541,172 hospitalized patients aged ≥ 60 years. For each constipation admission, one exact age-matched non-constipated admission was randomly selected from all hospitalizations within 2 weeks to form the comparison cohort. The association of constipation with hypertension and cardiovascular events (myocardial infarction, angina, stroke and transient ischemic attack) were analysed using a series of binary logistic regressions adjusting for age, sex, cardiovascular risk factors, gastrointestinal disorders and sociological factors. Patients with constipation had a higher multivariate-adjusted risk for hypertension (odds ratio [OR], 1.96; 95% confidence interval [CI] 1.94–1.99; P < 0.001). Compared to patients with neither constipation nor hypertension, there was a higher multivariate-adjusted risk for cardiovascular events in patients with constipation alone (OR, 1.58; 95% CI 1.55–1.61; P < 0.001) or hypertension alone (OR, 6.12; 95% CI 5.99–6.26; P < 0.001). In patients with both constipation and hypertension, the risk for all cardiovascular events appeared to be additive (OR, 6.53; 95% CI 6.40–6.66; P < 0.001). In conclusion, among hospital patients aged 60 years or older, constipation is linked to an increased risk of hypertension and cardiovascular events. These findings suggest that interventions to address constipation may reduce cardiovascular risk in elderly patients.https://doi.org/10.1038/s41598-023-38068-y |
| spellingShingle | Courtney P. Judkins Yutang Wang Maria Jelinic Alex Bobik Antony Vinh Christopher G. Sobey Grant R. Drummond Association of constipation with increased risk of hypertension and cardiovascular events in elderly Australian patients Scientific Reports |
| title | Association of constipation with increased risk of hypertension and cardiovascular events in elderly Australian patients |
| title_full | Association of constipation with increased risk of hypertension and cardiovascular events in elderly Australian patients |
| title_fullStr | Association of constipation with increased risk of hypertension and cardiovascular events in elderly Australian patients |
| title_full_unstemmed | Association of constipation with increased risk of hypertension and cardiovascular events in elderly Australian patients |
| title_short | Association of constipation with increased risk of hypertension and cardiovascular events in elderly Australian patients |
| title_sort | association of constipation with increased risk of hypertension and cardiovascular events in elderly australian patients |
| url | https://doi.org/10.1038/s41598-023-38068-y |
| work_keys_str_mv | AT courtneypjudkins associationofconstipationwithincreasedriskofhypertensionandcardiovasculareventsinelderlyaustralianpatients AT yutangwang associationofconstipationwithincreasedriskofhypertensionandcardiovasculareventsinelderlyaustralianpatients AT mariajelinic associationofconstipationwithincreasedriskofhypertensionandcardiovasculareventsinelderlyaustralianpatients AT alexbobik associationofconstipationwithincreasedriskofhypertensionandcardiovasculareventsinelderlyaustralianpatients AT antonyvinh associationofconstipationwithincreasedriskofhypertensionandcardiovasculareventsinelderlyaustralianpatients AT christophergsobey associationofconstipationwithincreasedriskofhypertensionandcardiovasculareventsinelderlyaustralianpatients AT grantrdrummond associationofconstipationwithincreasedriskofhypertensionandcardiovasculareventsinelderlyaustralianpatients |