From seeds to survival rates: investigating Linum usitatissimum’s potential against ovarian cancer through network pharmacology
Ovarian cancer is a malignant tumor that primarily forms in the ovaries. It often goes undetected until it has spread to the pelvis and abdomen, making it more challenging to treat and often fatal. Historically, natural products and their structural analogues have played a pivotal role in pharmacoth...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1285258/full |
| _version_ | 1827779618335096832 |
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| author | Mohammed Monirul Islam Nagaraja Sreeharsha Nagaraja Sreeharsha Fahad M. Alshabrmi Afzal Haq Asif Bandar Aldhubiab Md Khalid Anwer Rajendiran Krishnasamy Abdur Rehman |
| author_facet | Mohammed Monirul Islam Nagaraja Sreeharsha Nagaraja Sreeharsha Fahad M. Alshabrmi Afzal Haq Asif Bandar Aldhubiab Md Khalid Anwer Rajendiran Krishnasamy Abdur Rehman |
| author_sort | Mohammed Monirul Islam |
| collection | DOAJ |
| description | Ovarian cancer is a malignant tumor that primarily forms in the ovaries. It often goes undetected until it has spread to the pelvis and abdomen, making it more challenging to treat and often fatal. Historically, natural products and their structural analogues have played a pivotal role in pharmacotherapy, especially for cancer. Numerous studies have demonstrated the therapeutic potential of Linum usitatissimum against ovarian cancer, but the specific molecular mechanisms remain elusive. This study combines data mining, network pharmacology, and molecular docking analysis to pioneer an innovative approach for ovarian cancer treatment by identifying potent phytochemicals. Findings of current study revealed that Apigenin, Vitamin E, Palmitic acid, Riboflavin, Isolariciresinol, 5-Dehydro-avenasterol, Cholesterol, Pantothenic acid, Nicotinic acid, Campesterol, Beta-Sitosterol, Stigmasterol, Daucosterol, and Vitexin suppress tumor growth by influencing AKT1, JUN, EGFR, and VEGFA. Kaplan–Meier survival analysis spotlighted AKT1, JUN, EGFR, and VEGFA as potential diagnostic and prognostic biomarkers for ovarian cancer. However, it is imperative to conduct in vivo and in vitro examinations to ascertain the pharmacokinetics and biosafety profiles, bolstering the candidacy of L. usitatissimum in ovarian cancer therapeutics. |
| first_indexed | 2024-03-11T14:51:56Z |
| format | Article |
| id | doaj.art-7f72fb0383da491a948cb9652434cfe1 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-11T14:51:56Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-7f72fb0383da491a948cb9652434cfe12023-10-30T09:12:47ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-10-011410.3389/fphar.2023.12852581285258From seeds to survival rates: investigating Linum usitatissimum’s potential against ovarian cancer through network pharmacologyMohammed Monirul Islam0Nagaraja Sreeharsha1Nagaraja Sreeharsha2Fahad M. Alshabrmi3Afzal Haq Asif4Bandar Aldhubiab5Md Khalid Anwer6Rajendiran Krishnasamy7Abdur Rehman8Department of Biomedical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi ArabiaDepartment of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi ArabiaDepartment of Pharmaceutics, Vidya Siri College of Pharmacy, Bangalore, IndiaDepartment of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi ArabiaDepartment of Pharmacy Practice, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi ArabiaDepartment of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi ArabiaDepartment of Pharmacognosy, Vidya Siri College of Pharmacy, Bangalore, IndiaCenter of Bioinformatics, College of Life Sciences, Northwest A&F University, Yangling, ChinaOvarian cancer is a malignant tumor that primarily forms in the ovaries. It often goes undetected until it has spread to the pelvis and abdomen, making it more challenging to treat and often fatal. Historically, natural products and their structural analogues have played a pivotal role in pharmacotherapy, especially for cancer. Numerous studies have demonstrated the therapeutic potential of Linum usitatissimum against ovarian cancer, but the specific molecular mechanisms remain elusive. This study combines data mining, network pharmacology, and molecular docking analysis to pioneer an innovative approach for ovarian cancer treatment by identifying potent phytochemicals. Findings of current study revealed that Apigenin, Vitamin E, Palmitic acid, Riboflavin, Isolariciresinol, 5-Dehydro-avenasterol, Cholesterol, Pantothenic acid, Nicotinic acid, Campesterol, Beta-Sitosterol, Stigmasterol, Daucosterol, and Vitexin suppress tumor growth by influencing AKT1, JUN, EGFR, and VEGFA. Kaplan–Meier survival analysis spotlighted AKT1, JUN, EGFR, and VEGFA as potential diagnostic and prognostic biomarkers for ovarian cancer. However, it is imperative to conduct in vivo and in vitro examinations to ascertain the pharmacokinetics and biosafety profiles, bolstering the candidacy of L. usitatissimum in ovarian cancer therapeutics.https://www.frontiersin.org/articles/10.3389/fphar.2023.1285258/fullovarian cancerLinum usitatissimum’snetwork pharmacologymolecular dockingmolecular dynamic simulation |
| spellingShingle | Mohammed Monirul Islam Nagaraja Sreeharsha Nagaraja Sreeharsha Fahad M. Alshabrmi Afzal Haq Asif Bandar Aldhubiab Md Khalid Anwer Rajendiran Krishnasamy Abdur Rehman From seeds to survival rates: investigating Linum usitatissimum’s potential against ovarian cancer through network pharmacology Frontiers in Pharmacology ovarian cancer Linum usitatissimum’s network pharmacology molecular docking molecular dynamic simulation |
| title | From seeds to survival rates: investigating Linum usitatissimum’s potential against ovarian cancer through network pharmacology |
| title_full | From seeds to survival rates: investigating Linum usitatissimum’s potential against ovarian cancer through network pharmacology |
| title_fullStr | From seeds to survival rates: investigating Linum usitatissimum’s potential against ovarian cancer through network pharmacology |
| title_full_unstemmed | From seeds to survival rates: investigating Linum usitatissimum’s potential against ovarian cancer through network pharmacology |
| title_short | From seeds to survival rates: investigating Linum usitatissimum’s potential against ovarian cancer through network pharmacology |
| title_sort | from seeds to survival rates investigating linum usitatissimum s potential against ovarian cancer through network pharmacology |
| topic | ovarian cancer Linum usitatissimum’s network pharmacology molecular docking molecular dynamic simulation |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1285258/full |
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