Retinal vascular density in CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy)
Background and objective Retinal vascular density (VD) measured using optical coherence tomography with angiography (OCTA) has been suggested as a potential marker of intracerebral vascular changes in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2023-05-01
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| Series: | BMJ Neurology Open |
| Online Access: | https://neurologyopen.bmj.com/content/5/1/e000417.full |
| _version_ | 1797741134002257920 |
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| author | Michel Paques Ramin Tadayoni Dominique Hervé Eric Jouvent Hugues Chabriat Valérie Krivosic Cedric Duliére Abbas Taleb Nathalie Gastellier Jessica Lebenberg |
| author_facet | Michel Paques Ramin Tadayoni Dominique Hervé Eric Jouvent Hugues Chabriat Valérie Krivosic Cedric Duliére Abbas Taleb Nathalie Gastellier Jessica Lebenberg |
| author_sort | Michel Paques |
| collection | DOAJ |
| description | Background and objective Retinal vascular density (VD) measured using optical coherence tomography with angiography (OCTA) has been suggested as a potential marker of intracerebral vascular changes in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL). We aimed to determine whether VD is related to the clinical and imaging manifestations of the disease.Methods OCTA was performed in 104 CADASIL patients (parallel to their clinical and imaging assessment) and in 83 healthy individuals.Results A significant reduction of VD related to age was detected in patients and controls in the superficial and deep vascular plexus of the whole foveal or parafoveal retinal area (p<0.0001). After adjustment for age, these parameters were found significantly lower in patients than in controls (p<0.03). Multivariable analysis did not show any association between retinal VD and history of stroke, modified Rankin Scale or Mini-Mental Status Examination scores. No significant association was found with MRI lesions either .Conclusion In CADASIL, retinal VD is decreased early and progresses with ageing but does not appear related to the severity of clinical or imaging manifestations. |
| first_indexed | 2024-03-12T14:22:29Z |
| format | Article |
| id | doaj.art-7f73d667e62c4b9f9e4153c4fbde6258 |
| institution | Directory Open Access Journal |
| issn | 2632-6140 |
| language | English |
| last_indexed | 2024-03-12T14:22:29Z |
| publishDate | 2023-05-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Neurology Open |
| spelling | doaj.art-7f73d667e62c4b9f9e4153c4fbde62582023-08-18T15:55:07ZengBMJ Publishing GroupBMJ Neurology Open2632-61402023-05-015110.1136/bmjno-2023-000417Retinal vascular density in CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy)Michel Paques0Ramin Tadayoni1Dominique Hervé2Eric Jouvent3Hugues Chabriat4Valérie Krivosic5Cedric Duliére6Abbas Taleb7Nathalie Gastellier8Jessica Lebenberg9CIC Ophtalmology - 15-20 Hospital, INSERM, Paris, FranceOphtalmology, APHP Hopital Lariboiisiere, Paris, FranceCNVT - CERVCO and Neurology, Hopital Lariboisiere, APHP, Paris, FranceU1141, INSERM and Université Paris-Cité, Paris, FranceCNVT - CERVCO and Neurology, Hopital Lariboisiere, APHP, Paris, FranceOphtalmology, APHP Hopital Lariboiisiere, Paris, FranceOphtalmology, APHP Hopital Lariboiisiere, Paris, FranceCNVT - CERVCO and Neurology, Hopital Lariboisiere, APHP, Paris, FranceCNVT - CERVCO and Neurology, Hopital Lariboisiere, APHP, Paris, FranceCNVT - CERVCO and Neurology, Hopital Lariboisiere, APHP, Paris, FranceBackground and objective Retinal vascular density (VD) measured using optical coherence tomography with angiography (OCTA) has been suggested as a potential marker of intracerebral vascular changes in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL). We aimed to determine whether VD is related to the clinical and imaging manifestations of the disease.Methods OCTA was performed in 104 CADASIL patients (parallel to their clinical and imaging assessment) and in 83 healthy individuals.Results A significant reduction of VD related to age was detected in patients and controls in the superficial and deep vascular plexus of the whole foveal or parafoveal retinal area (p<0.0001). After adjustment for age, these parameters were found significantly lower in patients than in controls (p<0.03). Multivariable analysis did not show any association between retinal VD and history of stroke, modified Rankin Scale or Mini-Mental Status Examination scores. No significant association was found with MRI lesions either .Conclusion In CADASIL, retinal VD is decreased early and progresses with ageing but does not appear related to the severity of clinical or imaging manifestations.https://neurologyopen.bmj.com/content/5/1/e000417.full |
| spellingShingle | Michel Paques Ramin Tadayoni Dominique Hervé Eric Jouvent Hugues Chabriat Valérie Krivosic Cedric Duliére Abbas Taleb Nathalie Gastellier Jessica Lebenberg Retinal vascular density in CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) BMJ Neurology Open |
| title | Retinal vascular density in CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) |
| title_full | Retinal vascular density in CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) |
| title_fullStr | Retinal vascular density in CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) |
| title_full_unstemmed | Retinal vascular density in CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) |
| title_short | Retinal vascular density in CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) |
| title_sort | retinal vascular density in cadasil cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy |
| url | https://neurologyopen.bmj.com/content/5/1/e000417.full |
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