Improved Synthesis and Crystal Structure of Dalcetrapib

Improved Synthesis and Crystal Structure of Dalcetrapib

An improved synthesis of the Cholesteryl Ester Transfer Protein inhibitor dalcetrapib is reported. The precursor disulfide was reduced (a) by Mg/MeOH or (b) by EtSH/DBU/THF. The resulting thiol was acylated (a) by a known procedure or (b) in a one-pot process. Impurities were removed (a) by dithioth...

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Bibliographic Details
Main Authors:	Frank Richter, Sven Nerdinger, Herwig Schottenberger, Volker Kahlenberg, Gerhard Laus
Format:	Article
Language:	English
Published:	MDPI AG 2012-10-01
Series:	Crystals
Subjects:	CETP inhibitor dalcetrapib disulfide thioester
Online Access:	http://www.mdpi.com/2073-4352/2/4/1455

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