TPPU Pre-Treatment Rescues Dendritic Spine Loss and Alleviates Depressive Behaviours during the Latent Period in the Lithium Chloride-Pilocarpine-Induced Status Epilepticus Rat Model

TPPU Pre-Treatment Rescues Dendritic Spine Loss and Alleviates Depressive Behaviours during the Latent Period in the Lithium Chloride-Pilocarpine-Induced Status Epilepticus Rat Model

Epileptogenesis may be responsible for both of recurrent seizures and comorbid depression in epilepsy. Disease-modifying treatments targeting the latent period before spontaneous recurrent seizures may contribute to the remission of seizures and comorbid depression. We hypothesized that pre-treatmen...

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Bibliographic Details
Main Authors: Weifeng Peng, Yijun Shen, Qiang Wang, Jing Ding, Xin Wang
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Brain Sciences
Subjects:
epileptogenesis
depression
comorbidity
soluble epoxide hydrolase
inflammation
dendritic spine
Online Access:https://www.mdpi.com/2076-3425/11/11/1465

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