The Effect of Moringa leaf extract supplementation on IL-6 protein expression in endurance-training-induced inflammation of Wistar rat muscles
Overtraining can cause muscle inflammation. Untreated inflammation might cause permanent damage. Traumas can create dysfunction physically and functionally. One study demonstrated that moringa contained a high content of micro- and macronutrients, such as protein, energy, and vitamins, and had sever...
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| Format: | Article |
| Language: | English |
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Universitas Pendidikan Indonesia
2023-05-01
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| Series: | Jurnal Pendidikan Jasmani dan Olahraga |
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| Online Access: | https://ejournal.upi.edu/index.php/penjas/article/view/56199 |
| _version_ | 1797817203821641728 |
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| author | Afianti Sulastri Natasya Natasya Muhammad Naufal Abdurahman Pipit Pitriani Hamidie Ronald Daniel Ray |
| author_facet | Afianti Sulastri Natasya Natasya Muhammad Naufal Abdurahman Pipit Pitriani Hamidie Ronald Daniel Ray |
| author_sort | Afianti Sulastri |
| collection | DOAJ |
| description | Overtraining can cause muscle inflammation. Untreated inflammation might cause permanent damage. Traumas can create dysfunction physically and functionally. One study demonstrated that moringa contained a high content of micro- and macronutrients, such as protein, energy, and vitamins, and had several therapeutic effects. This study aimed to evaluate the effects of moringa in inflammation reduction, due to endurance training (eTR), on skeletal muscle. The sample consisted of 12 adults male Wistar rats separated into three groups, including two exercise groups and one non-exercise group. One of the exercise groups was given moringa leaf extract (eTMO) at a dose of 0.02 mg/kg/day of body weight, which was suspended in 0.5% Na-CMC, taken orally for 28 days. The exercise rat groups were trained on a treadmill for 30 minutes every day for 28 days. Western blotting (WB) was utilized for the detection of IL-6 protein expression. These findings demonstrated that the treatment using M. oleifera leaf extract combined with endurance exercise reduced the expression of the protein IL-6 subunit in the gastrocnemius (Gas) muscles. This data revealed that the combination of Moringa oleifera and exercise could potentially lower IL-6 levels in skeletal muscle. |
| first_indexed | 2024-03-13T08:50:15Z |
| format | Article |
| id | doaj.art-7f789a590e814d80b694fb56d0ad9d7d |
| institution | Directory Open Access Journal |
| issn | 2085-6180 2580-071X |
| language | English |
| last_indexed | 2024-03-13T08:50:15Z |
| publishDate | 2023-05-01 |
| publisher | Universitas Pendidikan Indonesia |
| record_format | Article |
| series | Jurnal Pendidikan Jasmani dan Olahraga |
| spelling | doaj.art-7f789a590e814d80b694fb56d0ad9d7d2023-05-29T14:45:00ZengUniversitas Pendidikan IndonesiaJurnal Pendidikan Jasmani dan Olahraga2085-61802580-071X2023-05-018113313910.17509/jpjo.v8i1.5619921542The Effect of Moringa leaf extract supplementation on IL-6 protein expression in endurance-training-induced inflammation of Wistar rat musclesAfianti Sulastri0Natasya Natasya1Muhammad Naufal Abdurahman2Pipit Pitriani3Hamidie Ronald Daniel Ray4Department of Nursing, Faculty of Sport and Health Education, Universitas Pendidikan Indonesia, Bandung, IndonesiaDepartment of Nursing, Faculty of Sport and Health Education, Universitas Pendidikan Indonesia, Bandung, IndonesiaDepartment of Sport Education, School of Postgraduate Program, Universitas Pendidikan Indonesia, Bandung, IndonesiaSport Coaching Study Program, Faculty of Sport and Health Education, Universitas Pendidikan Indonesia, Bandung, IndonesiaSport Science Study Program, Faculty of Sport and Health Education, Universitas Pendidikan Indonesia, Bandung, IndonesiaOvertraining can cause muscle inflammation. Untreated inflammation might cause permanent damage. Traumas can create dysfunction physically and functionally. One study demonstrated that moringa contained a high content of micro- and macronutrients, such as protein, energy, and vitamins, and had several therapeutic effects. This study aimed to evaluate the effects of moringa in inflammation reduction, due to endurance training (eTR), on skeletal muscle. The sample consisted of 12 adults male Wistar rats separated into three groups, including two exercise groups and one non-exercise group. One of the exercise groups was given moringa leaf extract (eTMO) at a dose of 0.02 mg/kg/day of body weight, which was suspended in 0.5% Na-CMC, taken orally for 28 days. The exercise rat groups were trained on a treadmill for 30 minutes every day for 28 days. Western blotting (WB) was utilized for the detection of IL-6 protein expression. These findings demonstrated that the treatment using M. oleifera leaf extract combined with endurance exercise reduced the expression of the protein IL-6 subunit in the gastrocnemius (Gas) muscles. This data revealed that the combination of Moringa oleifera and exercise could potentially lower IL-6 levels in skeletal muscle.https://ejournal.upi.edu/index.php/penjas/article/view/56199anti-inflammatory, endurance training, il-6, moringa oleifera |
| spellingShingle | Afianti Sulastri Natasya Natasya Muhammad Naufal Abdurahman Pipit Pitriani Hamidie Ronald Daniel Ray The Effect of Moringa leaf extract supplementation on IL-6 protein expression in endurance-training-induced inflammation of Wistar rat muscles Jurnal Pendidikan Jasmani dan Olahraga anti-inflammatory, endurance training, il-6, moringa oleifera |
| title | The Effect of Moringa leaf extract supplementation on IL-6 protein expression in endurance-training-induced inflammation of Wistar rat muscles |
| title_full | The Effect of Moringa leaf extract supplementation on IL-6 protein expression in endurance-training-induced inflammation of Wistar rat muscles |
| title_fullStr | The Effect of Moringa leaf extract supplementation on IL-6 protein expression in endurance-training-induced inflammation of Wistar rat muscles |
| title_full_unstemmed | The Effect of Moringa leaf extract supplementation on IL-6 protein expression in endurance-training-induced inflammation of Wistar rat muscles |
| title_short | The Effect of Moringa leaf extract supplementation on IL-6 protein expression in endurance-training-induced inflammation of Wistar rat muscles |
| title_sort | effect of moringa leaf extract supplementation on il 6 protein expression in endurance training induced inflammation of wistar rat muscles |
| topic | anti-inflammatory, endurance training, il-6, moringa oleifera |
| url | https://ejournal.upi.edu/index.php/penjas/article/view/56199 |
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