Surveillance of anti-tuberculosis drug resistance in the world: an updated analysis, 2007-2010
OBJECTIVE: To present a global update of drug-resistant tuberculosis (TB) and explore trends in 1994-2010. METHODS: Data on drug resistance among new and previously treated TB patients, as reported by countries to the World Health Organization, were analysed. Such data are collected through surveys...
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| Format: | Article |
| Language: | English |
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The World Health Organization
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| Series: | Bulletin of the World Health Organization |
| Online Access: | http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0042-96862012000200011&lng=en&tlng=en |
| _version_ | 1827333692639412224 |
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| author | Matteo Zignol Wayne van Gemert Dennis Falzon Charalambos Sismanidis Philippe Glaziou Katherine Floyd Mario Raviglione |
| author_facet | Matteo Zignol Wayne van Gemert Dennis Falzon Charalambos Sismanidis Philippe Glaziou Katherine Floyd Mario Raviglione |
| author_sort | Matteo Zignol |
| collection | DOAJ |
| description | OBJECTIVE: To present a global update of drug-resistant tuberculosis (TB) and explore trends in 1994-2010. METHODS: Data on drug resistance among new and previously treated TB patients, as reported by countries to the World Health Organization, were analysed. Such data are collected through surveys of a representative sample of TB patients or surveillance systems based on routine drug susceptibility testing. Associations between multidrug-resistant TB (MDR-TB) and human immunodeficiency virus (HIV) infection and sex were explored through logistic regression. FINDINGS: In 2007-2010, 80 countries and 8 territories reported surveillance data. MDR-TB among new and previously treated cases was highest in the Russian Federation (Murmansk oblast, 28.9%) and the Republic of Moldova (65.1%), respectively. In three former Soviet Union countries and South Africa, more than 10% of the cases of MDR-TB were extensively drug-resistant. Globally, in 1994 to 2010 multidrug resistance was observed in 3.4% (95% confidence interval, CI: 1.9-5.0) of all new TB cases and in 19.8% (95% CI: 14.4-25.1) of previously treated TB cases. No overall associations between MDR-TB and HIV infection (odds ratio, OR: 1.4; 95% CI: 0.7-3.0) or sex (OR: 1.1; 95% CI: 0.8-1.4) were found. Between 1994 and 2010, MDR-TB rates in the general population increased in Botswana, Peru, the Republic of Korea and declined in Estonia, Latvia and the United States of America. CONCLUSION: The highest global rates of MDR-TB ever reported were documented in 2009 and 2010. Trends in MDR-TB are still unclear in most settings. Better surveillance or survey data are required, especially from Africa and India. |
| first_indexed | 2024-03-07T17:33:07Z |
| format | Article |
| id | doaj.art-7f7b0f1656df46f0893db5e20d33f64b |
| institution | Directory Open Access Journal |
| issn | 0042-9686 |
| language | English |
| last_indexed | 2024-03-07T17:33:07Z |
| publisher | The World Health Organization |
| record_format | Article |
| series | Bulletin of the World Health Organization |
| spelling | doaj.art-7f7b0f1656df46f0893db5e20d33f64b2024-03-02T17:32:40ZengThe World Health OrganizationBulletin of the World Health Organization0042-968690211111910.1590/S0042-96862012000200011S0042-96862012000200011Surveillance of anti-tuberculosis drug resistance in the world: an updated analysis, 2007-2010Matteo Zignol0Wayne van Gemert1Dennis Falzon2Charalambos Sismanidis3Philippe Glaziou4Katherine Floyd5Mario Raviglione6World Health OrganizationWorld Health OrganizationWorld Health OrganizationWorld Health OrganizationWorld Health OrganizationWorld Health OrganizationWorld Health OrganizationOBJECTIVE: To present a global update of drug-resistant tuberculosis (TB) and explore trends in 1994-2010. METHODS: Data on drug resistance among new and previously treated TB patients, as reported by countries to the World Health Organization, were analysed. Such data are collected through surveys of a representative sample of TB patients or surveillance systems based on routine drug susceptibility testing. Associations between multidrug-resistant TB (MDR-TB) and human immunodeficiency virus (HIV) infection and sex were explored through logistic regression. FINDINGS: In 2007-2010, 80 countries and 8 territories reported surveillance data. MDR-TB among new and previously treated cases was highest in the Russian Federation (Murmansk oblast, 28.9%) and the Republic of Moldova (65.1%), respectively. In three former Soviet Union countries and South Africa, more than 10% of the cases of MDR-TB were extensively drug-resistant. Globally, in 1994 to 2010 multidrug resistance was observed in 3.4% (95% confidence interval, CI: 1.9-5.0) of all new TB cases and in 19.8% (95% CI: 14.4-25.1) of previously treated TB cases. No overall associations between MDR-TB and HIV infection (odds ratio, OR: 1.4; 95% CI: 0.7-3.0) or sex (OR: 1.1; 95% CI: 0.8-1.4) were found. Between 1994 and 2010, MDR-TB rates in the general population increased in Botswana, Peru, the Republic of Korea and declined in Estonia, Latvia and the United States of America. CONCLUSION: The highest global rates of MDR-TB ever reported were documented in 2009 and 2010. Trends in MDR-TB are still unclear in most settings. Better surveillance or survey data are required, especially from Africa and India.http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0042-96862012000200011&lng=en&tlng=en |
| spellingShingle | Matteo Zignol Wayne van Gemert Dennis Falzon Charalambos Sismanidis Philippe Glaziou Katherine Floyd Mario Raviglione Surveillance of anti-tuberculosis drug resistance in the world: an updated analysis, 2007-2010 Bulletin of the World Health Organization |
| title | Surveillance of anti-tuberculosis drug resistance in the world: an updated analysis, 2007-2010 |
| title_full | Surveillance of anti-tuberculosis drug resistance in the world: an updated analysis, 2007-2010 |
| title_fullStr | Surveillance of anti-tuberculosis drug resistance in the world: an updated analysis, 2007-2010 |
| title_full_unstemmed | Surveillance of anti-tuberculosis drug resistance in the world: an updated analysis, 2007-2010 |
| title_short | Surveillance of anti-tuberculosis drug resistance in the world: an updated analysis, 2007-2010 |
| title_sort | surveillance of anti tuberculosis drug resistance in the world an updated analysis 2007 2010 |
| url | http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0042-96862012000200011&lng=en&tlng=en |
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