Modeling of <i>FAN1</i>-Deficient Kidney Disease Using a Human Induced Pluripotent Stem Cell-Derived Kidney Organoid System

Modeling of <i>FAN1</i>-Deficient Kidney Disease Using a Human Induced Pluripotent Stem Cell-Derived Kidney Organoid System

Karyomegalic interstitial nephritis (KIN) is a genetic kidney disease caused by mutations in the FANCD2/FANCI-Associated Nuclease 1 (<i>FAN1</i>) gene on 15q13.3, which results in karyomegaly and fibrosis of kidney cells through the incomplete repair of DNA damage. The aim of this study...

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Bibliographic Details
Main Authors:	Sun Woo Lim, Dohyun Na, Hanbi Lee, Xianying Fang, Sheng Cui, Yoo Jin Shin, Kang In Lee, Jae Young Lee, Chul Woo Yang, Byung Ha Chung
Format:	Article
Language:	English
Published:	MDPI AG 2023-09-01
Series:	Cells
Subjects:	<i>FAN1</i> gene induced pluripotent stem cells kidney organoid karyomegalic interstitial nephritis
Online Access:	https://www.mdpi.com/2073-4409/12/18/2319

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