Camillo Golgi’s Impact on Malaria Studies
Camillo Golgi was an esteemed Italian physician and biologist who made major advances in malaria research between the late 19th and early 20th centuries. His groundbreaking contributions in histology, especially through the development of the Golgi staining technique, revolutionized our understandin...
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MDPI AG
2023-08-01
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| Series: | Cells |
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| author | Madalina Simoiu Radu Codreanu Antonio-Daniel Corlatescu Andreeea Marilena Pauna Suzana Elena Cilievici |
| author_facet | Madalina Simoiu Radu Codreanu Antonio-Daniel Corlatescu Andreeea Marilena Pauna Suzana Elena Cilievici |
| author_sort | Madalina Simoiu |
| collection | DOAJ |
| description | Camillo Golgi was an esteemed Italian physician and biologist who made major advances in malaria research between the late 19th and early 20th centuries. His groundbreaking contributions in histology, especially through the development of the Golgi staining technique, revolutionized our understanding of cell structures—including <i>Plasmodium</i> parasites—through visualization. Golgi staining also allowed researchers to observe its complex life cycle while documenting it. His careful observations of malaria led to the identification and characterization of its various stages, both asexual forms within human red blood cells, as well as sexual forms carried by mosquito vectors. Golgi’s research highlighted the key role mosquitoes play in malaria transmission. He demonstrated the presence of <i>Plasmodium</i> sporozoites within the salivary glands of infected mosquitoes, providing insight into its life cycle and the dynamics of parasite transmission. His comprehensive approach contributed significantly to our understanding of malaria as a systemic illness, leading to subsequent research efforts within this field. The Golgi Protein complex is often located within the cis-Golgi of blood parasite life cycles and mosquito stages, indicating its possible role in optimizing asexual development during blood stages. Furthermore, its expression can be conditionally repressed or its gene can be inactivated to optimize this potential role in improving its functionality for optimizing sexual development during blood stages. Camillo Golgi remains one of the leading lights of malaria research today. His innovative staining techniques, detailed observations, and insightful interpretations have laid the groundwork for subsequent discoveries and advancements in malaria studies. By deciphering intricate parasite life cycle interactions with hosts, his work has provided invaluable insights into malaria biology, pathogenesis, and epidemiology. |
| first_indexed | 2024-03-10T23:25:49Z |
| format | Article |
| id | doaj.art-7f7cbb7719b24de091d806afe7d672cf |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T23:25:49Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-7f7cbb7719b24de091d806afe7d672cf2023-11-19T07:58:02ZengMDPI AGCells2073-44092023-08-011217215610.3390/cells12172156Camillo Golgi’s Impact on Malaria StudiesMadalina Simoiu0Radu Codreanu1Antonio-Daniel Corlatescu2Andreeea Marilena Pauna3Suzana Elena Cilievici4Department of Parasitology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Parasitology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Epidemiology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Parasitology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaCamillo Golgi was an esteemed Italian physician and biologist who made major advances in malaria research between the late 19th and early 20th centuries. His groundbreaking contributions in histology, especially through the development of the Golgi staining technique, revolutionized our understanding of cell structures—including <i>Plasmodium</i> parasites—through visualization. Golgi staining also allowed researchers to observe its complex life cycle while documenting it. His careful observations of malaria led to the identification and characterization of its various stages, both asexual forms within human red blood cells, as well as sexual forms carried by mosquito vectors. Golgi’s research highlighted the key role mosquitoes play in malaria transmission. He demonstrated the presence of <i>Plasmodium</i> sporozoites within the salivary glands of infected mosquitoes, providing insight into its life cycle and the dynamics of parasite transmission. His comprehensive approach contributed significantly to our understanding of malaria as a systemic illness, leading to subsequent research efforts within this field. The Golgi Protein complex is often located within the cis-Golgi of blood parasite life cycles and mosquito stages, indicating its possible role in optimizing asexual development during blood stages. Furthermore, its expression can be conditionally repressed or its gene can be inactivated to optimize this potential role in improving its functionality for optimizing sexual development during blood stages. Camillo Golgi remains one of the leading lights of malaria research today. His innovative staining techniques, detailed observations, and insightful interpretations have laid the groundwork for subsequent discoveries and advancements in malaria studies. By deciphering intricate parasite life cycle interactions with hosts, his work has provided invaluable insights into malaria biology, pathogenesis, and epidemiology.https://www.mdpi.com/2073-4409/12/17/2156Camillo Golgimalaria researchhistologyGolgi staining techniquecellular structures<i>Plasmodium</i> |
| spellingShingle | Madalina Simoiu Radu Codreanu Antonio-Daniel Corlatescu Andreeea Marilena Pauna Suzana Elena Cilievici Camillo Golgi’s Impact on Malaria Studies Cells Camillo Golgi malaria research histology Golgi staining technique cellular structures <i>Plasmodium</i> |
| title | Camillo Golgi’s Impact on Malaria Studies |
| title_full | Camillo Golgi’s Impact on Malaria Studies |
| title_fullStr | Camillo Golgi’s Impact on Malaria Studies |
| title_full_unstemmed | Camillo Golgi’s Impact on Malaria Studies |
| title_short | Camillo Golgi’s Impact on Malaria Studies |
| title_sort | camillo golgi s impact on malaria studies |
| topic | Camillo Golgi malaria research histology Golgi staining technique cellular structures <i>Plasmodium</i> |
| url | https://www.mdpi.com/2073-4409/12/17/2156 |
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