Does increased body mass index lead to elevated prostate cancer risk? It depends on waist circumference
Abstract Background We examined the association between obesity and prostate cancer based on both body mass index (BMI) and waist circumference (WC) using the National Health Insurance System (NHIS) database for the entire male population of Korea. Methods A total of 1,917,430 men who underwent at l...
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| Format: | Article |
| Language: | English |
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BMC
2020-06-01
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| Series: | BMC Cancer |
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| Online Access: | http://link.springer.com/article/10.1186/s12885-020-07089-5 |
| _version_ | 1818967169389559808 |
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| author | Jin Bong Choi Jun-Pyo Myong Yunhee Lee Inah Kim Jung Ho Kim Sung-Hoo Hong U-Syn Ha |
| author_facet | Jin Bong Choi Jun-Pyo Myong Yunhee Lee Inah Kim Jung Ho Kim Sung-Hoo Hong U-Syn Ha |
| author_sort | Jin Bong Choi |
| collection | DOAJ |
| description | Abstract Background We examined the association between obesity and prostate cancer based on both body mass index (BMI) and waist circumference (WC) using the National Health Insurance System (NHIS) database for the entire male population of Korea. Methods A total of 1,917,430 men who underwent at least one health examination in 2009 without a previous diagnosis of any other cancer were tracked through December 2015. The hazard ratio (HR) and 95% confidence interval (CI) value for the association between prostate cancer and obesity were analyzed using multiple Cox regression model. Since there was a statistically significant interaction between WC and BMI, a multiple HR for prostate cancer was estimated with stratifying both WC and BMI to control the interaction between WC and BMI. Results Without considering WC as an adjustment factor, very weak association between BMI and prostate cancer development risk was observed. When WC was considered as an adjustment factor, no significant change in the HRs for prostate cancer development beyond the reference BMI was observed in the group with WC < 85 cm in the multivariable-adjusted models. However, in the group with WC ≥ 85 cm, the HRs for prostate cancer increased as the BMI increased beyond the reference BMI. In addition, there was a discrepancy in the trend of prostate cancer development according to BMI among the groups with different categories for WC. Conclusion In groups with abdominal obesity, a significant linear relationship was observed between increasing BMI and prostate cancer risk. Higher the WC category, the stronger was the association with BMI, signifying that the association of BMI with risk of prostate cancer development depends on abdominal obesity. |
| first_indexed | 2024-12-20T13:44:31Z |
| format | Article |
| id | doaj.art-7f7cf514c0e8460cb29e5ec200a30f3b |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-20T13:44:31Z |
| publishDate | 2020-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-7f7cf514c0e8460cb29e5ec200a30f3b2022-12-21T19:38:44ZengBMCBMC Cancer1471-24072020-06-012011810.1186/s12885-020-07089-5Does increased body mass index lead to elevated prostate cancer risk? It depends on waist circumferenceJin Bong Choi0Jun-Pyo Myong1Yunhee Lee2Inah Kim3Jung Ho Kim4Sung-Hoo Hong5U-Syn Ha6Department of Urology, Bucheon St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDepartment of Occupational and Environmental Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDepartment of Occupational and Environmental Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDepartment of Occupational and Environmental Medicine, Hanyang University College of MedicineDepartment of Urology, Dongnam Institute of Radiological & Medical Sciences, Cancer CenterDepartment of Urology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDepartment of Urology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaAbstract Background We examined the association between obesity and prostate cancer based on both body mass index (BMI) and waist circumference (WC) using the National Health Insurance System (NHIS) database for the entire male population of Korea. Methods A total of 1,917,430 men who underwent at least one health examination in 2009 without a previous diagnosis of any other cancer were tracked through December 2015. The hazard ratio (HR) and 95% confidence interval (CI) value for the association between prostate cancer and obesity were analyzed using multiple Cox regression model. Since there was a statistically significant interaction between WC and BMI, a multiple HR for prostate cancer was estimated with stratifying both WC and BMI to control the interaction between WC and BMI. Results Without considering WC as an adjustment factor, very weak association between BMI and prostate cancer development risk was observed. When WC was considered as an adjustment factor, no significant change in the HRs for prostate cancer development beyond the reference BMI was observed in the group with WC < 85 cm in the multivariable-adjusted models. However, in the group with WC ≥ 85 cm, the HRs for prostate cancer increased as the BMI increased beyond the reference BMI. In addition, there was a discrepancy in the trend of prostate cancer development according to BMI among the groups with different categories for WC. Conclusion In groups with abdominal obesity, a significant linear relationship was observed between increasing BMI and prostate cancer risk. Higher the WC category, the stronger was the association with BMI, signifying that the association of BMI with risk of prostate cancer development depends on abdominal obesity.http://link.springer.com/article/10.1186/s12885-020-07089-5Prostate cancerObesityWaist circumference |
| spellingShingle | Jin Bong Choi Jun-Pyo Myong Yunhee Lee Inah Kim Jung Ho Kim Sung-Hoo Hong U-Syn Ha Does increased body mass index lead to elevated prostate cancer risk? It depends on waist circumference BMC Cancer Prostate cancer Obesity Waist circumference |
| title | Does increased body mass index lead to elevated prostate cancer risk? It depends on waist circumference |
| title_full | Does increased body mass index lead to elevated prostate cancer risk? It depends on waist circumference |
| title_fullStr | Does increased body mass index lead to elevated prostate cancer risk? It depends on waist circumference |
| title_full_unstemmed | Does increased body mass index lead to elevated prostate cancer risk? It depends on waist circumference |
| title_short | Does increased body mass index lead to elevated prostate cancer risk? It depends on waist circumference |
| title_sort | does increased body mass index lead to elevated prostate cancer risk it depends on waist circumference |
| topic | Prostate cancer Obesity Waist circumference |
| url | http://link.springer.com/article/10.1186/s12885-020-07089-5 |
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