Pulmonary Alveolar Proteinosis and Pregnancy: A Review of the Literature and Case Presentation
Pulmonary Alveolar Proteinosis (PAP) is a rare, usually autoimmune, disease, where surfactant accumulates within alveoli due to decreased clearance, causing dyspnea and hypoxemia. The disease is even more rare in pregnancy; nevertheless, it has been reported in pregnant women and can even appear for...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/58/8/984 |
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| author | Brindusa Ana Cimpoca Raptis Anca Maria Panaitescu Gheorghe Peltecu Nicolae Gica Radu Botezatu Mihaela Roxana Popescu Anca Macri Ana Constantin Bogdan Pavel |
| author_facet | Brindusa Ana Cimpoca Raptis Anca Maria Panaitescu Gheorghe Peltecu Nicolae Gica Radu Botezatu Mihaela Roxana Popescu Anca Macri Ana Constantin Bogdan Pavel |
| author_sort | Brindusa Ana Cimpoca Raptis |
| collection | DOAJ |
| description | Pulmonary Alveolar Proteinosis (PAP) is a rare, usually autoimmune, disease, where surfactant accumulates within alveoli due to decreased clearance, causing dyspnea and hypoxemia. The disease is even more rare in pregnancy; nevertheless, it has been reported in pregnant women and can even appear for the first time during pregnancy as an asthma-like illness. Therefore, awareness is important. Similarly to many autoimmune diseases, it can worsen during pregnancy and postpartum, causing maternal and fetal/neonatal complications. This paper offers a narrative literature review of PAP and pregnancy, while illustrating a case of a pregnant patient with known PAP who developed preeclampsia in the third trimester but had an overall fortunate maternal and neonatal outcome. |
| first_indexed | 2024-03-09T04:07:49Z |
| format | Article |
| id | doaj.art-7f7f5d957ce1437b95052a0ac014005d |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T04:07:49Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-7f7f5d957ce1437b95052a0ac014005d2023-12-03T14:04:15ZengMDPI AGMedicina1010-660X1648-91442022-07-0158898410.3390/medicina58080984Pulmonary Alveolar Proteinosis and Pregnancy: A Review of the Literature and Case PresentationBrindusa Ana Cimpoca Raptis0Anca Maria Panaitescu1Gheorghe Peltecu2Nicolae Gica3Radu Botezatu4Mihaela Roxana Popescu5Anca Macri6Ana Constantin7Bogdan Pavel8Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, RomaniaCardiothoracic Pathology Department, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Pneumology, Marius Nasta National Institute of Pneumology, 050159 Bucharest, RomaniaDepartment of Pneumology, Marius Nasta National Institute of Pneumology, 050159 Bucharest, RomaniaDepartment of Functional Sciences, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaPulmonary Alveolar Proteinosis (PAP) is a rare, usually autoimmune, disease, where surfactant accumulates within alveoli due to decreased clearance, causing dyspnea and hypoxemia. The disease is even more rare in pregnancy; nevertheless, it has been reported in pregnant women and can even appear for the first time during pregnancy as an asthma-like illness. Therefore, awareness is important. Similarly to many autoimmune diseases, it can worsen during pregnancy and postpartum, causing maternal and fetal/neonatal complications. This paper offers a narrative literature review of PAP and pregnancy, while illustrating a case of a pregnant patient with known PAP who developed preeclampsia in the third trimester but had an overall fortunate maternal and neonatal outcome.https://www.mdpi.com/1648-9144/58/8/984pulmonary alveolar proteinosispulmonary alveolar lipoproteinosispregnancy complicationsauto-antibodiesmaternal–fetal transfer |
| spellingShingle | Brindusa Ana Cimpoca Raptis Anca Maria Panaitescu Gheorghe Peltecu Nicolae Gica Radu Botezatu Mihaela Roxana Popescu Anca Macri Ana Constantin Bogdan Pavel Pulmonary Alveolar Proteinosis and Pregnancy: A Review of the Literature and Case Presentation Medicina pulmonary alveolar proteinosis pulmonary alveolar lipoproteinosis pregnancy complications auto-antibodies maternal–fetal transfer |
| title | Pulmonary Alveolar Proteinosis and Pregnancy: A Review of the Literature and Case Presentation |
| title_full | Pulmonary Alveolar Proteinosis and Pregnancy: A Review of the Literature and Case Presentation |
| title_fullStr | Pulmonary Alveolar Proteinosis and Pregnancy: A Review of the Literature and Case Presentation |
| title_full_unstemmed | Pulmonary Alveolar Proteinosis and Pregnancy: A Review of the Literature and Case Presentation |
| title_short | Pulmonary Alveolar Proteinosis and Pregnancy: A Review of the Literature and Case Presentation |
| title_sort | pulmonary alveolar proteinosis and pregnancy a review of the literature and case presentation |
| topic | pulmonary alveolar proteinosis pulmonary alveolar lipoproteinosis pregnancy complications auto-antibodies maternal–fetal transfer |
| url | https://www.mdpi.com/1648-9144/58/8/984 |
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