Sex differences in natural history of cardiovascular magnetic resonance‐ and biopsy‐proven lymphocytic myocarditis
Abstract Aims The role of sex in determining the profile and the outcomes of patients with myocarditis is largely unexplored. We evaluated the impact of sex as a modifier factor in the clinical characterization and natural history of patients with definite diagnosis of myocarditis. Methods and resul...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-12-01
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| Series: | ESC Heart Failure |
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| Online Access: | https://doi.org/10.1002/ehf2.14102 |
| _version_ | 1797979247161114624 |
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| author | Matteo Castrichini Aldostefano Porcari Chiara Baggio Giulia Gagno Davide Maione Giulia Barbati Kristen Medo Luisa Mestroni Marco Merlo Gianfranco Sinagra |
| author_facet | Matteo Castrichini Aldostefano Porcari Chiara Baggio Giulia Gagno Davide Maione Giulia Barbati Kristen Medo Luisa Mestroni Marco Merlo Gianfranco Sinagra |
| author_sort | Matteo Castrichini |
| collection | DOAJ |
| description | Abstract Aims The role of sex in determining the profile and the outcomes of patients with myocarditis is largely unexplored. We evaluated the impact of sex as a modifier factor in the clinical characterization and natural history of patients with definite diagnosis of myocarditis. Methods and results We retrospectively analysed a single‐centre cohort of consecutive patients with definite diagnosis of myocarditis (i.e. endomyocardial biopsy or cardiac magnetic resonance proven). Specific sub‐analyses were performed in cohorts of patients with chest pain, ventricular arrhythmias, and heart failure as different main symptoms at presentation. The primary outcome measure was a composite of all‐cause mortality or heart transplantation (HTx). We included 312 patients, of which 211, 68% of the whole population, were males. Despite no clinically relevant differences found at baseline presentation, males had a higher indexed left ventricular end‐diastolic volume (62 ± 23 mL/m2 vs. 52 ± 20 mL/m2, P = 0.011 in males vs. females, respectively) at follow‐up evaluation. At a median follow‐up of 72 months, 36 (17%) males vs. 8 (8%) females experienced death or HTx (P = 0.033). Male sex emerged as predictors of all‐cause mortality or HTx in every combination of covariates (HR 2.600; 1.163–5.809; P = 0.020). Results were agreeable regardless of the main symptom of presentation. Conclusions In a large cohort of patients with definite diagnosis of myocarditis, females experienced a more favourable long‐term prognosis than males, despite a similar clinical profile at presentation. |
| first_indexed | 2024-04-11T05:35:56Z |
| format | Article |
| id | doaj.art-7f82ee1c2e0f4e9baf72d2994cc4a622 |
| institution | Directory Open Access Journal |
| issn | 2055-5822 |
| language | English |
| last_indexed | 2024-04-11T05:35:56Z |
| publishDate | 2022-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj.art-7f82ee1c2e0f4e9baf72d2994cc4a6222022-12-22T12:55:33ZengWileyESC Heart Failure2055-58222022-12-01964010401910.1002/ehf2.14102Sex differences in natural history of cardiovascular magnetic resonance‐ and biopsy‐proven lymphocytic myocarditisMatteo Castrichini0Aldostefano Porcari1Chiara Baggio2Giulia Gagno3Davide Maione4Giulia Barbati5Kristen Medo6Luisa Mestroni7Marco Merlo8Gianfranco Sinagra9Center for Diagnosis and Treatment of Cardiomyopathies, Cardiovascular Department Azienda Sanitaria Universitaria Giuliano‐Isontina (ASUGI), University of Trieste, European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart‐ERN GUARD‐Heart Trieste ItalyCenter for Diagnosis and Treatment of Cardiomyopathies, Cardiovascular Department Azienda Sanitaria Universitaria Giuliano‐Isontina (ASUGI), University of Trieste, European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart‐ERN GUARD‐Heart Trieste ItalyCenter for Diagnosis and Treatment of Cardiomyopathies, Cardiovascular Department Azienda Sanitaria Universitaria Giuliano‐Isontina (ASUGI), University of Trieste, European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart‐ERN GUARD‐Heart Trieste ItalyCenter for Diagnosis and Treatment of Cardiomyopathies, Cardiovascular Department Azienda Sanitaria Universitaria Giuliano‐Isontina (ASUGI), University of Trieste, European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart‐ERN GUARD‐Heart Trieste ItalyCenter for Diagnosis and Treatment of Cardiomyopathies, Cardiovascular Department Azienda Sanitaria Universitaria Giuliano‐Isontina (ASUGI), University of Trieste, European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart‐ERN GUARD‐Heart Trieste ItalyBiostatistics Unit, Department of Medical Sciences University of Trieste Trieste ItalyDivision of Cardiology University of Colorado Anschutz Medical Campus Aurora CO USADivision of Cardiology University of Colorado Anschutz Medical Campus Aurora CO USACenter for Diagnosis and Treatment of Cardiomyopathies, Cardiovascular Department Azienda Sanitaria Universitaria Giuliano‐Isontina (ASUGI), University of Trieste, European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart‐ERN GUARD‐Heart Trieste ItalyCenter for Diagnosis and Treatment of Cardiomyopathies, Cardiovascular Department Azienda Sanitaria Universitaria Giuliano‐Isontina (ASUGI), University of Trieste, European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart‐ERN GUARD‐Heart Trieste ItalyAbstract Aims The role of sex in determining the profile and the outcomes of patients with myocarditis is largely unexplored. We evaluated the impact of sex as a modifier factor in the clinical characterization and natural history of patients with definite diagnosis of myocarditis. Methods and results We retrospectively analysed a single‐centre cohort of consecutive patients with definite diagnosis of myocarditis (i.e. endomyocardial biopsy or cardiac magnetic resonance proven). Specific sub‐analyses were performed in cohorts of patients with chest pain, ventricular arrhythmias, and heart failure as different main symptoms at presentation. The primary outcome measure was a composite of all‐cause mortality or heart transplantation (HTx). We included 312 patients, of which 211, 68% of the whole population, were males. Despite no clinically relevant differences found at baseline presentation, males had a higher indexed left ventricular end‐diastolic volume (62 ± 23 mL/m2 vs. 52 ± 20 mL/m2, P = 0.011 in males vs. females, respectively) at follow‐up evaluation. At a median follow‐up of 72 months, 36 (17%) males vs. 8 (8%) females experienced death or HTx (P = 0.033). Male sex emerged as predictors of all‐cause mortality or HTx in every combination of covariates (HR 2.600; 1.163–5.809; P = 0.020). Results were agreeable regardless of the main symptom of presentation. Conclusions In a large cohort of patients with definite diagnosis of myocarditis, females experienced a more favourable long‐term prognosis than males, despite a similar clinical profile at presentation.https://doi.org/10.1002/ehf2.14102Sex differencesMyocarditisEpidemiologyPrognosis |
| spellingShingle | Matteo Castrichini Aldostefano Porcari Chiara Baggio Giulia Gagno Davide Maione Giulia Barbati Kristen Medo Luisa Mestroni Marco Merlo Gianfranco Sinagra Sex differences in natural history of cardiovascular magnetic resonance‐ and biopsy‐proven lymphocytic myocarditis ESC Heart Failure Sex differences Myocarditis Epidemiology Prognosis |
| title | Sex differences in natural history of cardiovascular magnetic resonance‐ and biopsy‐proven lymphocytic myocarditis |
| title_full | Sex differences in natural history of cardiovascular magnetic resonance‐ and biopsy‐proven lymphocytic myocarditis |
| title_fullStr | Sex differences in natural history of cardiovascular magnetic resonance‐ and biopsy‐proven lymphocytic myocarditis |
| title_full_unstemmed | Sex differences in natural history of cardiovascular magnetic resonance‐ and biopsy‐proven lymphocytic myocarditis |
| title_short | Sex differences in natural history of cardiovascular magnetic resonance‐ and biopsy‐proven lymphocytic myocarditis |
| title_sort | sex differences in natural history of cardiovascular magnetic resonance and biopsy proven lymphocytic myocarditis |
| topic | Sex differences Myocarditis Epidemiology Prognosis |
| url | https://doi.org/10.1002/ehf2.14102 |
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