High flow nasal therapy versus noninvasive ventilation as initial ventilatory strategy in COPD exacerbation: a multicenter non-inferiority randomized trial

High flow nasal therapy versus noninvasive ventilation as initial ventilatory strategy in COPD exacerbation: a multicenter non-inferiority randomized trial

Abstract Background The efficacy and safety of high flow nasal therapy (HFNT) in patients with acute hypercapnic exacerbation of chronic obstructive pulmonary disease (AECOPD) are unclear. Our aim was to evaluate the short-term effect of HFNT versus NIV in patients with mild-to-moderate AECOPD, with...

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Main Authors: Andrea Cortegiani, Federico Longhini, Fabiana Madotto, Paolo Groff, Raffaele Scala, Claudia Crimi, Annalisa Carlucci, Andrea Bruni, Eugenio Garofalo, Santi Maurizio Raineri, Roberto Tonelli, Vittoria Comellini, Enrico Lupia, Luigi Vetrugno, Enrico Clini, Antonino Giarratano, Stefano Nava, Paolo Navalesi, Cesare Gregoretti, the H. F.-AECOPD study investigators
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Critical Care
Subjects:
High flow nasal therapy
High flow nasal cannula
Noninvasive ventilation
Chronic obstructive pulmonary disease
Acute respiratory failure
Online Access:https://doi.org/10.1186/s13054-020-03409-0

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