PTTG1 promotes CD34+CD45+ cells to repair the pulmonary vascular barrier via activating the VEGF-bFGF/PI3K/AKT/eNOS signaling pathway in rats with phosgene-induced acute lung injury

PTTG1 promotes CD34+CD45+ cells to repair the pulmonary vascular barrier via activating the VEGF-bFGF/PI3K/AKT/eNOS signaling pathway in rats with phosgene-induced acute lung injury

Accidental exposure to phosgene can cause acute lung injury (ALI), characterized by uncontrolled inflammation and impaired lung blood-gas barrier. CD34+CD45+ cells with high pituitary tumor transforming gene 1 (PTTG1) expression were identified around rat pulmonary vessels through single-cell RNA se...

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Bibliographic Details
Main Authors: Yu Dun, Hanbing Hu, Fuli Liu, Yiru Shao, Daikun He, Lin Zhang, Jie Shen
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Biomedicine & Pharmacotherapy
Subjects:
CD34+CD45+ cells
PTTG1
Endothelial differentiation
Pulmonary vascular barrier
Phosgene
VEGF-bFGF/PI3K/AKT/eNOS signaling pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223004420

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http://www.sciencedirect.com/science/article/pii/S0753332223004420

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