Association of serum free thyroxine and glucose homeostasis: Korea National Health and Nutrition Examination Survey
Background/Aims Thyroid hormones are involved in wide range of glucose metabolism functions. Overt thyroid dysfunctions are related to altered glucose homeostasis. However, it is not conclusive as to whether subtle changes in thyroid hormones within normal ranges can induce alterations in glucose ho...
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| Format: | Article |
| Language: | English |
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The Korean Association of Internal Medicine
2021-03-01
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| Series: | The Korean Journal of Internal Medicine |
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| Online Access: | http://www.kjim.org/upload/pdf/kjim-2019-160.pdf |
| _version_ | 1819126078445191168 |
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| author | Jeonghoon Ha Jeongmin Lee Dong-Jun Lim Jung-Min Lee Sang-Ah Chang Moo-Il Kang Min-Hee Kim |
| author_facet | Jeonghoon Ha Jeongmin Lee Dong-Jun Lim Jung-Min Lee Sang-Ah Chang Moo-Il Kang Min-Hee Kim |
| author_sort | Jeonghoon Ha |
| collection | DOAJ |
| description | Background/Aims Thyroid hormones are involved in wide range of glucose metabolism functions. Overt thyroid dysfunctions are related to altered glucose homeostasis. However, it is not conclusive as to whether subtle changes in thyroid hormones within normal ranges can induce alterations in glucose homeostasis. The aim of this study was to evaluate the association between thyroid hormone and glucose homeostasis parameters in subjects without overt thyroid dysfunction based on nationwide population data. Methods In the Sixth Korea National Health and Nutrition Examination Survey 2015 (n = 7,380), data were collected from subjects with insulin and thyroid function measurements who were older than 19-years-old. After the exclusion of 5,837 subjects, a total of 1,543 patients were included in the analysis. Subjects were categorized into the quartiles of the free thyroxine (FT4). Fasting glucose, insulin, homeostatic model assessment of insulin resistance and hemoglobin A1c (HbA1c) levels were considered to be glucose homeostasis parameters. Results Subjects with the highest FT4 quartile showed significantly lower fasting insulin and HbA1c levels. A significant inverse correlation FT4 and HbA1c levels was observed (β = –0.261, p = 0.025). In the logistic regression analysis, the highest quartile of FT4 was demonstrated to lower the risk of HbA1c to a greater degree than the median by approximately 40%, after adjusting for confounders, compared to the lowest quartile (p = 0.028). Conclusions We demonstrated subjects with a lower FT4 quartile exhibited high risk of HbA1c levels above the median value in a representative Korean population. Subjects with the lowest FT4 quartile should be cautiously managed in terms of altered glucose homeostasis. |
| first_indexed | 2024-12-22T07:50:19Z |
| format | Article |
| id | doaj.art-7f85b47e125f4baeb74c6b63d314bf4a |
| institution | Directory Open Access Journal |
| issn | 1226-3303 2005-6648 |
| language | English |
| last_indexed | 2024-12-22T07:50:19Z |
| publishDate | 2021-03-01 |
| publisher | The Korean Association of Internal Medicine |
| record_format | Article |
| series | The Korean Journal of Internal Medicine |
| spelling | doaj.art-7f85b47e125f4baeb74c6b63d314bf4a2022-12-21T18:33:30ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482021-03-0136Suppl 1S170S17910.3904/kjim.2019.160170386Association of serum free thyroxine and glucose homeostasis: Korea National Health and Nutrition Examination SurveyJeonghoon Ha0Jeongmin Lee1Dong-Jun Lim2Jung-Min Lee3Sang-Ah Chang4Moo-Il Kang5Min-Hee Kim6 Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, KoreaBackground/Aims Thyroid hormones are involved in wide range of glucose metabolism functions. Overt thyroid dysfunctions are related to altered glucose homeostasis. However, it is not conclusive as to whether subtle changes in thyroid hormones within normal ranges can induce alterations in glucose homeostasis. The aim of this study was to evaluate the association between thyroid hormone and glucose homeostasis parameters in subjects without overt thyroid dysfunction based on nationwide population data. Methods In the Sixth Korea National Health and Nutrition Examination Survey 2015 (n = 7,380), data were collected from subjects with insulin and thyroid function measurements who were older than 19-years-old. After the exclusion of 5,837 subjects, a total of 1,543 patients were included in the analysis. Subjects were categorized into the quartiles of the free thyroxine (FT4). Fasting glucose, insulin, homeostatic model assessment of insulin resistance and hemoglobin A1c (HbA1c) levels were considered to be glucose homeostasis parameters. Results Subjects with the highest FT4 quartile showed significantly lower fasting insulin and HbA1c levels. A significant inverse correlation FT4 and HbA1c levels was observed (β = –0.261, p = 0.025). In the logistic regression analysis, the highest quartile of FT4 was demonstrated to lower the risk of HbA1c to a greater degree than the median by approximately 40%, after adjusting for confounders, compared to the lowest quartile (p = 0.028). Conclusions We demonstrated subjects with a lower FT4 quartile exhibited high risk of HbA1c levels above the median value in a representative Korean population. Subjects with the lowest FT4 quartile should be cautiously managed in terms of altered glucose homeostasis.http://www.kjim.org/upload/pdf/kjim-2019-160.pdfthyroid hormonesblood glucoseinsulin resistanceglycated hemoglobin a |
| spellingShingle | Jeonghoon Ha Jeongmin Lee Dong-Jun Lim Jung-Min Lee Sang-Ah Chang Moo-Il Kang Min-Hee Kim Association of serum free thyroxine and glucose homeostasis: Korea National Health and Nutrition Examination Survey The Korean Journal of Internal Medicine thyroid hormones blood glucose insulin resistance glycated hemoglobin a |
| title | Association of serum free thyroxine and glucose homeostasis: Korea National Health and Nutrition Examination Survey |
| title_full | Association of serum free thyroxine and glucose homeostasis: Korea National Health and Nutrition Examination Survey |
| title_fullStr | Association of serum free thyroxine and glucose homeostasis: Korea National Health and Nutrition Examination Survey |
| title_full_unstemmed | Association of serum free thyroxine and glucose homeostasis: Korea National Health and Nutrition Examination Survey |
| title_short | Association of serum free thyroxine and glucose homeostasis: Korea National Health and Nutrition Examination Survey |
| title_sort | association of serum free thyroxine and glucose homeostasis korea national health and nutrition examination survey |
| topic | thyroid hormones blood glucose insulin resistance glycated hemoglobin a |
| url | http://www.kjim.org/upload/pdf/kjim-2019-160.pdf |
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