Identification of postsynaptic phosphatidylinositol-4,5-bisphosphate (PIP2) roles for synaptic plasticity using chemically induced dimerization

Identification of postsynaptic phosphatidylinositol-4,5-bisphosphate (PIP2) roles for synaptic plasticity using chemically induced dimerization

Abstract Phosphatidylinositol-4,5-bisphosphate (PIP2), one of the key phospholipids, directly interacts with several membrane and cytosolic proteins at neuronal plasma membranes, leading to changes in neuronal properties including the feature and surface expression of ionotropic receptors. Although...

Full description

Bibliographic Details
Main Authors:	Su-Jeong Kim, Min-Jae Jeong, Hee-Jung Jo, Jung Hoon Jung, Bong-Kiun Kaang, Yun-Beom Choi, Joung-Hun Kim
Format:	Article
Language:	English
Published:	Nature Portfolio 2017-06-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-017-03520-3

Similar Items

Phosphatidylinositol 4,5-bisphosphate (PIP2) facilitates norepinephrine transporter dimerization and modulates substrate efflux
by: Dino Luethi, et al.
Published: (2022-11-01)

Structure and Lateral Organization of Phosphatidylinositol 4,5-bisphosphate
by: Luís Borges-Araújo, et al.
Published: (2020-08-01)

Contrasting effects of phosphatidylinositol 4,5-bisphosphate (PIP2 ) on cloned TMEM16A and TMEM16B channels
by: Ta, C, et al.
Published: (2017)

Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis
by: Alexander M Walter, et al.
Published: (2017-10-01)

Absence of clustering of phosphatidylinositol-(4,5)-bisphosphate in fluid phosphatidylcholine
by: Faébio Fernandes, et al.
Published: (2006-07-01)

A dPIP5K dependent pool of phosphatidylinositol 4,5 bisphosphate (PIP2) is required for G-protein coupled signal transduction in Drosophila photoreceptors.
by: Purbani Chakrabarti, et al.
Published: (2015-01-01)

Optogenetic dephosphorylation of phosphatidylinositol 4,5 bisphosphate in Xenopus laevis oocytes
by: Kirin D. Gada, et al.
Published: (2023-03-01)

Long-term depression in neurons involves temporal and ultra-structural dynamics of phosphatidylinositol-4,5-bisphosphate relying on PIP5K, PTEN and PLC
by: Sarah A. Hofbrucker-MacKenzie, et al.
Published: (2023-04-01)

Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment.
by: Honigmann, A, et al.
Published: (2013)

Simulation-based prediction of phosphatidylinositol 4,5-bisphosphate binding to an ion channel.
by: Schmidt, MR, et al.
Published: (2013)

Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment
by: Honigmann, A, et al.
Published: (2013)

Plasma membrane phosphatidylinositol (4,5)-bisphosphate is critical for determination of epithelial characteristics
by: Kaori Kanemaru, et al.
Published: (2022-05-01)

Acyl-chain saturation regulates the order of phosphatidylinositol 4,5-bisphosphate nanodomains
by: Luís Borges-Araújo, et al.
Published: (2021-11-01)

Phosphatidylinositol (4,5) bisphosphate controls T cell activation by regulating T cell rigidity and organization.
by: Yi Sun, et al.
Published: (2011-01-01)

Role of phosphatidylinositol 4,5-bisphosphate in regulating EHD2 plasma membrane localization.
by: Laura C Simone, et al.
Published: (2013-01-01)

Cyclic AMP response element-binding protein (CREB) transcription factor in astrocytic synaptic communication
by: Jooyoung Kim, et al.
Published: (2023-01-01)

Structural characterization of the interaction between a Pleckstrin homology domain and phosphatidylinositol 4,5-bisphosphate
by: Harlan, John E., et al.
Published: (2012)

The Role of Class IA Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunits in Glioblastoma
by: Kevin J. Pridham, et al.
Published: (2017-12-01)

Phosphatidylinositol-4,5-bisphosphate enhances anionic lipid demixing by the C2 domain of PKCα.
by: Antonio L Egea-Jiménez, et al.
Published: (2014-01-01)

Phosphatidylinositol 4,5-Bisphosphate Is an HCV NS5A Ligand and Mediates Replication of the Viral Genome
by: Cho, Nam-Joon, et al.
Published: (2016)

Phosphatidylinositol-4,5-bisphosphate is required for KCNQ1/KCNE1 channel function but not anterograde trafficking.
by: Alice A Royal, et al.
Published: (2017-01-01)

A phosphatidylinositol 4,5-bisphosphate redistribution-based sensing mechanism initiates a phagocytosis programing
by: Libing Mu, et al.
Published: (2018-10-01)

Phosphatidylinositol-4,5-Bisphosphate Binding to Amphiphysin-II Modulates T-Tubule Remodeling: Implications for Heart Failure
by: Junlan Zhou, et al.
Published: (2021-12-01)

Increasing Phosphatidylinositol (4,5)-Bisphosphate Biosynthesis Affects Basal Signaling and Chloroplast Metabolism in Arabidopsis thaliana
by: Yang Ju Im, et al.
Published: (2014-01-01)

Long chain CoA esters as competitive antagonists of phosphatidylinositol 4,5-bisphosphate activation in Kir channels.
by: Rapedius, M, et al.
Published: (2005)

Limited Proteolysis-Coupled Mass Spectrometry Identifies Phosphatidylinositol 4,5-Bisphosphate Effectors in Human Nuclear Proteome
by: Martin Sztacho, et al.
Published: (2021-01-01)

Neomycin Interferes with Phosphatidylinositol-4,5-Bisphosphate at the Yeast Plasma Membrane and Activates the Cell Wall Integrity Pathway
by: Elena Jiménez-Gutiérrez, et al.
Published: (2022-09-01)

A genetically encoded tool kit for manipulating and monitoring membrane phosphatidylinositol 4,5-bisphosphate in intact cells.
by: Fabian Hertel, et al.
Published: (2011-01-01)

Amyloid β oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4,5-bisphosphate
by: Yang He, et al.
Published: (2019-03-01)

A long QT mutation substitutes cholesterol for phosphatidylinositol-4,5-bisphosphate in KCNQ1 channel regulation.
by: Fabien C Coyan, et al.
Published: (2014-01-01)

Identifying potential inhibitors of phosphatidylinositol 4,5-bisphosphate 3-kinase: Molecular dynamic insights into the interaction and inhibitory mechanism
by: Taj Mohammad, et al.
Published: (2024-06-01)

Fixation-induced cell blebbing on spread cells inversely correlates with phosphatidylinositol 4,5-bisphosphate level in the plasma membrane
by: Siyuan Zhao, et al.
Published: (2014-01-01)

Ca2+-dependent release of synaptotagmin-1 from the SNARE complex on phosphatidylinositol 4,5-bisphosphate-containing membranes
by: Rashmi Voleti, et al.
Published: (2020-08-01)

The distribution of phosphatidylinositol 4,5-bisphosphate in acinar cells of rat pancreas revealed with the freeze-fracture replica labeling method.
by: Nami Ozato-Sakurai, et al.
Published: (2011-01-01)

Selective Recruitment of Presynaptic and Postsynaptic Forms of mGluR-LTD
by: Thomas M. Sanderson, et al.
Published: (2022-05-01)

Lipid Messenger Phosphatidylinositol-4,5-Bisphosphate Is Increased by Both PPARα Activators and Inhibitors: Relevance for Intestinal Cell Differentiation
by: Katerina Cizkova, et al.
Published: (2022-06-01)

Phosphatidylinositol 4,5-Bisphosphate Mediates the Co-Distribution of Influenza A Hemagglutinin and Matrix Protein M1 at the Plasma Membrane
by: Prakash Raut, et al.
Published: (2022-11-01)

Membrane Binding and Subcellular Localization of Retroviral Gag Proteins Are Differentially Regulated by MA Interactions with Phosphatidylinositol-(4,5)-Bisphosphate and RNA
by: Jingga Inlora, et al.
Published: (2014-12-01)

Diverse Physiological Functions of FAB1 and Phosphatidylinositol 3,5-Bisphosphate in Plants
by: Tomoko Hirano, et al.
Published: (2019-03-01)

A novel micellular fluorogenic substrate for quantitating the activity of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma (PLCγ) enzymes.
by: Ramya Visvanathan, et al.
Published: (2024-01-01)