Correlation of immunostaining findings with demographic data and variables of Oxford classification in IgA nephropath
Background: Oxford classification for IgA nephropathy (IgAN) did not include pattern of immunostaining in the analysis. Objective: The aim of this study is to determine the potential correlation between the immunostaining data and morphologic variables of Oxford classification (MEST) and various cli...
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| Format: | Article |
| Language: | English |
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Society of Diabetic Nephropathy Prevention
2013-07-01
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| Series: | Journal of Nephropathology |
| Subjects: | |
| Online Access: | https://nephropathol.com/PDF/jnp-2-190.pdf |
| _version_ | 1827948552007974912 |
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| author | Hamid Nasri Shahram Sajjadieh Saeed Mardani Ali momeni Alireza Merikhi Yahya Madihi Alaleh Ghiessari Afsoon Emami Naieni |
| author_facet | Hamid Nasri Shahram Sajjadieh Saeed Mardani Ali momeni Alireza Merikhi Yahya Madihi Alaleh Ghiessari Afsoon Emami Naieni |
| author_sort | Hamid Nasri |
| collection | DOAJ |
| description | Background: Oxford classification for IgA nephropathy (IgAN) did not include pattern of immunostaining in the analysis. Objective: The aim of this study is to determine the potential correlation between the immunostaining data and morphologic variables of Oxford classification (MEST) and various clinical and demographic data of patients with IgAN. Patients and Methods: The pathologic diagnosis of IgAN requires the demonstration of IgA-dominant mesangial or mesangio-capillary immune deposits through immunofluorescence (IF) microscopy. The immune deposits were semiquantitatively assessed as 0 to 3+ positive bright. These were correlated with various clinical, demographic and histological variables of Oxford classification. Results: A total of 114 biopsies were enrolled to the study (70.2% were male). Mean age of the patients was 37.7 ± 13.6 years. This study showed that, only C3 deposits had a significant correlation with serum creatinine. Other antibodies (IgA, IgM and IgG) had no significant association with serum creatinine. This study also showed that IgA deposition score had significant positive association with endocapillary proliferation (E) and segmental glomerulosclerosis (S) variables of Oxford classification. Moreover, IgM deposition score had positive association with S variable. There was no significant association of IgG deposition score with four morphologic variables of Oxford classification. There was significant association of C3 deposition score with S and E variables too. Conclusions: The significant relationships of IgA and C3 deposits with some of the Oxford variables need more attention. We propose to further investigate this aspect of IgAN disease. |
| first_indexed | 2024-04-09T12:56:05Z |
| format | Article |
| id | doaj.art-7f8816bad30646d5893c49d888b24e5f |
| institution | Directory Open Access Journal |
| issn | 2251-8363 2251-8819 |
| language | English |
| last_indexed | 2024-04-09T12:56:05Z |
| publishDate | 2013-07-01 |
| publisher | Society of Diabetic Nephropathy Prevention |
| record_format | Article |
| series | Journal of Nephropathology |
| spelling | doaj.art-7f8816bad30646d5893c49d888b24e5f2023-05-13T11:43:00ZengSociety of Diabetic Nephropathy PreventionJournal of Nephropathology2251-83632251-88192013-07-012319019510.12860/JNP.2013.30JNP_20130930162140Correlation of immunostaining findings with demographic data and variables of Oxford classification in IgA nephropathHamid Nasri0Shahram Sajjadieh1Saeed Mardani2Ali momeni3Alireza Merikhi4Yahya Madihi5Alaleh Ghiessari6Afsoon Emami Naieni7Department of Nephrology, Isfahan University of Medical Sciences, Isfahan, Iran.Department of Nephrology, Isfahan University of Medical Sciences, Isfahan, Iran.Department of Nephrology, Shahrekord University of Medical Sciences, Shahrekord, Iran.Department of Nephrology, Shahrekord University of Medical Sciences, Shahrekord, Iran.Department of Nephrology, Isfahan University of Medical Sciences, Isfahan, Iran.Department of Nephrology, Isfahan University of Medical Sciences, Isfahan, Iran.Department of Nephrology, Isfahan University of Medical Sciences, Isfahan, Iran.Department of Nephrology, Isfahan University of Medical Sciences, Isfahan, Iran.Background: Oxford classification for IgA nephropathy (IgAN) did not include pattern of immunostaining in the analysis. Objective: The aim of this study is to determine the potential correlation between the immunostaining data and morphologic variables of Oxford classification (MEST) and various clinical and demographic data of patients with IgAN. Patients and Methods: The pathologic diagnosis of IgAN requires the demonstration of IgA-dominant mesangial or mesangio-capillary immune deposits through immunofluorescence (IF) microscopy. The immune deposits were semiquantitatively assessed as 0 to 3+ positive bright. These were correlated with various clinical, demographic and histological variables of Oxford classification. Results: A total of 114 biopsies were enrolled to the study (70.2% were male). Mean age of the patients was 37.7 ± 13.6 years. This study showed that, only C3 deposits had a significant correlation with serum creatinine. Other antibodies (IgA, IgM and IgG) had no significant association with serum creatinine. This study also showed that IgA deposition score had significant positive association with endocapillary proliferation (E) and segmental glomerulosclerosis (S) variables of Oxford classification. Moreover, IgM deposition score had positive association with S variable. There was no significant association of IgG deposition score with four morphologic variables of Oxford classification. There was significant association of C3 deposition score with S and E variables too. Conclusions: The significant relationships of IgA and C3 deposits with some of the Oxford variables need more attention. We propose to further investigate this aspect of IgAN disease.https://nephropathol.com/PDF/jnp-2-190.pdfimmunoglobulin a nephropathyimmunoglobulinsimmune depositsimmunofluorescenceimmunostainingdeposition |
| spellingShingle | Hamid Nasri Shahram Sajjadieh Saeed Mardani Ali momeni Alireza Merikhi Yahya Madihi Alaleh Ghiessari Afsoon Emami Naieni Correlation of immunostaining findings with demographic data and variables of Oxford classification in IgA nephropath Journal of Nephropathology immunoglobulin a nephropathy immunoglobulins immune deposits immunofluorescence immunostaining deposition |
| title | Correlation of immunostaining findings with demographic data and variables of Oxford classification in IgA nephropath |
| title_full | Correlation of immunostaining findings with demographic data and variables of Oxford classification in IgA nephropath |
| title_fullStr | Correlation of immunostaining findings with demographic data and variables of Oxford classification in IgA nephropath |
| title_full_unstemmed | Correlation of immunostaining findings with demographic data and variables of Oxford classification in IgA nephropath |
| title_short | Correlation of immunostaining findings with demographic data and variables of Oxford classification in IgA nephropath |
| title_sort | correlation of immunostaining findings with demographic data and variables of oxford classification in iga nephropath |
| topic | immunoglobulin a nephropathy immunoglobulins immune deposits immunofluorescence immunostaining deposition |
| url | https://nephropathol.com/PDF/jnp-2-190.pdf |
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