Effect of Tamarind Gum on the Properties of Phase-Separated Poly(vinyl alcohol) Films

The current study aims to evaluate the effect of tamarind gum (TG) on the optical, mechanical, and drug release potential of poly(vinyl alcohol) (PVA)-based films. This involves preparing PVA-TG composite films with different concentrations of TG through a simple solvent casting method. The addition...

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Main Authors: Madhusmita Rawooth, SK Habibullah, Dilshad Qureshi, Deepti Bharti, Ankit Pal, Biswaranjan Mohanty, Maciej Jarzębski, Wojciech Smułek, Kunal Pal
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Polymers
Subjects:
Online Access:https://www.mdpi.com/2073-4360/14/14/2793
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author Madhusmita Rawooth
SK Habibullah
Dilshad Qureshi
Deepti Bharti
Ankit Pal
Biswaranjan Mohanty
Maciej Jarzębski
Wojciech Smułek
Kunal Pal
author_facet Madhusmita Rawooth
SK Habibullah
Dilshad Qureshi
Deepti Bharti
Ankit Pal
Biswaranjan Mohanty
Maciej Jarzębski
Wojciech Smułek
Kunal Pal
author_sort Madhusmita Rawooth
collection DOAJ
description The current study aims to evaluate the effect of tamarind gum (TG) on the optical, mechanical, and drug release potential of poly(vinyl alcohol) (PVA)-based films. This involves preparing PVA-TG composite films with different concentrations of TG through a simple solvent casting method. The addition of TG has enhanced the phase separation and aggregation of PVA within the films, and it becomes greater with the increase in TG concentration. Brightfield and polarized light micrographs have revealed that aggregation is favored by forming crystalline domains at the PVA-TG interface. The interconnected network of PVA-TG aggregates influenced the swelling and drying properties of the films. Using Peleg’s analysis, the mechanical behavior of films was determined by their stress relaxation profiles. The addition of TG has made no significant changes to the firmness and viscoelastic properties of films. However, long-durational relaxation times indicated that the interconnected network might break down in films with higher TG concentration, suggesting their brittleness. The controlled release of ciprofloxacin in HCl solution (0.5% (<i>w</i>/<i>v</i>)) appears to decrease with the increase in TG concentration. In fact, TG has inversely affected the impedance and altered the ionic conductivity within the films. This seems to have directly influenced the drug release from the films as the mechanism was found to be non-Fickian diffusion (based on Korsmeyer–Peepas and Peppas–Sahlin kinetic models). The antimicrobial study using <i>Escherichia coli</i> was carried out to evaluate the activity of the drug-loaded films. The study proves that TG can modulate the properties of PVA films and has the potential to fine-tune the controlled release of drugs from composite films.
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spelling doaj.art-7f884a9054d94749b6fdc7907012dd002023-12-01T22:36:21ZengMDPI AGPolymers2073-43602022-07-011414279310.3390/polym14142793Effect of Tamarind Gum on the Properties of Phase-Separated Poly(vinyl alcohol) FilmsMadhusmita Rawooth0SK Habibullah1Dilshad Qureshi2Deepti Bharti3Ankit Pal4Biswaranjan Mohanty5Maciej Jarzębski6Wojciech Smułek7Kunal Pal8Department of Biotechnology and Medical Engineering, National Institute of Technology, Rourkela 769008, Odisha, IndiaDepartment of Pharmaceutics, Institute of Pharmacy and Technology, Salipur, Cuttack 754202, Odisha, IndiaDepartment of Biotechnology and Medical Engineering, National Institute of Technology, Rourkela 769008, Odisha, IndiaDepartment of Biotechnology and Medical Engineering, National Institute of Technology, Rourkela 769008, Odisha, IndiaDepartment of Pharmaceutics, Institute of Pharmacy and Technology, Salipur, Cuttack 754202, Odisha, IndiaDepartment of Pharmaceutics, Institute of Pharmacy and Technology, Salipur, Cuttack 754202, Odisha, IndiaDepartment of Physics and Biophysics, Faculty of Food Science and Nutrition, Poznań University of Life Sciences, Wojska Polskiego 38/42, 60-637 Poznan, PolandInstitute of Chemical Technology and Engineering, Poznan University of Technology, Berdychowo 4, 60-695 Poznan, PolandDepartment of Biotechnology and Medical Engineering, National Institute of Technology, Rourkela 769008, Odisha, IndiaThe current study aims to evaluate the effect of tamarind gum (TG) on the optical, mechanical, and drug release potential of poly(vinyl alcohol) (PVA)-based films. This involves preparing PVA-TG composite films with different concentrations of TG through a simple solvent casting method. The addition of TG has enhanced the phase separation and aggregation of PVA within the films, and it becomes greater with the increase in TG concentration. Brightfield and polarized light micrographs have revealed that aggregation is favored by forming crystalline domains at the PVA-TG interface. The interconnected network of PVA-TG aggregates influenced the swelling and drying properties of the films. Using Peleg’s analysis, the mechanical behavior of films was determined by their stress relaxation profiles. The addition of TG has made no significant changes to the firmness and viscoelastic properties of films. However, long-durational relaxation times indicated that the interconnected network might break down in films with higher TG concentration, suggesting their brittleness. The controlled release of ciprofloxacin in HCl solution (0.5% (<i>w</i>/<i>v</i>)) appears to decrease with the increase in TG concentration. In fact, TG has inversely affected the impedance and altered the ionic conductivity within the films. This seems to have directly influenced the drug release from the films as the mechanism was found to be non-Fickian diffusion (based on Korsmeyer–Peepas and Peppas–Sahlin kinetic models). The antimicrobial study using <i>Escherichia coli</i> was carried out to evaluate the activity of the drug-loaded films. The study proves that TG can modulate the properties of PVA films and has the potential to fine-tune the controlled release of drugs from composite films.https://www.mdpi.com/2073-4360/14/14/2793poly(vinyl alcohol)phase separationtamarind gumcomposite filmssolvent castingdrug release
spellingShingle Madhusmita Rawooth
SK Habibullah
Dilshad Qureshi
Deepti Bharti
Ankit Pal
Biswaranjan Mohanty
Maciej Jarzębski
Wojciech Smułek
Kunal Pal
Effect of Tamarind Gum on the Properties of Phase-Separated Poly(vinyl alcohol) Films
Polymers
poly(vinyl alcohol)
phase separation
tamarind gum
composite films
solvent casting
drug release
title Effect of Tamarind Gum on the Properties of Phase-Separated Poly(vinyl alcohol) Films
title_full Effect of Tamarind Gum on the Properties of Phase-Separated Poly(vinyl alcohol) Films
title_fullStr Effect of Tamarind Gum on the Properties of Phase-Separated Poly(vinyl alcohol) Films
title_full_unstemmed Effect of Tamarind Gum on the Properties of Phase-Separated Poly(vinyl alcohol) Films
title_short Effect of Tamarind Gum on the Properties of Phase-Separated Poly(vinyl alcohol) Films
title_sort effect of tamarind gum on the properties of phase separated poly vinyl alcohol films
topic poly(vinyl alcohol)
phase separation
tamarind gum
composite films
solvent casting
drug release
url https://www.mdpi.com/2073-4360/14/14/2793
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