Wet adhesive hydrogels to correct malacic trachea (tracheomalacia) A proof of concept
Summary: Tracheomalacia (TM) is a condition characterized by a weak tracheal cartilage and/or muscle, resulting in excessive collapse of the airway in the newborns. Current treatments including tracheal reconstruction, tracheoplasty, endo- and extra-luminal stents have limitations. To address these...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-07-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223012452 |
| _version_ | 1827895498258776064 |
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| author | Ece Uslu Vijay Kumar Rana Sokratis Anagnostopoulos Peyman Karami Alessandra Bergadano Cecile Courbon Francois Gorostidi Kishore Sandu Nikolaos Stergiopulos Dominique P. Pioletti |
| author_facet | Ece Uslu Vijay Kumar Rana Sokratis Anagnostopoulos Peyman Karami Alessandra Bergadano Cecile Courbon Francois Gorostidi Kishore Sandu Nikolaos Stergiopulos Dominique P. Pioletti |
| author_sort | Ece Uslu |
| collection | DOAJ |
| description | Summary: Tracheomalacia (TM) is a condition characterized by a weak tracheal cartilage and/or muscle, resulting in excessive collapse of the airway in the newborns. Current treatments including tracheal reconstruction, tracheoplasty, endo- and extra-luminal stents have limitations. To address these limitations, this work proposes a new strategy by wrapping an adhesive hydrogel patch around a malacic trachea. Through a numerical model, first it was demonstrated that a hydrogel patch with sufficient mechanical and adhesion strength can preserve the trachea’s physiological shape. Accordingly, a new hydrogel providing robust adhesion on wet tracheal surfaces was synthesized employing the hydroxyethyl acrylamide (HEAam) and polyethylene glycol methacrylate (PEGDMA) as main polymer network and crosslinker, respectively. Ex vivo experiments revealed that the adhesive hydrogel patches can restrain the collapsing of malacic trachea under negative pressure. This study may open the possibility of using an adhesive hydrogel as a new approach in the difficult clinical situation of tracheomalacia. |
| first_indexed | 2024-03-12T22:21:52Z |
| format | Article |
| id | doaj.art-7f89163f679543ad90cf5ad3aca0409b |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-12T22:21:52Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-7f89163f679543ad90cf5ad3aca0409b2023-07-23T04:55:48ZengElsevieriScience2589-00422023-07-01267107168Wet adhesive hydrogels to correct malacic trachea (tracheomalacia) A proof of conceptEce Uslu0Vijay Kumar Rana1Sokratis Anagnostopoulos2Peyman Karami3Alessandra Bergadano4Cecile Courbon5Francois Gorostidi6Kishore Sandu7Nikolaos Stergiopulos8Dominique P. Pioletti9Laboratory of Biomechanical Orthopedics, Institute of Bioengineering, School of Engineering, EPFL, Lausanne, SwitzerlandLaboratory of Biomechanical Orthopedics, Institute of Bioengineering, School of Engineering, EPFL, Lausanne, SwitzerlandLaboratory of Hemodynamics and Cardiovascular Technology, Institute of Bioengineering, School of Engineering, EPFL, Lausanne, SwitzerlandLaboratory of Biomechanical Orthopedics, Institute of Bioengineering, School of Engineering, EPFL, Lausanne, SwitzerlandVeterinary College, Bern, SwitzerlandDepartment of Anesthesiology, University Hospital, CHUV, Lausanne, SwitzerlandDepartment of Otorhinolaryngology, Airway Sector, University Hospital, CHUV, Lausanne, SwitzerlandDepartment of Otorhinolaryngology, Airway Sector, University Hospital, CHUV, Lausanne, SwitzerlandLaboratory of Hemodynamics and Cardiovascular Technology, Institute of Bioengineering, School of Engineering, EPFL, Lausanne, SwitzerlandLaboratory of Biomechanical Orthopedics, Institute of Bioengineering, School of Engineering, EPFL, Lausanne, Switzerland; Corresponding authorSummary: Tracheomalacia (TM) is a condition characterized by a weak tracheal cartilage and/or muscle, resulting in excessive collapse of the airway in the newborns. Current treatments including tracheal reconstruction, tracheoplasty, endo- and extra-luminal stents have limitations. To address these limitations, this work proposes a new strategy by wrapping an adhesive hydrogel patch around a malacic trachea. Through a numerical model, first it was demonstrated that a hydrogel patch with sufficient mechanical and adhesion strength can preserve the trachea’s physiological shape. Accordingly, a new hydrogel providing robust adhesion on wet tracheal surfaces was synthesized employing the hydroxyethyl acrylamide (HEAam) and polyethylene glycol methacrylate (PEGDMA) as main polymer network and crosslinker, respectively. Ex vivo experiments revealed that the adhesive hydrogel patches can restrain the collapsing of malacic trachea under negative pressure. This study may open the possibility of using an adhesive hydrogel as a new approach in the difficult clinical situation of tracheomalacia.http://www.sciencedirect.com/science/article/pii/S2589004223012452Applied sciencesBiomaterials |
| spellingShingle | Ece Uslu Vijay Kumar Rana Sokratis Anagnostopoulos Peyman Karami Alessandra Bergadano Cecile Courbon Francois Gorostidi Kishore Sandu Nikolaos Stergiopulos Dominique P. Pioletti Wet adhesive hydrogels to correct malacic trachea (tracheomalacia) A proof of concept iScience Applied sciences Biomaterials |
| title | Wet adhesive hydrogels to correct malacic trachea (tracheomalacia) A proof of concept |
| title_full | Wet adhesive hydrogels to correct malacic trachea (tracheomalacia) A proof of concept |
| title_fullStr | Wet adhesive hydrogels to correct malacic trachea (tracheomalacia) A proof of concept |
| title_full_unstemmed | Wet adhesive hydrogels to correct malacic trachea (tracheomalacia) A proof of concept |
| title_short | Wet adhesive hydrogels to correct malacic trachea (tracheomalacia) A proof of concept |
| title_sort | wet adhesive hydrogels to correct malacic trachea tracheomalacia a proof of concept |
| topic | Applied sciences Biomaterials |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223012452 |
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