In Vitro Analysis of Biological Activity of Circulating Cell-Free DNA Isolated from Blood Plasma of Schizophrenic Patients and Healthy Controls—Part 2: Adaptive Response

In Vitro Analysis of Biological Activity of Circulating Cell-Free DNA Isolated from Blood Plasma of Schizophrenic Patients and Healthy Controls—Part 2: Adaptive Response

Oxidized in vitro genomic DNA (gDNA) is known to launch an adaptive response in human cell cultures. The cfDNA extracted from the plasma of schizophrenic patients (sz-cfDNA) and healthy controls (hc-cfDNA) contains increased amounts of 8-oxodG, a DNA-oxidation marker. The aim of the research was ans...

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Bibliographic Details
Main Authors: Svetlana V. Kostyuk, Elizaveta S. Ershova, Andrey V. Martynov, Andrey V. Artyushin, Lev N. Porokhovnik, Elena M. Malinovskaya, Elizaveta M. Jestkova, Natalia V. Zakharova, George P. Kostyuk, Vera L. Izhevskaia, Sergey I. Kutsev, Natalia N. Veiko
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Genes
Subjects:
schizophrenia
cell-free DNA
NOX4
NRF2
SOD1
HIF1A
Online Access:https://www.mdpi.com/2073-4425/13/12/2283

Internet

https://www.mdpi.com/2073-4425/13/12/2283

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