Squamous cell carcinoma of the tongue: clinical and morphological analysis of 57 cases and correlation with prognosis
Introduction: Oral squamous cell carcinoma (OSCC), which represents more than 90% of head and neck malignant neoplasms, has a poor prognosis due to its high frequency of lymph node metastasis and local invasion. Previous studies have investigated parameters related to the biological behavior of OSCC...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Patologia Clínica
2014-10-01
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| Series: | Jornal Brasileiro de Patologia e Medicina Laboratorial |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442014000500359&lng=en&tlng=en |
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| author | Marcelo Gadelha Vasconcelos Rodrigo Porpino Mafra Rodrigo Gadelha Vasconcelos Ana Miryam Costa de Medeiros Lélia Maria Guedes Queiroz |
| author_facet | Marcelo Gadelha Vasconcelos Rodrigo Porpino Mafra Rodrigo Gadelha Vasconcelos Ana Miryam Costa de Medeiros Lélia Maria Guedes Queiroz |
| author_sort | Marcelo Gadelha Vasconcelos |
| collection | DOAJ |
| description | Introduction: Oral squamous cell carcinoma (OSCC), which represents more than 90% of head and neck malignant neoplasms, has a poor prognosis due to its high frequency of lymph node metastasis and local invasion. Previous studies have investigated parameters related to the biological behavior of OSCC and its correlation with disease outcome (DO). Objective: To evaluate clinical and morphological data in cases of tongue squamous cell carcinoma (TSCC), correlating these findings with prognosis. Material and methods: Fifty-seven specimens of TSCC were obtained from patients undergoing surgical excision at a referral hospital in Natal, Brazil. Clinical data, such as tumor-node-metastasis (TNM) stage and DO, were collected from medical records. Hematoxylin and eosin-stained sections were analyzed regarding histological grade of malignancy (HGM), based on the system proposed by Bryne (1998) Results: The majority of patients (38.6%) were diagnosed as TNM stage III, and 57.9% developed metastases. Remission of the tumor occurred in 77.2% of the cases. The parameter “metastasis” exhibited a significant association with DO (p = 0) and TNM stage (p = 0.001), thus constituting a good indicator of tumor progression. Correlation of HGM and TNM stage with DO was not evidenced. Nevertheless, statistical analysis showed a significant association between HGM and TNM stage (p = 0.006). Conclusion: TNM clinical staging and HGM, evaluated in association, may be useful to estimate the prognosis of TSCC. |
| first_indexed | 2024-12-10T03:31:22Z |
| format | Article |
| id | doaj.art-7f8aac53a0a045aca4aa8d8f38f7e8e4 |
| institution | Directory Open Access Journal |
| issn | 1678-4774 |
| language | English |
| last_indexed | 2024-12-10T03:31:22Z |
| publishDate | 2014-10-01 |
| publisher | Sociedade Brasileira de Patologia Clínica |
| record_format | Article |
| series | Jornal Brasileiro de Patologia e Medicina Laboratorial |
| spelling | doaj.art-7f8aac53a0a045aca4aa8d8f38f7e8e42022-12-22T02:03:49ZengSociedade Brasileira de Patologia ClínicaJornal Brasileiro de Patologia e Medicina Laboratorial1678-47742014-10-0150535936310.5935/1676-2444.20140040S1676-24442014000500359Squamous cell carcinoma of the tongue: clinical and morphological analysis of 57 cases and correlation with prognosisMarcelo Gadelha VasconcelosRodrigo Porpino MafraRodrigo Gadelha VasconcelosAna Miryam Costa de MedeirosLélia Maria Guedes QueirozIntroduction: Oral squamous cell carcinoma (OSCC), which represents more than 90% of head and neck malignant neoplasms, has a poor prognosis due to its high frequency of lymph node metastasis and local invasion. Previous studies have investigated parameters related to the biological behavior of OSCC and its correlation with disease outcome (DO). Objective: To evaluate clinical and morphological data in cases of tongue squamous cell carcinoma (TSCC), correlating these findings with prognosis. Material and methods: Fifty-seven specimens of TSCC were obtained from patients undergoing surgical excision at a referral hospital in Natal, Brazil. Clinical data, such as tumor-node-metastasis (TNM) stage and DO, were collected from medical records. Hematoxylin and eosin-stained sections were analyzed regarding histological grade of malignancy (HGM), based on the system proposed by Bryne (1998) Results: The majority of patients (38.6%) were diagnosed as TNM stage III, and 57.9% developed metastases. Remission of the tumor occurred in 77.2% of the cases. The parameter “metastasis” exhibited a significant association with DO (p = 0) and TNM stage (p = 0.001), thus constituting a good indicator of tumor progression. Correlation of HGM and TNM stage with DO was not evidenced. Nevertheless, statistical analysis showed a significant association between HGM and TNM stage (p = 0.006). Conclusion: TNM clinical staging and HGM, evaluated in association, may be useful to estimate the prognosis of TSCC.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442014000500359&lng=en&tlng=encarcinoma de células escamosaspatologia bucalprognóstico |
| spellingShingle | Marcelo Gadelha Vasconcelos Rodrigo Porpino Mafra Rodrigo Gadelha Vasconcelos Ana Miryam Costa de Medeiros Lélia Maria Guedes Queiroz Squamous cell carcinoma of the tongue: clinical and morphological analysis of 57 cases and correlation with prognosis Jornal Brasileiro de Patologia e Medicina Laboratorial carcinoma de células escamosas patologia bucal prognóstico |
| title | Squamous cell carcinoma of the tongue: clinical and morphological analysis of 57 cases and correlation with prognosis |
| title_full | Squamous cell carcinoma of the tongue: clinical and morphological analysis of 57 cases and correlation with prognosis |
| title_fullStr | Squamous cell carcinoma of the tongue: clinical and morphological analysis of 57 cases and correlation with prognosis |
| title_full_unstemmed | Squamous cell carcinoma of the tongue: clinical and morphological analysis of 57 cases and correlation with prognosis |
| title_short | Squamous cell carcinoma of the tongue: clinical and morphological analysis of 57 cases and correlation with prognosis |
| title_sort | squamous cell carcinoma of the tongue clinical and morphological analysis of 57 cases and correlation with prognosis |
| topic | carcinoma de células escamosas patologia bucal prognóstico |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442014000500359&lng=en&tlng=en |
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