High fructose intake fails to induce symptomatic adaptation but may induce intestinal carriers
Fructose has several interactions in man, including intolerance and promotion of some diseases. However, fructose in fruits and in prebiotics may be associated with benefits. Adaptation to regular fructose ingestion as defined for lactose could support a beneficial rather than a deleterious effect....
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2010-01-01
|
| Series: | Gastroenterology Insights |
| Subjects: | |
| Online Access: | http://www.pagepress.org/journals/index.php/gi/article/view/1428 |
| _version_ | 1811253637065736192 |
|---|---|
| author | Debra Heilpern Rateb Nabil Abbas Stephanie Gladman Maryse Menard Byong H Lee Andrew Szilagyi |
| author_facet | Debra Heilpern Rateb Nabil Abbas Stephanie Gladman Maryse Menard Byong H Lee Andrew Szilagyi |
| author_sort | Debra Heilpern |
| collection | DOAJ |
| description | Fructose has several interactions in man, including intolerance and promotion of some diseases. However, fructose in fruits and in prebiotics may be associated with benefits. Adaptation to regular fructose ingestion as defined for lactose could support a beneficial rather than a deleterious effect. This study was undertaken to evaluate symptomatic response and potential underlying mechanisms of fecal bacterial change and breath hydrogen response to short term regular fructose supplementation. Forty-five participants were recruited for a 3 day recall diet questionnaire and a 50 g fructose challenge. Breath hydrogen was measured for 4.5 hrs and symptoms were recorded. Thirty-eight subjects provided stool samples for analysis by selective culture of 4 groups of bacteria, including bifidobacteria and lactobacilli. Intolerant subjects returned a second time 15 days later. Ten of these served as controls and 16 received 30 g fructose twice a day. Ten of the latter returned 27 days later, after stopping fructose for a third challenge test. Student’s paired, unpaired t-tests and Pearson correlations were used. Significance was accepted at P<0.05. After fructose rechallenge there were no significant reductions in symptoms scores in volunteers in either the fructose supplemented or non supplemented groups. However, total breath hydrogen was reduced between test 1 and test 2 (P=0.03) or test 3 (P=0.04) in the group given fructose then discontinued, compared with controls. There were no statistically significant changes in bacterial numbers between test 2 and 1. This study shows that regular consumption of high dose fructose does not follow the lactose model of adaptation. Observed changes in hydrogen breath tests raise the possibility that intestinal carriers of fructose may be induced potentially aggravating medical problems attributed to fructose. |
| first_indexed | 2024-04-12T16:53:57Z |
| format | Article |
| id | doaj.art-7f8b5c26cea54064afc072256802d0af |
| institution | Directory Open Access Journal |
| issn | 2036-7414 2036-7422 |
| language | English |
| last_indexed | 2024-04-12T16:53:57Z |
| publishDate | 2010-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gastroenterology Insights |
| spelling | doaj.art-7f8b5c26cea54064afc072256802d0af2022-12-22T03:24:18ZengMDPI AGGastroenterology Insights2036-74142036-74222010-01-0121e3e310.4081/gi.2010.e31027High fructose intake fails to induce symptomatic adaptation but may induce intestinal carriersDebra Heilpern0Rateb Nabil Abbas1Stephanie Gladman2Maryse Menard3Byong H Lee4Andrew Szilagyi5Jewish General Hospital McGill universityDepartment of Microbial Biotechnology, Genetic Engineering and Biotechnology Research Institute (GEBRI), Minufiya University, Egypt.Jewish General Hospital, McGill universityJewish General Hospital, McGill UniversityMicrobiology, Mcgill UniversityJewish General Hospital, McGill UniversityFructose has several interactions in man, including intolerance and promotion of some diseases. However, fructose in fruits and in prebiotics may be associated with benefits. Adaptation to regular fructose ingestion as defined for lactose could support a beneficial rather than a deleterious effect. This study was undertaken to evaluate symptomatic response and potential underlying mechanisms of fecal bacterial change and breath hydrogen response to short term regular fructose supplementation. Forty-five participants were recruited for a 3 day recall diet questionnaire and a 50 g fructose challenge. Breath hydrogen was measured for 4.5 hrs and symptoms were recorded. Thirty-eight subjects provided stool samples for analysis by selective culture of 4 groups of bacteria, including bifidobacteria and lactobacilli. Intolerant subjects returned a second time 15 days later. Ten of these served as controls and 16 received 30 g fructose twice a day. Ten of the latter returned 27 days later, after stopping fructose for a third challenge test. Student’s paired, unpaired t-tests and Pearson correlations were used. Significance was accepted at P<0.05. After fructose rechallenge there were no significant reductions in symptoms scores in volunteers in either the fructose supplemented or non supplemented groups. However, total breath hydrogen was reduced between test 1 and test 2 (P=0.03) or test 3 (P=0.04) in the group given fructose then discontinued, compared with controls. There were no statistically significant changes in bacterial numbers between test 2 and 1. This study shows that regular consumption of high dose fructose does not follow the lactose model of adaptation. Observed changes in hydrogen breath tests raise the possibility that intestinal carriers of fructose may be induced potentially aggravating medical problems attributed to fructose.http://www.pagepress.org/journals/index.php/gi/article/view/1428fructose, adaptation, symptomatic, physiologic, bacterial. |
| spellingShingle | Debra Heilpern Rateb Nabil Abbas Stephanie Gladman Maryse Menard Byong H Lee Andrew Szilagyi High fructose intake fails to induce symptomatic adaptation but may induce intestinal carriers Gastroenterology Insights fructose, adaptation, symptomatic, physiologic, bacterial. |
| title | High fructose intake fails to induce symptomatic adaptation but may induce intestinal carriers |
| title_full | High fructose intake fails to induce symptomatic adaptation but may induce intestinal carriers |
| title_fullStr | High fructose intake fails to induce symptomatic adaptation but may induce intestinal carriers |
| title_full_unstemmed | High fructose intake fails to induce symptomatic adaptation but may induce intestinal carriers |
| title_short | High fructose intake fails to induce symptomatic adaptation but may induce intestinal carriers |
| title_sort | high fructose intake fails to induce symptomatic adaptation but may induce intestinal carriers |
| topic | fructose, adaptation, symptomatic, physiologic, bacterial. |
| url | http://www.pagepress.org/journals/index.php/gi/article/view/1428 |
| work_keys_str_mv | AT debraheilpern highfructoseintakefailstoinducesymptomaticadaptationbutmayinduceintestinalcarriers AT ratebnabilabbas highfructoseintakefailstoinducesymptomaticadaptationbutmayinduceintestinalcarriers AT stephaniegladman highfructoseintakefailstoinducesymptomaticadaptationbutmayinduceintestinalcarriers AT marysemenard highfructoseintakefailstoinducesymptomaticadaptationbutmayinduceintestinalcarriers AT byonghlee highfructoseintakefailstoinducesymptomaticadaptationbutmayinduceintestinalcarriers AT andrewszilagyi highfructoseintakefailstoinducesymptomaticadaptationbutmayinduceintestinalcarriers |