Shifting the optimal stiffness for cell migration
Cell migration is sensitive to environmental stiffness, but how cells sense optimal stiffness is not known. Here the authors develop a model that predicts that the optimum can be shifted by altering the number of active molecular motors and clutches, and verify their model in two cell types.
Bibliographic Details
| Main Authors: |
Benjamin L. Bangasser,
Ghaidan A. Shamsan,
Clarence E. Chan,
Kwaku N. Opoku,
Erkan Tüzel,
Benjamin W. Schlichtmann,
Jesse A. Kasim,
Benjamin J. Fuller,
Brannon R. McCullough,
Steven S. Rosenfeld,
David J. Odde |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2017-05-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms15313
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