Application of “omics” sciences to the prediction of bone metastases from breast cancer: State of the art
Breast cancer (BC) is the most frequent malignancy and the first cause of cancer-related death in women.The majority of patients with advanced BC develop skeletal metastases which may ultimately lead to serious complications, termed skeletal-related events, that often dramatically impact on quality...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-02-01
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| Series: | Journal of Bone Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212137420300920 |
| _version_ | 1818580426537566208 |
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| author | Marica Gentile Antonella Centonza Domenica Lovero Raffaele Palmirotta Camillo Porta Franco Silvestris Stella D'Oronzo |
| author_facet | Marica Gentile Antonella Centonza Domenica Lovero Raffaele Palmirotta Camillo Porta Franco Silvestris Stella D'Oronzo |
| author_sort | Marica Gentile |
| collection | DOAJ |
| description | Breast cancer (BC) is the most frequent malignancy and the first cause of cancer-related death in women.The majority of patients with advanced BC develop skeletal metastases which may ultimately lead to serious complications, termed skeletal-related events, that often dramatically impact on quality of life and survival.Therefore, the identification of biomarkers able to stratify BC patient risk to develop bone metastases (BM) is fundamental to define personalized diagnostic and therapeutic strategies, possibly at the earliest stages of the disease.In this regard, the advent of “omics” sciences boosted the investigation of several putative biomarkers of BC osteotropism, including deregulated genes, proteins and microRNAs.The present review revisits the current knowledge on BM development in BC and the most recent studies exploring potential BM-predicting biomarkers, based on the application of omics sciences to the study of primary breast malignancies. |
| first_indexed | 2024-12-16T07:17:25Z |
| format | Article |
| id | doaj.art-7f8c0dea61a24a2b80ae5048f30d76fd |
| institution | Directory Open Access Journal |
| issn | 2212-1374 |
| language | English |
| last_indexed | 2024-12-16T07:17:25Z |
| publishDate | 2021-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Bone Oncology |
| spelling | doaj.art-7f8c0dea61a24a2b80ae5048f30d76fd2022-12-21T22:39:45ZengElsevierJournal of Bone Oncology2212-13742021-02-0126100337Application of “omics” sciences to the prediction of bone metastases from breast cancer: State of the artMarica Gentile0Antonella Centonza1Domenica Lovero2Raffaele Palmirotta3Camillo Porta4Franco Silvestris5Stella D'Oronzo6Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124 Bari, Italy“Casa Sollievo della Sofferenza” Onco-hematologic Department, Medical Oncology Unit, Viale Cappuccini 1, 71013 San Giovanni Rotondo, ItalyDepartment of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124 Bari, ItalyDepartment of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124 Bari, ItalyDepartment of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124 Bari, ItalyDepartment of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124 Bari, ItalyDepartment of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124 Bari, Italy; Corresponding author.Breast cancer (BC) is the most frequent malignancy and the first cause of cancer-related death in women.The majority of patients with advanced BC develop skeletal metastases which may ultimately lead to serious complications, termed skeletal-related events, that often dramatically impact on quality of life and survival.Therefore, the identification of biomarkers able to stratify BC patient risk to develop bone metastases (BM) is fundamental to define personalized diagnostic and therapeutic strategies, possibly at the earliest stages of the disease.In this regard, the advent of “omics” sciences boosted the investigation of several putative biomarkers of BC osteotropism, including deregulated genes, proteins and microRNAs.The present review revisits the current knowledge on BM development in BC and the most recent studies exploring potential BM-predicting biomarkers, based on the application of omics sciences to the study of primary breast malignancies.http://www.sciencedirect.com/science/article/pii/S2212137420300920Breast cancerOsteotropismBone metastasesBiomarkersOmics sciences |
| spellingShingle | Marica Gentile Antonella Centonza Domenica Lovero Raffaele Palmirotta Camillo Porta Franco Silvestris Stella D'Oronzo Application of “omics” sciences to the prediction of bone metastases from breast cancer: State of the art Journal of Bone Oncology Breast cancer Osteotropism Bone metastases Biomarkers Omics sciences |
| title | Application of “omics” sciences to the prediction of bone metastases from breast cancer: State of the art |
| title_full | Application of “omics” sciences to the prediction of bone metastases from breast cancer: State of the art |
| title_fullStr | Application of “omics” sciences to the prediction of bone metastases from breast cancer: State of the art |
| title_full_unstemmed | Application of “omics” sciences to the prediction of bone metastases from breast cancer: State of the art |
| title_short | Application of “omics” sciences to the prediction of bone metastases from breast cancer: State of the art |
| title_sort | application of omics sciences to the prediction of bone metastases from breast cancer state of the art |
| topic | Breast cancer Osteotropism Bone metastases Biomarkers Omics sciences |
| url | http://www.sciencedirect.com/science/article/pii/S2212137420300920 |
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